1DVK


Conserved Protein Domain Family
Prp18

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pfam02840: Prp18 
Prp18 domain
The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles.
Statistics
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PSSM-Id: 397123
Aligned: 86 rows
Threshold Bit Score: 148.019
Threshold Setting Gi: 7546208
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DVK_A        38 YIHEILSRWKASLEAY-----------HPE----------------------LFLDTKKALFPLLLQLRRNQLAPDLLIS 84 
CCG85076     175 LLKFYIKQWDHDVRSSspdgge-------------------------ssqvaMQKQAKEHLARLLLRLKTGNLPIDILTN 229 Taphrina deform...
Q6C1J2       147 FLARLLSEWEGTLDKGaaaqasgaaeeVSEaanay-------------krhtIFEETQTSLSSLMVLLRHNGLQDEVLAM 213 Yarrowia lipoly...
EDK43006     178 YLKNLISEWEKEESNS-----------GDhd--------------------sLLLETKKDIVKLLYKLRANKLSEEMLIS 226 Lodderomyces el...
CCE43715     164 YLKEIIREWDSQHNKS-----------DEda--------------------sLLKETKKGIVNLLYKLRSGKIPTEALVS 212 Candida parapsi...
XP_007375085 138 YIKEMIKSWQDCNEAH-----------PSDqq------------------taLLFETKRDIVPLLYGLRTGELSEDILTS 188 Spathaspora pas...
XP_001382798 151 CIKDMIRNWEDSINYSeyqta---------------------------vqkkLLHETKRDIVKLLYKLRSHKLNDDMLTS 203 Scheffersomyces...
XP_004203243 147 ILKDIVREWESNVQTD-----------TPEpq-------------------rVLYEAKRDLVELLYRLRSNSLKPNMLTS 196 Pichia farinosa...
EGV59989     156 YIKSLVHQWEKATEAL-----------PPDspq-----------------heLLLDTKKNLVPLLYKLRSDGLTDDMVVS 207 Yamadazyma tenu...
Q6BYT3       146 YVKYMVKEWENDVQLK-----------TEGfssirddeeregeeesvarqssMLLDTKKDLVRLLYKLRTQKLTDSMLTS 214 Debaryomyces ha...
1DVK_A        85 LATVLYHLQQpKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIqG----G-RN--AANIMIDERTRLWITSIKR 157
CCG85076     230 LASVVSSLQQ-ADFTGANRAYLQMSIGKATWPVGVTSVGIHERAQRERQ-H----KkLD--SAHILADETTRQWLQSLKR 301 Taphrina deform...
Q6C1J2       214 LSKVMYHVQH-EEHHQAYDVYLKLCIGNACWPVGVASIGIHARASQNKT-IasarNsKQ--VAHIVNDD-TRQWLVCIKR 288 Yarrowia lipoly...
EDK43006     227 LATIVYHIQA-SQFNKANESYMKLSIGNICWPIGVANVGIHARSASTRI-T----GgKG--VSNIMINESTRKWILSVKR 298 Lodderomyces el...
CCE43715     213 LSTIIYYLQS-NQFNKANESYMKLSIGNVCWPIGVVNVGIHARSSSSRI-T----GsKN--VSNIMMNELTRKWIISVKR 284 Candida parapsi...
XP_007375085 189 LTTIIYYIQQ-KDYRRANESYMKLSIGNVAWPIGVLNVGIHARSAAERI-T----GqKK--QANIMIDDKTRRWITSIKR 260 Spathaspora pas...
XP_001382798 204 LTTIVFYLQS-HDFRRANESYMKLSIGNVAWPIGVQNVGIHARSASSKI-A----GaTK--AANIMVDDKTRRWITAIKR 275 Scheffersomyces...
XP_004203243 197 LATVLYHVQR-AQFKEANESYLKLSIGNVAWPIGVKSVGIHERSASSKI-T----GeSKdkSANIMLDDKTRRWITAVKR 270 Pichia farinosa...
EGV59989     208 LSTICYYLQH-RQFRPANESYMKLSIGNVAWPIGVLHVGIHARSASSRI-T----GeKS--AANIMIDDKTRRWITAVKR 279 Yamadazyma tenu...
Q6BYT3       215 LCTIMYYLQV-RDYRRANESYMKLSIGNVAWPIGVKGVGIHERSAALKI-T----GeNKqnSANIMLDDKTRRWITAIKR 288 Debaryomyces ha...
1DVK_A       158 LITFEEWY 165
CCG85076     302 LITYREKR 309 Taphrina deformans PYCC 5710
Q6C1J2       289 LLTFAEGY 296 Yarrowia lipolytica
EDK43006     299 LIGFKERM 306 Lodderomyces elongisporus NRRL YB-4239
CCE43715     285 LINFKERR 292 Candida parapsilosis
XP_007375085 261 LITAKERI 268 Spathaspora passalidarum NRRL Y-27907
XP_001382798 276 IITATERI 283 Scheffersomyces stipitis CBS 6054
XP_004203243 271 LITYKEKS 278 Pichia farinosa CBS 7064
EGV59989     280 LITFSETY 287 Yamadazyma tenuis ATCC 10573
Q6BYT3       289 LISFAERK 296 Debaryomyces hansenii
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