1X1O,3TQV,3L0G,1O4U


Conserved Protein Domain Family
QRPTase_N

?
pfam02749: QRPTase_N 
Click on image for an interactive view with Cn3D
Quinolinate phosphoribosyl transferase, N-terminal domain
Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyzes the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The N-terminal domain has an alpha/beta hammerhead fold.
Statistics
?
PSSM-Id: 397048
Aligned: 118 rows
Threshold Bit Score: 58.2706
Threshold Setting Gi: 501137462
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1X1O_A               27 GQGDLTSLLVVpEDLEGEAVILAKEGGVLAGLWVAERVFALAdpRT-AFT--PLVAEGARVAEGTEVARVRGPLRGILAG 103 Thermus ...
Q3J3H2               18 hpgvtvaEATShDSRGMTVTLRAGAAGTVCGLEEAERIFTLL--GC-AVD--IAAASGARVETDDLLVAARGPLASLTSG 92  Rhodobac...
rhodo:RCAP_rcc00565  18 PAGDLTTRSLGlAAEAGELTMRARGAMTVACSEEAVRILQLL--GA-EAW--IATASGRQVEGGEMLLFARGQVEALLAG 92  Rhodobac...
Q57278               18 YRGDLTTHALSiENIPAKILFKRKNAGVVAGVSVAEKLLKKL--DI-QPH--LYVKEGEWVESGALLISAEGMSEQLHQA 92  Haemophi...
Q32H18               18 QGGDLTTRALNiGHQHGYIEFFLRQGGCVSGVSVACKMLTTL--GL-TID--DAVSDGSQANAGQRLIRAQGNAAALHQG 92  Shigella...
AVZ42975             28 GYGDLTTRSLGiQDHPAHITFTARDEQIASSVEEAAALLKQL--GA-SID--YAIPSGSRALSGTLLLEAKASAGQLHLG 102 Zymomona...
Q2LXG7               20 QLMDVTTLSMGiEDLPGRLTCYPKRECVIAGVEEAACIFTKI--GA-EAE--IMIPSGRRVEEGKICLAVVGTAGMLHAG 94  Syntroph...
WP_014126184         14 GSYDLTTEVLGiGGLRGVAQLFAREEAVVAGSEEAAEVYRLA--GCgEVE--VVKRSGQLARRGNVVLRAVGEARCLHAA 89  Thermopr...
Q3ACM4                8 DIRDILF--SKiMQKHFTAQIKAENGGIIAGAQNAYNALKQL--GL-EIE--YFVYDGTEVQPETVIARFKGNPKQIAQA 80  Carboxyd...
Q1AWJ7               31 RAKGLENTPVHaEVAYKTSNPD--EWFVVAGLDEVANLLS----GL-EVEarAV-PEGTICGPHEPVLTISGPYGAFAEH 102 Rubrobac...
1X1O_A              104 ERLALNLLQRLS 115 Thermus thermophilus HB8
Q3J3H2               93 WQPAQSLIEWAS 104 Rhodobacter sphaeroides 2.4.1
rhodo:RCAP_rcc00565  93 WKVAQNLIEWAS 104 Rhodobacter capsulatus SB 1003
Q57278               93 WKVVQLVLEWSC 104 Haemophilus influenzae Rd KW20
Q32H18               93 WKAIQNVLEWsc 104 Shigella dysenteriae Sd197
AVZ42975            103 WKSAQSLMEWsa 114 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
Q2LXG7               95 WKVAQNVMEYAS 106 Syntrophus aciditrophicus SB
WP_014126184         90 WRTAQEVVAWAS 101 Thermoproteus tenax
Q3ACM4               81 EEVVMGYLMKTS 92  Carboxydothermus hydrogenoformans Z-2901
Q1AWJ7              103 ETAILGFLCQAS 114 Rubrobacter xylanophilus DSM 9941
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap