5DGO


Conserved Protein Domain Family
CDC45

?
pfam02724: CDC45 
CDC45-like protein
CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus, among others.
Statistics
?
PSSM-Id: 397026
Aligned: 114 rows
Threshold Bit Score: 343.754
Threshold Setting Gi: 75031595
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5DGO_A        19 VLLFVA-SDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF-------LEH--K-------EQFH-----YFILIN 76 
Q4Q3V5        25 INVLVA-PTADAAAASLSLTYLMKVFLFPFQLHPTSSYDELKWFI-------EQAnfAqds-ereDDISlriddLFILVG 95  Leishmania major
XP_002009890  19 ILIIVN-YDVDAICASKILQSLFKYDHMLYTVVPIMGVTGLKRAY-------SEHqaD---------VK-----YVLLIN 76  Drosophila moja...
XP_001696501  27 vmCFAAcTDADSVCASQQLMNLFNREGIFFTLIPVDSYEEVKAHC-------EPLvqA-------EEVK-----TVVLIN 87  Chlamydomonas r...
XP_002989665  26 lhilpStVDADSVCALKIFRSILNADNVRHSVFPVSRMADVGSRA-------AAIqaE--------EPV-----VVLLIN 85  Selaginella moe...
XP_006663773  29 lliLPSaADADALCALKVLTHVLSADSIRFSIYPVASAAAAASLL-------ASFsaS--------QPL-----CLLLIN 88  malo sina
XP_020187916  32 lliLPSaADADSLCALRILAHVLSADSVRFSVYPVASTADAAELL-------ASFsgAtassplsPPPL-----CVLLIN 99  Aegilops tausch...
EES07916      30 VLILPSaADADSLCTVRALAHVLAADSVRFSVYPVASAAAARALL-------ASFsaSas----asSPL-----CLVLVN 93  sorghum
KRH46661      25 VLIFPStSDVDSLCALKIIFHILESDSIQYACYPVSSFHEIHKYT-------NSSsnD--------EPL-----SVVLVN 84  soybean
EFH59832      27 llifPStSDVDSLCALKVITHILESDSIQYSCFPVSSFLEIHKYAgpaglcsTSSesP---------PV-----TILLIN 92  Arabidopsis lyr...
5DGO_A        77 CGANVDLLDILQPDEDTIFFVCDTHRP-VNVVNVY-NDTQIkllikqdddlevpa--------------------yedif 134
Q4Q3V5        96 LGAPVLLEDYFDFT-RHIVIVLDAYRP-FHLGNLCredgdrciiwgsdriqvevddffrkq--raeeaqrrrrhrrrldm 171 Leishmania major
XP_002009890  77 CGGCVDIVELLQPAEDVTFYICDSHRP-LDVCNVY-SDRQVcilgdpaleenipgfes-------------ifydseged 141 Drosophila moja...
XP_001696501  88 CGATDDIRSLCELPDNVRIVIIDHHRPvWHGHNVe-DDTNTlvlvdeddpvpkasvpvynpn-----eqeedeedsgsea 161 Chlamydomonas r...
XP_002989665  86 WGGTQDLRRQLKLGPRVLVFVVDSHRP-IHLNNWSdHNQQVtvlytreeemerdivydfdvg-----sladfsfmtaasd 159 Selaginella moe...
XP_006663773  89 WGAHRDL--RAVLPPAATAFVVDSHRP-IHLHNLSaANDRVvvlfttddehtadlsydfdvssl-adasdlsaqgdaddh 164 malo sina
XP_020187916 100 WGARSDLLRGI-LPRGSTAFVVDSHRP-VNLRNLAaGNDRVivlftadderaadlsydfdassla-dasdltaegdaddd 176 Aegilops tausch...
EES07916      94 WGAHWDLVRAAVLPDTATAFVVDSHRP-VHLHNLCaRNDRVvvlftaddeqaadlsydfdlaaladasdlaaegdadadp 172 sorghum
KRH46661      85 WGNHRDLSNTLNLPSNARVFVVDSHRP-IHLRNLSdQNDAVvvlftkedegqsdlayd-------------fdlttlana 150 soybean
EFH59832      93 WGCHRDLKLVLKLGPAARVFVVDSHRP-IHLHNLSdYNEQVvvlhtddderqadlaydfdvlk----lanesfqlhveeg 167 Arabidopsis lyr...
5DGO_A       135 rdeeedeeHSGNDSDGSEPve-------------------------------------qtMRRR---QRREWEARRR--- 171
Q4Q3V5       172 krhegharRQRTEGGGAQDddvysdessistsseeeesadsdgdeaadlfdgedddatpsqsqdrvdWRSAPGEVPA--- 248 Leishmania major
XP_002009890 142 gdddddedEDGDENGDSGAgesddgngdgdss----------------ervrapklsrmqKHEQrilRQRARRQWESerd 205 Drosophila moja...
XP_001696501 162 seaekddeEDQEAGVSGDGdededdlgvrpgrkrrrrstgadq-------------eerpakrspearaqaraerrklae 228 Chlamydomonas r...
XP_002989665 160 geededeeESDDEEELDGGgggdkhdnmrkrgrgrgrd---------------------------dssdhadnlrrdmrr 212 Selaginella moe...
XP_006663773 165 lrvaeedeDSDDSDSDSDAeggrrkrrrlsddad-----------------------------------adgdperlfgk 209 malo sina
XP_020187916 177 hlraseeeeSDTSDYDSGAeggrrkrrwasddaea----------------------------------dgddpvrlfgr 222 Aegilops tausch...
EES07916     173 lraasgsdASDYEDSDADEdedvsggggrrkrrrlsdd---------------------------adadadsdpvrlfgr 225 sorghum
KRH46661     151 attvdsdsDSESESESDSDsdsgsertgsrkrrkknpqd--------------------------dddgddedpiklyrk 204 soybean
EFH59832     168 gesdeeeeEEEDEEEEDEDdddddgdgdrpskrr-----------------------------------kmgdgvkvfkk 212 Arabidopsis lyr...
5DGO_A       172 DILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQ------RHVSRHNHR- 244
Q4Q3V5       249 YLEALYYACSCAGRSSAVEVYDLSVILHRFNDTILWHAAVGVCDLYLRRLVDYATYLVEMGPLEeavslqQSVRRgil-- 326 Leishmania major
XP_002009890 206 RIMFDYTQFSYYGRSTALYIFELAWKLSKDNMDLLWWAIVGISEQLLLGKIESAAYTLELENIQ------SHVSRLTNk- 278 Drosophila moja...
XP_001696501 229 LIDAYYSDCNGYGKPSSLLLFALVNTAQHDDNFHLWCAIVGLTEQLLFHQISKQQYNTWREGLE------QKTHVqadp- 301 Chlamydomonas r...
XP_002989665 213 rkkdYYSTGTFHGRAAGRQVYDISHALHINTHELLWLACVSLTDQFVHERLTMERYQSGVMELD------TYVKT---Sg 283 Selaginella moe...
XP_006663773 210 lrreYYRLGTFHGKPSGCLMYDLAHAMRKNTNELLWLACVSLTDQFVHERITNERYQAAVMELE------QHING---Sg 280 malo sina
XP_020187916 223 lrreYYRLGTFHGKPSGCLMYDLAHALRRNTNELLWLACVSLTDQFVHERITNERYQDAGMELE------QHING---Sg 293 Aegilops tausch...
EES07916     226 lrreYYRVGTFHGKPSGCLMYELAHALRRNTSELLWLACVALTDQFVHDRITNERYQAAVMELE------QHVNG---Sg 296 sorghum
KRH46661     205 lkkgYYKLGTFHGKPSGCLMYELADKLRKNTNELLWIACISLTDQFVHERLSDERYHDGVMELE------QHINS---Sg 275 soybean
EFH59832     213 lkrdYYKMGTFHGKPSGCLLFELSHMLRKNTNELLWLACVALTDQFVHERLTDERYQAAVMELE------QHINS---Sg 283 Arabidopsis lyr...
5DGO_A       245 ------------NEDEENTLSVDCT------------RISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWS-VHGQKR 299
Q4Q3V5       327 ------------------rdRTDEAvnsyhrastnsmQLSNREEEQLYLLRHSTLWDAIWYDSQVASALDLHHvEDGRPR 388 Leishmania major
XP_002009890 279 --------------------TNDQNtms-------asKINFENDLHLVLYRHWTVTESMRYSRYSACKLKLWT-LRGEKR 330 Drosophila moja...
XP_001696501 302 -----------------qeeLDNEAangllhiprqkvHVEPFDDLRLTLLRYWTIEDSLRYTGYVAARLQTWR-QKGLDN 363 Chlamydomonas r...
XP_002989665 284 nsem---vtkvtMKDGTVVKAPDRS------------RITNDEEPRLMLLREWTLYDSMLCSSYVATKLKTWS-DGGLKR 347 Selaginella moe...
XP_006663773 281 nldpsgvgsvvtLKDGTKIRAPEAS------------RIAYEDEPRLMLLREWSLFDSMLCSSYVATKLKTWS-DNGLKK 347 malo sina
XP_020187916 294 nldpsgvgsvvtLKDGTRIRAPETS------------RIAYEDEPRLMLLREWTLFDSMVCSSYVATRLKTWS-DNGLKK 360 Aegilops tausch...
EES07916     297 aldpsgagavvtLKDGTKVRAPEAS------------RIAYEDEPRLMLLREWSLFDSMLCSSYVATKLRTWT-DNGLKK 363 sorghum
KRH46661     276 nlda---vtsvtLKDGTKIRAPNSL------------RITYEDQPRLMLLQEWSLFDSMMCSSYIATKLKTWS-ENGIKK 339 soybean
EFH59832     284 nidk---itsvtLKDGTKVRAPDCS------------RISYEEEPRLMLLREWTLFDSMLCSSYIATKLKTWS-DNGIKK 347 Arabidopsis lyr...
5DGO_A       300 LQEFLA-DMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGM--KDMRVQ---------------TFSIHFGFKHKFL 361
Q4Q3V5       389 LSQLLAsRCGVSIAMAQRPWCEVPTDVGSEALRRVQ----------VELQNWvnaqgnfiayrnrirCISRKVGYSTEVS 458 Leishmania major
XP_002009890 331 LHELLV-EMGLPLVHARQTYSAMDLILRKEFYSMVEQLAEKYGI--PDIVYG---------------TFTLSYGYRSRYA 392 Drosophila moja...
XP_001696501 364 LRSLLT-YMCIPLKHATTAYKGLREVYNSQLRAQLPRFAPQHMLawDSLHLS---------------SFRLLYKHE-EIS 426 Chlamydomonas r...
XP_002989665 348 LKLLLA-TMGIALVEGQQKYEYMSGETRRRMKEEFQRSSPQFGL--TDLYYR---------------SFQKLHGYSSEVS 409 Selaginella moe...
XP_006663773 348 LKLLLA-RMGFPLADCQKRFQYMSMEVKRKMRDEFDRFLPEYGL--TEFYYR---------------SFLRVHGYRSKVS 409 malo sina
XP_020187916 361 LKLLLA-RMGFPLADCQKGFQYMSMEVKRKMRDEFDRFLPEYGL--TEFYYR---------------SFLRVHGYKSKVC 422 Aegilops tausch...
EES07916     364 LKLLLA-RMGFPLADCQKSFQYMSMEVKRKMRDEFDRLLPEYGL--TEFYYR---------------SFLRVHGYRSKVS 425 sorghum
KRH46661     340 LKLLFG-TMGFALGDCQQKFQHMNLEVKRKMKKEFERFLPEYGL--TDFYYR---------------SFIRTLKYSSKIS 401 soybean
EFH59832     348 LKLLLA-RMGFALIECQQKFPYMSHEVKRKMKQEFDRFLPEYGL--NDFYYR---------------SFLRLHGYSSRVS 409 Arabidopsis lyr...
5DGO_A       362 ASDVVFATMSLMES----------------------------PEKDGSGTDHFIQALDSLSr-sNLDKLYHGLELAKKQL 412
Q4Q3V5       459 TFDVCKLFTAEMAAvppasvyvierspanaslspeevaalaqRKLVEFQRGQFWRASAVLDidpNEKLFHEALAGALSLQ 538 Leishmania major
XP_002009890 393 AADYVYALLAILQS----------------------------VKKHKTPEDCFMEASDALSr-qHKQLLNVGIDNAKLLH 443 Drosophila moja...
XP_001696501 427 ASDMVFALLGLLTDa--------------------------kPKEKSWHRAAFNDASNALHvqrNLNVVEKGIELAKRMC 480 Chlamydomonas r...
XP_002989665 410 AADVVYGLTALLEAs------------------------------cDDHGGQFMRAYSALAp-kKWHELQQGMELAIKVQ 458 Selaginella moe...
XP_006663773 410 AADVVYGATALLESlna----------------------eskDSKGSSAAEQFWVAYSALSl-sNVDQLRKGMQSAIEIQ 466 malo sina
XP_020187916 423 AADVVYGVTALLECmsa----------------------esnDSKECSAAEQFWVAYSALSp-sNVDQLQKGMQSAIEIQ 479 Aegilops tausch...
EES07916     426 AADVVYGVTALLESlna----------------------eskGSKESSAAEQFWAAYSALSl-sNVDQLQKGMQSAIEIQ 482 sorghum
KRH46661     402 AADVVYGVTALLESf--------------------------vRSDGSCASKQFGVAYDALSl-nNIDNLRTGMHHAIKIQ 454 soybean
EFH59832     410 AADVVYGITALLESf--------------------------lGSGGSSASKQFGEAYDALSl-nNLDKLRSGMQQAIKVQ 462 Arabidopsis lyr...
5DGO_A       413 RATQQT-IASCLCTNL-VISQGPFLYCSLME--Gt-PDVM--LFSRPASLSLLSKHLLKSFVCSTKNRRc---kLLPLVM 482
Q4Q3V5       539 QAVADA-TGSMMQPGN-VQSSTGIHYALPSDpsKtsPTLE--SFCTMRRLSVLAERLFFTLSMSRRRDRraltaLRPLIL 614 Leishmania major
XP_002009890 444 AAIFRQ-VQSCLEAHQ-VHSTGSFFYYVLQE------EHA--FFSYPYALALLAKFVLHGHVATTRVRQa---pDLPLIA 510 Drosophila moja...
XP_001696501 481 SDVVHEcGLMITSGKVkGGRNADYRWVNVAE--S--NGLAnpRFTHPAVLKYMALFLRDATSHRYSSNDa----RRPMVV 552 Chlamydomonas r...
XP_002989665 459 RAILRQ-GSLAVTKQGfVKNTKMFRWFKLED--G--HDVE--LLARPMALTKLCYFVMDALREQGAR-------SKPLVC 524 Selaginella moe...
XP_006663773 467 RAILRQ-GSSAITKTGfIRSAKKFRWVKLDD--P--VDTD--KLCHPQALTKFCFFLMDALKERGAR-------MKPLIC 532 malo sina
XP_020187916 480 RAILRQ-GSSAITKSGfIRSAKKFRWVKLDD--P--VDTS--KLCHPQALTKFCFFLMDALKERGAR-------TKPLVC 545 Aegilops tausch...
EES07916     483 RAILRQ-GSSAITKTGfIRSAKKFRWVKLDD--P--VDTS--KLCHPQALTKFCFFLMDALKERGAR-------MKPLIC 548 sorghum
KRH46661     455 RAILRQ-GSAAITKNGcIRSGRSFRWLKLED--S--NDAT--LLGYPQALTKFCYFIMDALREKGAK-------MKPLIC 520 soybean
EFH59832     463 RAILRQ-GSAAITKTGcIRSGRKFRWVKIED--S--MDAK--YLGYPQALTKFCYFLMDALREKGAR-------MKPMLC 528 Arabidopsis lyr...
5DGO_A       483 -AApLSMEHGTVTVVGIPPETd------sS--------DRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFL 547
Q4Q3V5       615 sCV-LPQAR-----LAAPPTAssgsgsglPcgpgtdalVPAVHWSRASGGVPSASAATAAGGVFMGGGAQV--EDTAEYV 686 Leishmania major
XP_002009890 511 tCP-LDASQGMCLLVGIAPvr-------eD--------SPKNFFGKAFDQAAQKSKTNLLQDFFEPSIVQLRQSDLTRFL 574 Drosophila moja...
XP_001696501 553 -AG-PPDEGGMCCVVAVHAKHisgn------------klqKNPFARPFIETASALHIFQQKSAFENTTFHLRKEEVGPFL 618 Chlamydomonas r...
XP_002989665 525 -AI-RCPQSDKALVVGVSHRLrlg-------------aqmGNRFGSVFKTVAANLGVDFQQDGFDAAWIQTDAASVGAFM 589 Selaginella moe...
XP_006663773 533 -AC-LSREPEKVLVVGVCGKPrlg-------------avkGNAFGNAFRSAAEEIGADYFHDMFESSWIVLDVVAVSSFM 597 malo sina
XP_020187916 546 -AC-LGREPEKVLVVGVWGKPrlg-------------avqGNSFGNAFRSAAGEIGADYFHDMFESSWIVLDVVAVSSFM 610 Aegilops tausch...
EES07916     549 -AC-LAKEPEKVLVVGVCGKPrlg-------------aaqGNAFGNAFRSAAEEIGADYFHDMFESSWIVLDVVAVSSFM 613 sorghum
KRH46661     521 -AC-VSQEPGKVLIVGVCGRPrlg-------------gaqGNAFGIAFRTAAEEIGTEFFHELFESSWIVLDASAVNSFM 585 soybean
EFH59832     529 -AC-ASQQPGKLLVVGVCGKPrlg-------------avrGNAFGNAFRKAAQESRADYFHELFESSWIVLDASAVNSFM 593 Arabidopsis lyr...
5DGO_A       548 DAL 550
Q4Q3V5       687 VVL 689 Leishmania major
XP_002009890 575 DAL 577 Drosophila mojavensis
XP_001696501 619 DRL 621 Chlamydomonas reinhardtii
XP_002989665 590 TQL 592 Selaginella moellendorffii
XP_006663773 598 IRL 600 malo sina
XP_020187916 611 IRL 613 Aegilops tauschii subsp. tauschii
EES07916     614 IRL 616 sorghum
KRH46661     586 VRL 588 soybean
EFH59832     594 IRL 596 Arabidopsis lyrata subsp. lyrata
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap