2BGW


Conserved Protein Domain Family
ERCC4

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pfam02732: ERCC4 
Click on image for an interactive view with Cn3D
ERCC4 domain
This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase. EME1 interacts with MUS81 to form a DNA structure-specific endonuclease.
Statistics
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PSSM-Id: 397032
Aligned: 152 rows
Threshold Bit Score: 35.0988
Threshold Setting Gi: 74605856
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2BGW_B        13 VD-VREersPVp---------SIl-------ESLG--V-QVIPKQLPMG------------DY------L---V---SDS 48  Aeropyrum pernix
Q8I409       206 ID-EKYl-kDQh---------EEyrhmfykiEKLQkeYrNVRIICILIGireilnrvdyteNYl-----Y---HdksFCS 266 Plasmodium falc...
Q7RJK5        79 ID-SNY---LEdqytseenniSYqik--klrEKYG--SvRIICIFIGIR------------EFl-----N---IidyTKh 130 Plasmodium yoel...
EDN64714     400 IEf-----sPSl---------LQlfk--kgdSDLQqqL-APAVVQSSYN------------DSm-----PllrFlrkCDS 445 Saccharomyces c...
Q6FM02       300 LDkQTEi--------------LKs-------------IlAPATIQKSIH------------DEl-----PrirFfrkCHS 335 [Candida] glabr...
XP_001642852 380 IP-------CSi---------LEefe--svcPNLR--S-LVAPATLQTG------------DSgnipliR---FlrkSDS 423 Vanderwaltozyma...
Q75B88       425 IN-EQVhqy----------llEQkvp---iaEVLG--P-TTVIHNFESV------------PIi-----R---FkrkCTS 467 Eremothecium go...
Q7JZM5        43 ID-AGF---LGi---------PVgqealqqlNATG--L-KYEIRSLPVS------------HCi-----L---WernVGQ 86  fruit fly
C5H8J1       258 ID-TKVl-eGSi---------GGlll--srfSEKG--I-TIHVGPNPIE------------RSi-----V---WtmtIPE 301 thale cress
Q84M98       249 ID-NKVl-eGSf---------GGlli--sglKEKC--I-TYHVTTNPIQ------------RSi-----V---WtmtLPE 292 thale cress
2BGW_B        49 --------------------IIVERKTSS--DF---AKSL-----FD---GRLFEQASRLa--eHYET------VFIIV- 86  Aeropyrum pernix
Q8I409       267 ssifsplkknkneiynekniMIINNKDLD--NI---IATL-----MV----HYYIDTAELdninQLTK------YIFKCc 326 Plasmodium falc...
Q7RJK5       131 pqicy----------ekndnIILNNKHLD--RF---IASL-----LI----QYNVDTVEIensiDIHK------YIFKCc 180 Plasmodium yoel...
EDN64714     446 iydfsndfyypcdpkiveenVLILYYDAQ--EFfeqYTSQ-----KK----ELYRKIRFFs--kNGKH------VILIL- 505 Saccharomyces c...
Q6FM02       336 fydlqhd------fffpsnyKIVEENTTI--LY---FDSKeffvkYKedkRSLFEKLKEIerdnYE--------IILVLy 396 [Candida] glabr...
XP_001642852 424 vydfnndi-----yypdqfkILDEKVYILyyDA---FNFF----------KQYRENKRKLf--kDIRFyikskkYIILVl 483 Vanderwaltozyma...
Q75B88       468 mydlnndiyypcettmcnepICLLFYNAV--DF---FTKY-----KNq-kQRLYSEVQDLk--rAGNK------VIIILn 528 Eremothecium go...
Q7JZM5        87 qtialgssptgldeawksenQVVQWLSES--SF---QRAV-----KD---QSLVCLGPRLq--dSFPD------CQYTIa 145 fruit fly
C5H8J1       302 diaplfp-------qgpkipYLLLVYDAE--EF---CNLV-----AN---GKFLEIISRVq--dRYPSy----tVCCLT- 354 thale cress
Q84M98       293 diaqslp-------lgskipYVLLLYEAE--DF---CNLV-----AK---KELLENVYRVr--dEYPSy----tMCYLT- 345 thale cress
2BGW_B        87 EGppvPRRYRG------------------------------------------RERS---------------LYAAMAAL 109 Aeropyrum pernix
Q8I409       327 KY---LHQSKYrkpysyfkvkp---------------------qtinhlknidINHKknn---------nstWTSQLMQI 373 Plasmodium falc...
Q7RJK5       181 KY---LHQSKIrklnsyfkvkp---------------------agimsqfkndNLNEnkt---------yytWVSQLMQI 227 Plasmodium yoel...
EDN64714     506 SD---INKLKRaifqlenekykarveqr--------lsgteealrprskkssqVGKLgik---------kfdLEQRLRFI 565 Saccharomyces c...
Q6FM02       397 DLa-kFKRELEkieetkyrsrv---------------------qsqiydsqqsIQQNkvttpqsdyglkkfdVEQRLRYI 454 [Candida] glabr...
XP_001642852 484 YG---LSQLKRdldnlennkykarvnehlsksplksptkksnqsnqskkteklQNLNmrs----------ndIEQRLRLI 550 Vanderwaltozyma...
Q75B88       529 EYs-rLEKSLAelenrcmrsrveqqltgd-------ksprrktvkevqltaleMNSK---------------DLGRKVNE 585 Eremothecium go...
Q7JZM5       146 -----LPTLRHs----------------------------------------kHGSSs--------------SQDALIEM 166 fruit fly
C5H8J1       355 NK---LMSYVKkrekeey-----------------------------knpgnwRRPP---------------IDEVLAKL 387 thale cress
Q84M98       346 NK---LLSYVNkkerveyk---------------------------dpvngcgWRKPp--------------IDEAIAKL 381 thale cress
2BGW_B       110 QLDY-GIRLMNTMDPKGTALVIE 131 Aeropyrum pernix
Q8I409       374 NGISeDVSKKITQVFNSPFHLMT 396 Plasmodium falciparum 3D7
Q7RJK5       228 TGISqDIAIRIAEEFNTPFDLIV 250 Plasmodium yoelii yoelii
EDN64714     566 DREW-HVKIHTVNSHMEFINSLP 587 Saccharomyces cerevisiae YJM789
Q6FM02       455 NREW-GLKIHIVNSHNDFVHSLP 476 [Candida] glabrata CBS 138
XP_001642852 551 DRLW-NVKIHTVNSHIDFLNSLP 572 Vanderwaltozyma polyspora DSM 70294
Q75B88       586 MIIKcDIDIFPINSAASFANWIS 608 Eremothecium gossypii ATCC 10895
Q7JZM5       167 QLLQ-ELHVEQLDQ-PESQDLVA 187 fruit fly
C5H8J1       388 TTHYvKVHSRHCVDEAEVAEHIV 410 thale cress
Q84M98       382 STHYiGVHSRHCVDEAEVADHVV 404 thale cress
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