3WYG


Conserved Protein Domain Family
PKI

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pfam02827: PKI 
cAMP-dependent protein kinase inhibitor
Members of this family are extremely potent competitive inhibitors of camp-dependent protein kinase activity. These proteins interact with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Statistics
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PSSM-Id: 397113
Aligned: 27 rows
Threshold Bit Score: 68.0886
Threshold Setting Gi: 395534866
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WYG_D         2 TDVETTYADFIASGRTGRRNAIHDILVSSASGNL-NELALKLAGLDI---NKTEGEEDAQRSSTEQSGEAQGE 70 
O70139         2 MEVESSYSDFISCDRTGRRNAVPDIQGDSEAVSV-RKLAGDMGELAL---EGAEGQAEGSTPDKEASSQPESS 70  house mouse
EFB14134       2 MGVKTSYSISISGDRTGCQNTVLDTQADSETVSM-RKLAKDMDELAL---EGAERQAEAGTPDREASKQSESN 70  giant panda
XP_001515972  27 MEVESSYSDFISCDRTGRRNAVPDIQSGAEAASV-RKLAGDLGELAL---ETAEGQAEASAADKEAGASPEGS 95  platypus
XP_003757771   1 MEVESSYTDFISCDRTGRRNAVPDIQDDSAAVSV-RKLTGNMGELAL---EGAEGQEERSTSDKEAGTTPEGN 69  Tasmanian devil
XP_015220181   2 MEVESAYSDFISCDRTGRRNAVPDIGGEGAKVGT-GELTKDMAQMDL---KAPEEEGTIASQSSQGEVAGSQE 70  spotted gar
XP_005477977   2 MDVETSYSDFINCDRTGRRNAVPDISGEGSVVTStSELTKDMAEMDL---KAAAGGDPGSSPAPEAEGSNSQA 71  Nile tilapia
XP_015210495   2 TDVEATYADFIASGRTGRRNALHDILGAQGDLEG-GDLSLKLSELDLgktGEGDGGEKSQASSTERPPSAQEE 73  spotted gar
Q5BKM1         2 TDVESTYADFIASGRTGRRNALHDILVSSSSGNT-SELALKLSELDI---SKSEGDENEKENPSDKTPEEKNQ 70  tropical clawed frog
XP_007486990  16 TDVETTYADFIASGRTGRRNAIHDIIVTSSTTNT-TDVSVKLSDLDI---NKPDGEGDGQKSPPEQSGDNQGG 84  gray short-tailed opossum
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