Conserved Protein Domain Family
PS_Dcarbxylase

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pfam02666: PS_Dcarbxylase 
Phosphatidylserine decarboxylase
This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.
Statistics
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PSSM-Id: 396989
Aligned: 107 rows
Threshold Bit Score: 73.081
Threshold Setting Gi: 501089946
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4WRM8        202 YRKLKPGvRPI-DPDPh---aIVSPSDGRILQF--GLIDR--GEVEQVKGIT-YSLDAllgaatpssadhskkfmnhmae 272 Aspergillus fu...
Q18EW4         48 LWFFRDPsRQP--SGPg----IVAPAEGRITVI---REEG---------------------------------------- 78  Haloquadratum ...
WP_007474895   46 VYFFRNPaRIPeDDSEn---aIISPSDGTIIEI--KESIS--PITNK--------------------------------- 85  Caminibacter m...
Q58227         20 VYFYRDPdRVI-TKGNn---iILSPADGTVEYI--KFYENgnPEVFKDGNCYvLNVSRyf-------------------- 73  Methanocaldoco...
O27105         36 MQFFRDPdRIP-PSDEd---lIIAPADGRRLSGkiDRIER--------VGSD-YPLIDrifp------------------ 84  Methanothermob...
jgi:Sfum_2902  21 IWFFRNPpRSV-PPGDn----LVSPADGTVVYV--EKVKEg-REVFSIKHGLvARLADitre------------------ 74  Syntrophobacte...
Q2RLA3         41 VWFYRDPvRVP-PTEAg---tILAPADGKVVYI--KPFRN--GEVVAEKLGQaIPVREimkap----------------- 95  Moorella therm...
Q9RU22         42 VYRFRDPvRLP-PADQsgagaVLSPADGLVSFV--RRIEG--GQVNG------QNVAEllgt------------------ 92  Deinococcus ra...
A0B8T2         42 IHFHRDP-ERF-PEGEg----MLSPADGRIVEA----------------------------------------------- 68  Methanothrix t...
O28234         39 AYFFRDPeRKI---GEg----VVSPADGRIDYL----------------------------------------------- 64  Archaeoglobus ...
Q4WRM8        273 psqkdaanmladeefakvngisytlptllagdkggarrraasldastkseaaaeeavkaeiargdgspwyapkptsnnAL 352 Aspergillus fu...
Q18EW4         79 ------------------------------------------------------------------------------EQ 80  Haloquadratum ...
WP_007474895   86 ------------------------------------------------------------------------------NS 87  Caminibacter m...
Q58227         74 ----------------------------------------------------------------------------pnGC 77  Methanocaldoco...
O27105         85 ---------------------------------------------------------------------------dgsGG 89  Methanothermob...
jgi:Sfum_2902  75 --------------------------------------------------------------------------dlgrNR 80  Syntrophobacte...
Q2RLA3         96 --------------------------------------------------------------------------glgdRG 101 Moorella therm...
Q9RU22         93 ---------------------------------------------------------------------------pqrDG 97  Deinococcus ra...
A0B8T2         69 ------------------------------------------------------------------------------DE 70  Methanothrix t...
O28234         65 ------------------------------------------------------------------------------EG 66  Archaeoglobus ...
Q4WRM8        353 YYVVIYLAPGDYHRFHSPVSWVVESRr-------hFA----GEly----------sVSPYLQRHLpglftlN-----ERV 406 Aspergillus fu...
Q18EW4         81 IRIGIFLNVTDVHVARAPIDGEVTQCt-------hRE----GA-------------HRPAFMKDSt----rN-----ERV 127 Haloquadratum ...
WP_007474895   88 IKISIRLSLFDVHIQRSPIKGEMSARe-------yIH----GMfl----------sLNSNKASEL------N-----EQN 135 Caminibacter m...
Q58227         78 YVVGIFMSPLDVHVNRAPIGGRIVYIk-------hID----GSfy----------pAFLEGVEKI------N-----ERN 125 Methanocaldoco...
O27105         90 ILISTFMSPFDVHVNRAPVSGKVIYTe-------hVD----GRfq----------vARSRVLTEN------------EKN 136 Methanothermob...
jgi:Sfum_2902  81 ILIGIFMSPFNVHYNRAPLSGTVESIs-------rYPss-gGNlnmramhwrtlfrIAPYYRDSRhi--iqN-----ERT 145 Syntrophobacte...
Q2RLA3        102 WIMGIYMSPLDVHFNYAPIAGRVEDMv-------hTR----ARvnlpmv--dlweyIRLTYFRRAvdlfchRyrlvnERL 168 Moorella therm...
Q9RU22         98 WLLGLYVGPLDVHFTYAPVGGTVISAgkrdgtrqgLPlaetARll----------aGQPVDLLGSaav-rgN-----ERY 161 Deinococcus ra...
A0B8T2         71 KHIYIFMGPMDVHVNRAPLDGVVRSVe-------fRG----GD-------------HSPAFRHPLk-----N-----AHS 116 Methanothrix t...
O28234         67 RRLEIFMSPFDCHINRAPWGGKVLSVk-------fIE----GS-------------TPPAFIRKSgv---rT-----NEI 114 Archaeoglobus ...
Q4WRM8        407 VLLGRwrW-G-F--FSYIP-VGATNVGSIKINfdselrtnslttdtaadraaalaaqrgeqypgfveatylhasrtlGGH 481 Aspergillus fu...
Q18EW4        128 DIAVTt-SdG----PAEISlIAGAVARRIHPYi-------------------------------------------dNGM 159 Haloquadratum ...
WP_007474895  136 RVLFE----NeKnqIVVNQ-IAGFITRRIIMFr--------------------------------------------DLG 166 Caminibacter m...
Q58227        126 IVIIK--N-G-SeyVGVVQ-IAGFVARRCWLSi-------------------------------------------kEGE 157 Methanocaldoco...
O27105        137 LIVIKt-DyG-N--VGVIQ-IAGFVARRIVQYv-------------------------------------------kEGE 168 Methanothermob...
jgi:Sfum_2902 146 VTRIDgkykGvTisCYVVQ-IAGRTVHCIESYy-------------------------------------------rEGM 181 Syntrophobacte...
Q2RLA3        169 TIFLD----GeGikIAMVE-IADKFVNKINSFi-------------------------------------------kPGQ 200 Moorella therm...
Q9RU22        162 SYAVQge-gGqTvtVGLIA-PGAGLQAITYLD---------------------------------------------EGQ 194 Deinococcus ra...
A0B8T2        117 IIEIEs-EmG-R--FTLKQ-ISGMAARRVVCWv-------------------------------------------sPGD 148 Methanothrix t...
O28234        115 LIETE--H-G----VFRVLqMAGIFARRIVSYv-------------------------------------------sEGD 144 Archaeoglobus ...
Q4WRM8        482 PLQRGEEMggfqLGSSIVLVFEapmgtrksfdigweggkreggwnwtiekgqRIKMGQKLGY 543 Aspergillus fumigatus
Q18EW4        160 SIDRAQRIghidFGSRVDVVLPpgytadd----------------llitdgqKVRAGESIVA 205 Haloquadratum walsbyi DSM 16790
WP_007474895  167 PIKLGERYgmitFGSQVDVYLPknitlk-------------------vsefqKVKAGESLIG 209 Caminibacter mediatlanticus
Q58227        158 CINMGQKIgmikLGSQTAVIIPanynit-------------------vkvgeRVYAGQTIIA 200 Methanocaldococcus jannaschii DS...
O27105        169 YVERGDRIgmirFGSRVDLVLPencevl-------------------vktgsRPMAGETVVA 211 Methanothermobacter thermautotro...
jgi:Sfum_2902 182 SVKKGDIFgmirVGSQVDVVVPcldgmrp-----------------svrigdKVRAGRTVLV 226 Syntrophobacter fumaroxidans MPOB
Q2RLA3        201 VVDRGQKVsfieRGSQVDLVIFsedvef------------------tvrvgqQVYGARTVVA 244 Moorella thermoacetica ATCC 39073
Q9RU22        195 TVRQGNKAaflaEGGLVLLALPgsvtpq-------------------vsvgeRVRGAETVVA 237 Deinococcus radiodurans
A0B8T2        149 RLRRGQRIgmirFGSGVIVTAPpgyrii-------------------arkgsRVRAGQTVIA 191 Methanothrix thermoacetophila PT
O28234        145 VVKKGQKIgmirFGSRVVLEVPegfrfv-------------------rgvgeKVKAGETVAL 187 Archaeoglobus fulgidus DSM 4304
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