5E4H


Conserved Protein Domain Family
Alpha_kinase

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pfam02816: Alpha_kinase 
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Alpha-kinase family
This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.
Statistics
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PSSM-Id: 397104
Aligned: 168 rows
Threshold Bit Score: 88.1668
Threshold Setting Gi: 328862519
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5E4H_D                 53 AEGALREAYHtvslgvGtdenyplgxttklfppiemispisknneamTQLKNGTKFVLKLYKKEAEQQa--------SRE 124  Dicty...
PNI74886                1 --GLRRAVKV------Qctws-----------------------ehdILKSGHLYIIKSFLPEVVNTWssiykedtvLHL 49   chimp...
XP_001744882          709 RQGAYHSAYP------A------------------------------YLSGTEDSFVLKWPCYATMQ----------TQE 742  Monos...
EGG11620              197 AFWAARSICI------D------------------------------EHEELHGKYIIKHSLLWDDRD---------SRA 231  Melam...
EGG01608              123 afwvAKNIYI------D------------------------------AHDELHGKYIIKSSLLWDDCD---------SRA 157  Melam...
XP_003324792          316 GSGGMRTAYA------Aevkt-----------------------evaDGIEHINHWVAKIRLDEVEP----------SID 356  Pucci...
XP_003338353          191 GQGSMRITYK------Avvki-----------------------vegNGEVTLVDYVAKKRFHDLTP----------SVE 231  Pucci...
WGS:AAWC:PGTG_01007.3  38 GTGGMRITYA------Aqvks-----------------------ideDEVEVISDYVAKVMKDPEHQ----------DLT 78   Pucci...
EGG04200              192 GKGTRRYSYK------Gtl----------------------------lIDGKSQSVVVKEILNEEHQ----------DEE 227  Melam...
BAB71558               75 GKESEQWSVE------K------------------------------HTTKSPTDTFGTI-------------------- 98   human
5E4H_D                125 LYFEXVKMQMVCRDWGNKFN-----------QKKPPKK--------IE---FLMSWVV-ElI-----DRspSsngqpiLC 176  Dicty...
PNI74886               50 CLREIQQQRAAQKLTFAFNQmk--------pKSIPYSP--------RF---LEVFLLYc--------HSagQw-----FA 97   chimp...
XP_001744882          743 ASEIGLSKVAHASRIAQAFNaa--------lGRSSENA--------VS---FAQPRAVq--LtarpaANgrVp-----WA 796  Monos...
EGG11620              232 HCFERAQSNRFALMMLGAFQqsilihkrrkeRNQGCANd-------MHrqmYSESLSL-KtA-----RSlfDqa---rWF 295  Melam...
EGG01608              158 HCFERSQSNRYATTLLEAFRqs-------ilIHKRRKErkrgasnnLHrqiYSDCCAL---KtarsvYDgaPr-----WL 222  Melam...
XP_003324792          357 QHATDALMYEGFSHLLAQFKleish--ceylRSKLKNKgssiqasdFN---LLVRHAV-VaN-----GPinSpt---nVY 422  Pucci...
XP_003338353          232 KHATDALMYEASALLLDSFKkvlsrcralhkAYRKKLQl-------LE---VIRHAVVvTgD-----VDipSe-----VY 291  Pucci...
WGS:AAWC:PGTG_01007.3  79 RHATDARMYEACALLLAEYRsvvhdcrilpmSTKAKAKq-------MQ---IIRHSVVfTgD-----LFfpTd-----VY 138  Pucci...
EGG04200              228 AYLTELAVYHLTSCLLERFKiam------ffSTHVTND--------QK---LLLNTLR---P-----SGthAq-----YI 277  Melam...
BAB71558               99 -NFQDGEHTHHAKYIRTSYD----------------TK--------LD---HLLHLML---K----------------EW 131  human
5E4H_D                177 --SIEPLL-V-GE------FKKNNSN--YGAV---------------------LTNRSTPQAFSHFTYELSNKQM----I 219  Dicty...
PNI74886               98 --VEECMT-G-EF------RKYNNNN--GDEIip-----------------tnTLEEIMLAFSHWTYEYTRGELL----V 144  chimp...
XP_001744882          797 --LLEPELeDlEAtgvmdyFCIFNDS--AGGVvseedmqdevgdhgedwreefRECNDLAQALSCYSYHASQRQE----L 868  Monos...
EGG11620              296 --ICEGKT-DpKS------THRYIWE--YDFHalp---------------tekQTWTDHLYAWFHYTYEVTGGQTlfagL 349  Melam...
EGG01608              223 --ICEGLY-DpNT------THRYIWE--YDFNslp---------------rdkQTWTDHINAWVHYTYEVSGNQTlivgL 276  Melam...
XP_003324792          423 --FLEAFL-D-GP------YVKYSSN--DNFAvpnnq------------pgmdLDLFKLMNAFTHWTYNNSMGKH----L 474  Pucci...
XP_003338353          292 --FIEAAL-K-GK------YVKYSSN--TDFNvdeee------------egidPIICRLMNTFTHWSYHESAGQQ----L 343  Pucci...
WGS:AAWC:PGTG_01007.3 139 --FFEKRL-T-GP------YVKYSSN--TDFNispnq------------pgmdPKILQLMNTFTHWTYNTSEGKN----L 190  Pucci...
EGG04200              278 tyLIEEVL-----------YHPLEVI--CTTRdfsp-------------sqpeSISSDCLSAFVHFTYDYFRGQA----L 327  Melam...
BAB71558              132 --KME--------------LPKLVISvhGGIQn--------------------FTMPS------KFKEIFSQGLV----K 165  human
5E4H_D                220 VVDIQGVDDLYTDPQIHT--PDGkg-----fGLGNLGKAGINKFITTHKCNAVC 266  Dictyostelium discoideum
PNI74886              145 LDLQGVGENLTDPSVIKAeeKRScdm--vfgPANLGEDAIKNFRAKHHCNSCCR 196  chimpanzee
XP_001744882          869 MINIQGVRHRYTNPDFHF--ASAvhd--pyfSPHNNGPEGIAAFQRSHVHNDFC 918  Monosiga brevicollis MX1
EGG11620              350 DCDEHG---QLSNLVLFT--KGKpphydesaGMKARIDRAFLHFREQHVCNKIC 398  Melampsora larici-populina 98AG31
EGG01608              277 DCDEHG---VLTNLVLFT--KGKplhydesaVMKGRIEHTFMHFRKQHECNKIC 325  Melampsora larici-populina 98AG31
XP_003324792          475 VSDLQGVGSTLTDPQIID--MDPhs-----wSDGNTSSDGIAQFLKDHICHPGN 521  Puccinia graminis f. sp. tritic...
XP_003338353          344 ICDLQGVGPIITDPQIID--VDQtr-----wADGNNSNYGIRKFVEDHECNELC 390  Puccinia graminis f. sp. tritic...
WGS:AAWC:PGTG_01007.3 191 VGDLQGVGPLITDPQILD--MNEnl-----wTLGNNSADGIQAFIKDHICNEVC 237  Puccinia graminis f. sp. tritic...
EGG04200              328 VSNIKFKDGLLTGMRMID--LRHk------wSWDNPRQDGIDAFISSHICGTAC 373  Melampsora larici-populina 98AG31
BAB71558              166 AAETTGa---------------------------wIITEGINTGVSKHVGDALK 192  human
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