6ICZ


Conserved Protein Domain Family
Mago_nashi

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pfam02792: Mago_nashi 
Mago nashi protein
This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene. The human homolog has been shown to interact with an RNA binding protein. An RNAi knockout of the C. elegans homolog causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination. Mago nashi has been found to be part of the exon-exon junction complex that binds 20 nucleotides upstream of exon-exon junctions.
Statistics
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PSSM-Id: 397085
Aligned: 38 rows
Threshold Bit Score: 203.206
Threshold Setting Gi: 67471385
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6ICZ_VV        9 LRYYVGHKGKFGHEFLEFEFrPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITK---EDDALWPPPDR- 84 
EGC39015      49 LRYYVGHKGKYGHEFLEFEFrSGNKLRYANNSHYKSENLIRKEVCVSDSVLAEIKKIILDSGIMQ---EDDKDWPEPDI- 124 Dictyostelium p...
EFC44599       1 ---YVGHKGKYGHEFLEITFhPDGLLEYKNNTDYKGEGEILKTVNLNNIVLEQLKTIILESRIME---ESDRKWPLPDN- 73  Naegleria gruberi
XP_004347475  25 LRYYTGHKGKFGHEFLEFEFsSDGLLRYANNTHYRGETIIRKQVYVSRAVLQELKRILADSEITR---EDGNMWPKPERs 101 Capsaspora owcz...
XP_651644     15 LRYYNGNHNQYGKEYIKFEIfDNGELKYCNQSRYRNETEIIKKLHLTRVVMKEIQDIISQSHILI---QTDAHWPNKIN- 90  Entamoeba histo...
Q586G7         8 VRYFAGHTGRYGNEFLEFDIrDDGTLKYGNNSRYRNENIIKKQARISPAVLEEIKRLIILSGILE---RDDECWPQPDR- 83  Trypanosoma brucei
CCA69878      10 FRYYTGHSGKHGHEFLEFEY-SHGRLRYANNSNYRNDSLIRKEMFIGPLVVKELKRIVETSEIVK---EDDSNWPKPNI- 84  Serendipita ind...
XP_003381674   8 LRYYGGSRGKFGHEFIEFVIkPNGHFMYINNSHYKNDTVIKRKGYLSATAIQAFKDMIKDSNILT---EDDSKWPEPDY- 83  Trichinella spi...
ELU41311      14 VSYYTGHSGRHGHEFLEFEY-SNGRLRYANNSNYRNDSSFRVSVWVGPLLVKELKRIVESSEIIKyviKNDANWPKKNI- 91  Rhizoctonia sol...
XP_012049242  13 LRYYTGHQGAHGHEFLEFEY-SYGRIRYANNSNYRNDSLIRKEMFVSPAVVDELKRIVRESEITK---EDDVAWPRKNV- 87  Cryptococcus ne...
6ICZ_VV       85 VGRQELEIVIGDEHISFT------------------TSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLI 139
EGC39015     125 VGKQELEIVLKNEHISFT------------------TTKIGSLMDVEKSKDPEGLKVMFYLIQDLKCLVFSLI 179 Dictyostelium purpureum
EFC44599      74 IGKSELEIVLDKEHISFA------------------TTKIQTLSEVTKSHDPEGLKNFYYLTADLKDFALNLI 128 Naegleria gruberi
XP_004347475 102 GGKQELDIEMDGVRKSFN------------------VSVIGKLSDVDNSNDAEGLKIFFYLVQDLKAFVYSLI 156 Capsaspora owczarzaki ...
XP_651644     91 GSRQELEIEMNDIHIFFV------------------TSKFGTLNEIRQSEDPQGLLIFYNFINDLICLLTTLT 145 Entamoeba histolytica ...
Q586G7        84 NGRQELEIHLGDTHISFV------------------TNKITSLSEVESPDKPKGLDTFYYFVRDIKALVLALV 138 Trypanosoma brucei
CCA69878      85 VGKQELEIRIGNDHISFH------------------TAKIGSLMDVSESEDPEGLRVFYYLVQDVKCLVFSLI 139 Serendipita indica DSM...
XP_003381674  84 KGKQELEICMDGQHVSFT------------------CCKLFSVSDCENSRDPDGLRALYYLAQDLKCLVFAIM 138 Trichinella spiralis
ELU41311      92 VGKQELEIKLGNDHISFEvnaprpnicaaladlciqTAKIGSLVDVQESEDPEGLRVFYYLVQDLRHLAWRLA 164 Rhizoctonia solani AG-...
XP_012049242  88 VGKQELEVRIDKEHISFE------------------TAKIGALAEVNDSSDPDGLRVFYYLIQDLKCFIFALI 142 Cryptococcus neoforman...
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