2EKI,4A9A


Conserved Protein Domain Family
TGS

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pfam02824: TGS 
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TGS domain
The TGS domain is named after ThrRS, GTPase, and SpoT. Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role.
Statistics
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PSSM-Id: 397110
Aligned: 54 rows
Threshold Bit Score: 56.7809
Threshold Setting Gi: 141353
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EKI_A  12 VRIYTkPKGQLPDytspvvLPYSRTtVEDFCMKIHKNLIKEFKYALVWGlsvkhnpQKVGKDHTLEDEDVIQIVK 86  human
P87144  49 IDITL-PDGKVIK------GTSWETtPISIAASISKGLADRVTVAIVNG-------EPWDLTRPLEASCTLKLCD 109 Schizosaccharomyces pombe ...
O04630  75 IKVTL-PDGNVKE------GKKWETtPMDIAAQISKGLANSALISAVDD-------VLWDMNRPLEGDCKLELFK 135 thale cress
P26639  83 IKVTL-PDGKQVD------AESWKTtPYQIACGISQGLADNTVIAKVNN-------VVWDLDRPLEEDCTLELLK 143 human
P52709  82 IQITL-PDGKIHE------GKTWRTtPFEIAERISKGLAEAAVIAKVNG-------AVWDLDRPFEGNAKLELLK 142 Caenorhabditis elegans
Q9WZJ9   3 IKVKL-PDGKEKE------YDRGIT-PAEIAKELG---IKKAIGAVVNG-------ELWDLKRPIENDCELRLVT 59  Thermotoga maritima MSB8
P18256   5 VHIQL-PDGQIQE------YPKGIT-IKEAAGSISSSLQKKAAAGQVNG-------KLVDLSFKLEEDAELSIVT 64  Bacillus subtilis subsp. s...
P18255   5 VKITF-PDGAVKE------FAKGTT-TEDIAASISPGLKKKSLAGKLNG-------KEIDLRTPINEDGTVEIIT 64  Bacillus subtilis subsp. s...
P43014   2 PIITL-PDGSQRQ------FDRPVS-VLEVAQDIGAGLAKATIAGRVNG-------ERRDACYVIEQDATLEIIT 61  Haemophilus influenzae Rd ...
P0A8M3   2 pvITL-PDGSQRH------YDHAVS-PMDVALDIGPGLAKACIAGRVNG-------ELVDACDLIENDAQLSIIT 61  Escherichia coli K-12
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