Conserved Protein Domain Family
DUF222

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pfam02720: DUF222 
Domain of unknown function (DUF222)
This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.
Statistics
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PSSM-Id: 397024
Aligned: 19 rows
Threshold Bit Score: 189.88
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q73VY1         38 LRALERMEASRRRQIAVSHGVIAGL------AGEGPGNVGGP-VHKVIADRLRISYAEACRRLREAKQLSPRltltgqel 110 Mycobacterium ...
Q0RL20        111 DGAVLDCSALLARLAAVRVGLVREMr-----GRGSALREGATsTAALVRARLRIRPVDAQRLVDLALAVDDD-------- 177 Frankia alni A...
jgi:Mvan_0040  22 FEELSELAGQRNAIDGRIVEIAAQId-----RDGLVGITGARsVAALVAWKTGCSPHNAKTITTVADRLEE--------- 87 
Q743Z8         17 STHREESMLVARRFAAVAALLRHRVattdrpEPEYAEIDGFEqTAAEVAAAMNLSAAAASYLVSYAETLDTR-------- 88  Mycobacterium ...
VBC:MMAR_1213  34 AAARAEARAAAERLAAIGDLFRLRLsq--hgNREDWVADTCDaVAAEVAAALNTSVAMGHSNLRYARAMRER-------- 103
O33360         34 SATRAENRAAAAQLVALGELFAYRWsr--cgGREEWVMDTMAaVAAEVAAALRISQGLAASRLRYARAMRER-------- 103 Mycobacterium ...
Q73S99         33 vfARVENRAAAEQLAAIGELFAYRLsr--csECEDWAVDTEAaVSAEVAAQLRIGQGLAAAKVRYARAMRER-------- 102 Mycobacterium ...
WP_012393989   23 EASRREAAAAAERLDVVGALFVLRCre--sgDRAEWATDTWEaVAAQVAAALRTSVAMGSSYLRYAMAMRNR-------- 92  Mycobacterium ...
Q741N7         31 EAARAEARAAAARLVAIAELLVLRCre--tgERADWAADAWEaVAAQVGAALGCSVAMGHSYLRYAMAMRER-------- 100 Mycobacterium ...
WP_011780947   16 SAARAESAAIARRLEAVAALFRSRKcd--yaEAGFLHTDVYEaVAAEVSAAQNISRSRAGYQVEMAVSLYTR-------- 85  Mycolicibacterium
Q73VY1        111 ppeLPATAGVWREGMLDGQHLRVIEKFVRDLPETTPVRALEEAERFLAHQATLLRPDQLEKVAHQCALRI---N------ 181 Mycobacterium ...
Q0RL20        178 ---LAATGAALIAGTISVEQAQTIHLALRSLPRGVDVATRRSAEQFLLTSAARFDPAELARLGRHLRERLtdvDtspggd 254 Frankia alni A...
jgi:Mvan_0040  88 ---FPRCVTALGEGRLSLDQVAVIAEHAGQGSDAHYAHLAASASVSQLRTAVKSEPRP---------------D------ 143
Q743Z8         89 ---LPEVAALLAEGRTDWRTVRLIITRTSLVTDTELIAKLDRSLAARIGNWHGWSRQRIVNAVDAAVRTA---D------ 156 Mycobacterium ...
VBC:MMAR_1213 104 ---LPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAKF---D------ 171
O33360        104 ---LPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLAGQVDKIVARA---D------ 171 Mycobacterium ...
Q73S99        103 ---LPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVAKA---D------ 170 Mycobacterium ...
WP_012393989   93 ---LPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVADV---D------ 160 Mycobacterium ...
Q741N7        101 ---LPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDATLAVLVSRRPSLTRGGLAAAVDRVVAAV---D------ 168 Mycobacterium ...
WP_011780947   86 ---LPKVAEAFARGDIDLRMVQIVLARTKNV-EDDVIGGLDKAIAPKLSRWMRLSKNDLRDRVDLWVADF---D------ 152 Mycolicibacterium
Q73VY1        182 -------------------------PDGKF-----SDADRAR-------QRGFTWCGq-RADGMSFGKLWASPELRANLD 223 Mycobacterium ...
Q0RL20        255 npdpedngagnndgagnadadsdspPDGGEgagrsATSGAADgdgdpadRRRLWITD--LSDGMTRISGELDAEAAALLR 332 Frankia alni A...
jgi:Mvan_0040 144 -------------------------PEPVRdpfadADEEPEPap---vpRPEITSTC---DADYTYWRIKLPHEQSARFT 192
Q743Z8        157 -------------------------PDAARe----RRLAAEE-------DRHIGISA--AENGMAEVHGSVAAAAATAFD 198 Mycobacterium ...
VBC:MMAR_1213 172 -------------------------RDAVR-----RSRRDAA-------DRYVDCAP--LEPGMALVNGQVFAATAEALA 212
O33360        172 -------------------------ADAVR-----RRKEYQA-------QRQFWVGE--SQDGVCQIGGSLLAVDAHALD 212 Mycobacterium ...
Q73S99        171 -------------------------ADAVR-----RAEKQAA-------TRHVWIAE--MGEGLSHLEGTVSSPDAHALD 211 Mycobacterium ...
WP_012393989  161 -------------------------RDAVR-----RVAEAAD-------GRFVDVDViaDGSGLAALTGSVLATAGRAFD 203 Mycobacterium ...
Q741N7        169 -------------------------ADAVR-----RARDAVT-------GRYLDVRA--NESGMAWVEGNVLGPDGHALD 209 Mycobacterium ...
WP_011780947  153 -------------------------PAAVR-----VPPEAKD-------NRYFDVTP--DVPGMAFAGGLLNARDAAALD 193 Mycolicibacterium
Q73VY1        224 AWLARFAAPgMCNPDDeapcvagepDEESATKDSRTPAQRQHDALNALL----RGRLGDPKLGLHNGLP---------VT 290 Mycobacterium ...
Q0RL20        333 TALDSLAAP-MPAI--------------DGTPDPRSPARRRADALVDFV----HRALDASAVPISGGVR---------PH 384 Frankia alni A...
jgi:Mvan_0040 193 AALQSHKDR-LIAQHTrdhgtdptgDGDGDRGVQLPPWPSAGEAFMELV----EAGWDAEATRRPHGQH---------TT 258
Q743Z8        199 RRLSQLAKQ-VCPA------------------DPRTLDQRRADALAALAeg-rGLPCACGQPDCPARTGdqhaddgtgAR 258 Mycobacterium ...
VBC:MMAR_1213 213 RRLDELAKT-VCAD------------------DPRTVVQRRADALGTLAagqdRLICDCGRTDCPAAGApq-----qpSR 268
O33360        213 ARLSALAGT-VCEH------------------DPRSREQRRADALGALAggadRLGCGCGRADCAAGKRpa------aPP 267 Mycobacterium ...
Q73S99        212 KRLDALAAT-VCEH------------------DPRTGEQRRADALGALAagadRLGCRCGRADCAAGTGpa------aGP 266 Mycobacterium ...
WP_012393989  204 RRLDELANT-VCAA------------------DPRTREQRRADAVGALVagsdRLACGCTSADCTAAARsa------pSN 258 Mycobacterium ...
Q741N7        210 RRLDELASG-VCAG------------------DPRSRAQRRADALGALAagagRLACGCGSPDCPSAAApa-----prST 265 Mycobacterium ...
WP_011780947  194 QRLEAIAAT-VCSN------------------DPRSHNNLRADAAGALGrgesTLTCECGAEDCPAAVLre-----saAQ 249 Mycolicibacterium
Q73VY1        291 VVVSTTLRELTTGAGR----AVTGGGTLLPMRDVIRMARHAYhyLA-VFDEhsSRPLY-LGRSRRVASPDQRVVLYAKD 363 Mycobacterium a...
Q0RL20        385 LTVTIPWTTLVGRGGPa---ASTSWGQPLSRATVRRLACDAA--VSrIILDpaSVPLD-VGRTQRTVPGDLRRALVARD 457 Frankia alni AC...
jgi:Mvan_0040 259 VVVHVDIDTRVAALHL---------GPLLTDEERRFLLCDAT--CE-VWFQrhGRPLG-TGRSTRTINRRLRRALEHRD 324
Q743Z8        259 VVINVVASDRTVYADGaepgYLEG-YGVIDADQVRRLAAAAH--LL--VANpaTSP---AAALRYQPSAALERAVRCRD 329 Mycobacterium a...
VBC:MMAR_1213 269 VVIHVVAGRETVDGAGeapgVLPG-DGIIPAEIVRELAKSAK--LQp-----mSTPI--LAETGYVPSPALMDFVRARD 337
O33360        268 VVIHLIAEAATINGTGsapaSQMNADGLITAELVAELAKTAT--LVp-----lVHPGDaPPEPGYAPSKALADFVRCRD 339 Mycobacterium t...
Q73S99        267 VVIHVIAERASVEGTGggpaVEVGAEGLLPAQLVAELAASAR--LMp-----lVHPADsSPENRYTPSAALADFVRCRD 338 Mycobacterium a...
WP_012393989  259 VVIHVVADQSTVDGTGhtpaVLLGAEGLIPASLIAELAKVAT--LRp-----lMRPSG-RPESGYAPSAGLAEFVRCRD 329 Mycobacterium m...
Q741N7        266 VVIHVVAEQATVAGRGatpaVVAGLDGLIPAQVIAELAASAR--LVp-----vAVPEG-GPEPGYTPSARLADFIRCRD 336 Mycobacterium a...
WP_011780947  250 VVIHILAEQATVDGDGdkagYLPG-FGVLPAEEVRAAAKTAK--LKp-----vRLPGA-EPEKGYRPSAGLKDFLQWRD 319 Mycolicibacterium
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