Conserved Protein Domain Family
Na_Pi_cotrans

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pfam02690: Na_Pi_cotrans 
Na+/Pi-cotransporter
This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.
Statistics
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PSSM-Id: 397008
Aligned: 473 rows
Threshold Bit Score: 49.7038
Threshold Setting Gi: 351705282
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX87382        15 LFLYGMSLMGSSLEKLA-GSGLERILEKLTTGKrkgigyVKGWGLGAGVTAIIQSSAATTIMLIGFVNAGIMKLYQAIPV 93  Clostridium s...
WP_117606340   155 iLMTGMQTMSGAVAPLReSKVFMDLLTTFS-NP------VIGILVGIVFTAILQSASATVGVLQALSVTGLLTFSSAFPI 227 Dorea formici...
WP_003535704     1 -----MHLMSTSLDTLA-NDKLENILYKLSSNK------YLGVITGTAITAIIHSSSATTIILIGLLNSHLISLNQATWI 68  Erysipelotric...
WP_012062830    14 LFLLGMQFLTKGLNHLT-STRVKSLIQNIKIHP------VVGVLIGALITGLLQSSSGATIIFVGLVEARLLTLHQVAPM 86  Alkaliphilus ...
WP_012159870    14 LFLLGMNFLTEGFNNFI-SHRLKNIILNLKVYP------IVGVLIGAIATAILQSSSGITVILVGLVHANVLTLHQATPI 86  Alkaliphilus ...
CDB23648        19 LFLLGIREMTQSLEKVS-DSFIKDTIDKFTKNK------YMAAFIGVIITVIVQSSSAVTVIVVGMVEAGLMALNQAAAV 91  Clostridium s...
WP_003518407    18 cIVYGVKLMSSSLEKAN-IRRMKKYLSLFTEKV------PLATLTGTVLTALVQSSTAITVITVGLVNSGMLKLTQAVGI 90  Hungateiclost...
WP_013121039    13 LLLFGMQFMKTGLENVA-QRRMRQALHTLTRTA------AMGTLAGTIITMLVQSSTAITVMTIGLVNARVISFTQALGI 85  Thermincola p...
WP_006520385    13 MLLWGMQIMKEGLENLS-REKMRQALATLTATP------LKAALTGLVFTILAQSSTAMSVITIGFVNAGLMNLAQAIGI 85  Desulfallas g...
jgi:Hore_08740  10 FFLAGLEGSKKSLTKLA-LKRVELLLKKLSDNN------LLSLLVGVVSTAILQSSSGLTVIVISLIESGYLALKPAVLI 82  Halothermothr...
CCX87382        94 VMGANVGSTVTAQILrlgdlgsdnlilkLLKPSSFAPMLVGVGAF--ILLFT----K-KkKAKDIAGILVGLGVLFYGMT 166 Clostridium s...
WP_117606340   228 ILGIGVGASCPVLISaigan------kngkrTALVYLLNDTFGMLlwSIGFYi------------iNAFVHFSFLNtimt 289 Dorea formici...
WP_003535704    69 ILGANIGTTVTGLMI-------------ALDLGQSAIYLCVLGLL--LMFLK----N---KIAYLGRVLMALGLIFLAMD 126 Erysipelotric...
WP_012062830    87 IMGSNVGSTLTAQLI-------------AFNLGQYAPIIFIIGII--LTLF-----KnR-RAIVVGQSAVGFALIFIGIT 145 Alkaliphilus ...
WP_012159870    87 LMGANIGTTMTSQLL-------------AFNVDQYAFIPFILGML--IILTT----KnK-KLKYFGNICLGLSLIFIGIN 146 Alkaliphilus ...
CDB23648        92 IMGANIGTTVTSLII-------------AINLLSLAPLFIFGGVV--FVFF-----KnK-FLKTLGSILTGFGILFLGMN 150 Clostridium s...
WP_003518407    91 IYGANIGTTITAQLM-------------SFRLTNFSYIIIGLGLL--IAFFS----KrR-TPANMGWALTGLGIMFAGLN 150 Hungateiclost...
WP_013121039    86 VLGTNIGTCITTQII-------------SFNLNDVALPAIGLGAI--IMTWS----RrK-GWYYLGQSIVGFGIVFLGIG 145 Thermincola p...
WP_006520385    86 LLGANVGTCITVQLL-------------SFNLFHLAAPAAALGIV--FWALL----GnR-PAGQLGRSLCGFGLVFAGLQ 145 Desulfallas g...
jgi:Hore_08740  83 IMGANIGTTLTVHLI-------------SLPIISYYSCIIISGLV--VAIIGlfvnK---KVFFGGLSLFCFGTAFAGLH 144 Halothermothr...
CCX87382       167 TMES 170 Clostridium sp. CAG:590
WP_117606340   290 pvsi 293 Dorea formicigenerans
WP_003535704   127 SMAv 130 Erysipelotrichaceae
WP_012062830   146 FLSD 149 Alkaliphilus metalliredigens
WP_012159870   147 LLTN 150 Alkaliphilus oremlandii
CDB23648       151 MMSS 154 Clostridium sp. CAG:557
WP_003518407   151 ILNl 154 Hungateiclostridium thermocellum
WP_013121039   146 VItg 149 Thermincola potens
WP_006520385   146 LMAN 149 Desulfallas gibsoniae
jgi:Hore_08740 145 LMTA 148 Halothermothrix orenii H 168
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