Conserved Protein Domain Family
DUF218

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pfam02698: DUF218 
DUF218 domain
This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes SanA, which is involved in Vancomycin resistance. This protein may be involved in murein synthesis.
Statistics
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PSSM-Id: 397011
Aligned: 555 rows
Threshold Bit Score: 49.9465
Threshold Setting Gi: 255344596
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBBU:CRES_1747 119 DAIIVLGagltgrkpsPvlarRLDRAAqvarqlEAIRPAvvagqqgvIIVSGgq-----------------gAdePCSEA 181 Corynebacteri...
CDD30010        23 DAIFLPG---------GthaeQPEYAA------ALYRQGyg----kwLIPSGgvsvkkerwp-gvsskadvyTgdYHTDC 82  Firmicutes ba...
CDB18534        26 DAIFIPG---------CarpeHTEEAA------RLYKDGya----plLLPSGgytkvqgsfq-gvskegqkyGadFACEA 85  Eubacterium h...
CDE46744        29 DVILIPG---------SrhpaNAIRAA------ELYRAGya----pyVLPSGrhgaavdkfigvmpedraayPddYPTEW 89  Faecalibacter...
CBL22417        23 DIIFIPG---------NgysqMAEKAA------ALYGEKya----pfVLPSGkysitvdkfc-gvlsgqeryNgnYRTEW 82  Blautia obeum...
CDB20442        31 DIIFVPG---------NgfpqMSIEAA------RLWKEGma----pwILPSGkysigkgaft-gvqvmkekyQgpYQTEW 90  Blautia sp. C...
XP_018158160    29 TAVFCLc---------SldkrVAARAA------QLFLDGyg----eyLIYSGgvgklt-------------egrftEPEA 76  Colletotrichu...
XP_013947292    30 DAIFCLc---------SldtrIAAHAA------QLYLDGla----pyLIYSGdsgalt-------------kglfsEPEA 77  Trichoderma a...
WP_012091038    26 DVIIGLG---------SydprVAERAA------DLFLAGma----twLVFTGksghwt-------------drlykASEA 73  Ochrobactrum ...
Q2YQW3          26 DIIIGLG---------SydprVAERAS------DLYLEGla----pwLIFTGrsgrgt-------------dklykASEA 73  Brucella abor...
CBBU:CRES_1747 182 EAMARYLRtEAQLGgAdsrweVLQEDEATSTEENLANSTR-ILqerragtsgtntgtpgtntanpgsrtkrddemctIVV 260 Corynebacteri...
CDD30010        83 AFFIDVLRkNGVPAsA-----IVGEFQSGHTRDNAFLSRQ-AVdekgl-------------------------vfrtALI 131 Firmicutes ba...
CDB18534        86 DFLEAVLIqNGVPAsA-----ILKECEATYTLENAEKTKV-LLekkdi-------------------------hlkkAIL 134 Eubacterium h...
CDE46744        90 AFLRDVLIkHGVPDsA-----ILREDEATFTWDNARKSAA-VLkaqgi-------------------------sartAIL 138 Faecalibacter...
CBL22417        83 EFLKDVLVkNHVPDeV-----ILKEDQATFTWENARLSRE-VTdkagi-------------------------eikkALL 131 Blautia obeum...
CDB20442        91 EFMKDVLLkEGVPEeV-----ILREDGATFTYQNAINSRK-VTdavgi-------------------------rvkkAII 139 Blautia sp. C...
XP_018158160    77 EVFAGIAGkLGVPDdK-----IIVEPRSGNTGENVRFTYD-LLkqrgl-------------------------gtksFVL 125 Colletotrichu...
XP_013947292    78 VVFAAIAReMGVPEdK-----IIVEPRARNTGENVRFTYA-LLkergl-------------------------efnkLVL 126 Trichoderma a...
WP_012091038    74 EAFAEIAIrRGVPEeA-----ITIEPNATNIGENIRFSRErLApga-----------------------------isAIL 119 Ochrobactrum ...
Q2YQW3          74 EAFAEIAIrRGVPErA-----IIIEPNATNIGENIRFSREkLAwda-----------------------------vsGIF 119 Brucella abor...
CBBU:CRES_1747 261 VTSDFHVPRTR--W-HAKhaerdfpgvayrvvgaetPAgar------paAY----------VREYV 307 Corynebacterium resistens D...
CDD30010       132 VCKAFHARRCLmlY-QLAfpdvsfkv--cpvpcyniTKenwykteaglhRV----------LGELA 184 Firmicutes bacterium CAG:94
CDB18534       135 CCKAHHSRRSYlyY-SMVfpeieilv--ypvvvdgiSRedwyktaegrkVV----------LGEFs 187 Eubacterium hallii CAG:12
CDE46744       139 CCRPFHARRALlyY-QTAmpetrflv--cpareegvNQddwyltqagrtRV----------MGEvr 191 Faecalibacterium sp. CAG:74
CBL22417       132 CCKNYHARRALmyY-QRAypeaefrv--cpccvdgvTKenwmnaeesiqSV----------LGEVq 184 Blautia obeum A2-162
CDB20442       140 CCKAQHARRCKlyY-QYLypqttfli---cpsdvgiNRenwfdtqkgrkEV----------LGEve 191 Blautia sp. CAG:52
XP_018158160   126 VQKPYMERRTYatF-RKQwpdeatnf---tvaspslEFeeypdadnpkeLVinimvgdlvrIREYP 187 Colletotrichum higginsianum...
XP_013947292   127 VQKPYMERRTYatF-RKQwpdeataf---tvsspklSFdeypdasntreLVtsimvgdlirIREYp 188 Trichoderma atroviride IMI ...
WP_012091038   120 VTKPQTQRRVLatAaRQWpearas------itaplvSFedqptadhpveML----------ISEMT 169 Ochrobactrum anthropi
Q2YQW3         120 VTKPQTQRRVHatMlRQWpearas------isaplvSFeeqptaefpleML----------IHEMT 169 Brucella abortus 2308
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