1TLJ


Conserved Protein Domain Family
TYW3

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pfam02676: TYW3 
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Methyltransferase TYW3
The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner.
Statistics
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PSSM-Id: 396997
Aligned: 138 rows
Threshold Bit Score: 124.598
Threshold Setting Gi: 502894613
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1TLJ_A          9 LREKALNKIYHDKEIGYLDPDILGFLLAFYRnRNDVYTQSSCSGRITIV-DAEMPWDRKNsTIIFKNHLRITEQDLEDVL 87  Saccharolobus ...
Q5JES6          3 AKREALQSLFTAMRDGKVDGDIIDLLLLINS-IKGIYTTSSCSGRIGII-EEPALGAKPLsRWLIKVHRPIEFEEAKEAL 80  Thermococcus k...
Q8TZG0          3 AKREALLSLFQAIKENKVDEDIVELLLLINS-IKGVYTTSSCSGRIGII-EEPSLGAKPLsRWLIKVHRPIKFEEAKKAL 80  Pyrococcus fur...
Q5JFK6         11 QKEKAMEGLRKALEEDKVDHDIIPLLEKINA-LQNYFTTSSCSGRISVM-EMPHFGDKVNsVWLGKWHREVRLEEVLEAV 88  Thermococcus k...
Q8U1V7         10 AKKEALISLEIALRKGEVDEDIIPLLKKINS-LDNYFTTSSCSGRISVM-EMPHFGDKVNaKWLGKWHREVSLDEVLGAI 87  Pyrococcus fur...
jgi:Aboo_1247   3 NKKEALEKYERAKSKGEVDKDIISLLEKINS-LPYFYTTSSCSGRIVLL-NIPEIGDKKDaKFVCKWHREVDKKELVNCL 80  Aciduliprofund...
Q58905          6 DKKRTLMNLELAIREGLVDEEIIPILNKINE-IDNYYTTSSCIGRVGIMeIPKDKNPKLYsRWLGKWHHYASYDELFNAL 84  Methanocaldoco...
WP_011973767    5 DKKRTLNKLNEAIKNNFVDKGVMYIVDKINE-KENYYTTSSCIGRCGIMeFPKNKTPKIFsKWLGKWHHYATNEELFDAM 83  Methanococcus ...
WP_013180617    5 aKYNKMKKLQYAVDNNLVDKEIMYFVDRINE-EDEYYTTSSCIGRCGIMeFPKNVNTKIYsRWLGKWHHYATTDEMNIAI 83  Methanococcus ...
Q6M0G1          5 DKEFTLKKLQEALDNDFVDLEVMYLVDKINE-FKDYYTTSSCIGRCGIIeFPKDKNPKINsRWLGKWHHYANYDEIDEAL 83  Methanococcus ...
1TLJ_A         88 SKNQ--VRRLWLIVQGPIIHIYAKNIETGWDILKIAREAGFKHSGILATNQKGVLVELRTGIRMVHLLResntERVDKDK 165 Saccharolobus ...
Q5JES6         81 KNAK--EGIIFLKSQPPIFHVVAEDLEKARKLHELGLASGFKYTTFKVISK-RYLVEINATEYLTAPLGrdgrVLVDDGY 157 Thermococcus k...
Q8TZG0         81 KNAQ--KGLIFLKSQPPIFHVVTESLELARKIHEIGLSSGFKYTTYKVISR-RYLVEINGTEYLTVPLGkdgkVFVTDEY 157 Pyrococcus fur...
Q5JFK6         89 GKHR--SGQLWFLVRSPILHVGARTLEDAVRLLNLAIGLGFKYSNIKSVSHKKLVVEIRSTERMDVPLGengeLWVDEAY 166 Thermococcus k...
Q8U1V7         88 KKHR--SGQLWFLVRSPILHVGAKTLEDAIRLVNLAVSCGFKYSNIKSISNKKLIVEIRSTERMDVLLGengrILVGEEY 165 Pyrococcus fur...
jgi:Aboo_1247  81 KDYK--EHYLFFIMQSPIIHIVASETEWANKLIKISLECGFKYTSIKKIESKKILVEVLSTENLHIPIGregkIIVKEEQ 158 Aciduliprofund...
Q58905         85 KNKK--EGYIVFVMNSPILHIACKDIESAKKMLELAIHSGLKASSIKSISDKRVIVEILTTYKVDTPIGedgeIFVDNNY 162 Methanocaldoco...
WP_011973767   84 ANKSeeFKNIIFIMNSPILHIASKDMECAKKLLECAYHNGLKASSIKSINKRRIIVEIMTTNKVDAPIGidgkIVVDDEY 163 Methanococcus ...
WP_013180617   84 ESASpdYDRLYFVLNSPIMHIACKDAFSAKKLLEIAYHNGLKASSIKSLSEKRYIVEFLTTMKLDAPIGfdgkLVVDDNY 163 Methanococcus ...
Q6M0G1         84 LKKSenFEKISFVLNSPILHVASRNADTSKKLLELAYHNGLKASSIKSISSKRYIVEIMTTAKMDAPIAydgkMVVNREY 163 Methanococcus ...
1TLJ_A        166 IKTLVNVCNEVLARGKQKMNLLKDLLS 192 Saccharolobus solfataricus
Q5JES6        158 LRFAVEIGNEMLRRSKGRLPRLEENFR 184 Thermococcus kodakarensis KOD1
Q8TZG0        158 LEFVIEIGNQMLMRGKSRLPRLREKFE 184 Pyrococcus furiosus DSM 3638
Q5JFK6        167 IEKIVNLANAQVRRFKGKLKRLEEEIE 193 Thermococcus kodakarensis KOD1
Q8U1V7        166 LRKIVEIANAQVRRFKEKLKRLESNID 192 Pyrococcus furiosus DSM 3638
jgi:Aboo_1247 159 LTFFLEMANKLLIRAKGKLKCLEEKIN 185 Aciduliprofundum boonei T469
Q58905        163 LKFLLDYSNSKLKRAREILMRWANRLD 189 Methanocaldococcus jannaschii DSM 2661
WP_011973767  164 LKVLLKIGNEKLKLSRDGIYRFYEKLD 190 Methanococcus aeolicus
WP_013180617  164 LNILLNESNLKLMKAREMLHRVYLKFD 190 Methanococcus voltae
Q6M0G1        164 LDILLDEGNLKLKHARKSLKRFYEKLN 190 Methanococcus maripaludis
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