3A3U,1ZBM,2NXO


Conserved Protein Domain Family
VitK2_biosynth

?
pfam02621: VitK2_biosynth 
Click on image for an interactive view with Cn3D
Menaquinone biosynthesis
This family includes two enzymes which are involved in menaquinone biosynthesis. One which catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one which may be involved in the conversion of chorismate to futalosine. These enzymes comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between the two domains may form the active site, a conserved histidine located within this pocket could be the catalytic base.
Statistics
?
PSSM-Id: 396953
Aligned: 85 rows
Threshold Bit Score: 168.882
Threshold Setting Gi: 123528679
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3A3U_A          4 LRLGFSPCPNDTFIFYALvhgrvespVPLEPVLEDVETLNRWALEGRLPLTKLSYAAYAQvrDRYVALR--SGGALGRGV 81  Thermus thermo...
jgi:Nmar_0524   2 MRLGIVDYINMLPVVYGLekn--kvkFDGKIIRDVPTNLNSSLSQGIIDVGFISSIEYAR--GDYNLLPy-CISSKKTVM 76  Nitrosopumilus...
WP_012174699    4 TRVGRIRYINVAPVYHGFdsg--qvaAPFSFISRAPATLNSMILNSALDISPVSSIAYARhhNHLMVLPdlSISCFGDVM 81  Desulfococcus ...
jgi:Sfum_3086   9 LRLGRISYLNVLPIYYPLesg--iiaHPFEIVPGTPACLNGLMADGRLDLSVVSSIEYARhpDRYFIVPdlSISCFGPVK 86  Syntrophobacte...
Q314P9         11 LRIGRISYLNVLPIYHSLekd--aagSGYELVYGPPAELNRLMAAGELDVASTSSIEYARnaQQYYLVPdlAIGSCGPVM 88  Desulfovibrio ...
Q39WZ6          3 LTIGHIEYSNCTPIFTALqrs--mdcSGYSFVRGVPAHLNRLLAMGEIDVCPSSSIEYGKypDRYLVLPdlSISAVGPVK 80  Geobacter meta...
Q74BM4          3 LTLGHIVYANCTPIFTALrdl--ghsPDYRIVTGVPAQLNRLLAHGEIDVCPSSSIEYAThpDRYVILPdlSISAVGPVK 80  Geobacter sulf...
jgi:Gura_1828   3 LRIGQIDYANCTPIFTALksn--fdcTDYCFVSGVPSTLNAMLATGEIDLCPSSSIEYGKasEKYCLLPdiSISSIGAVK 80  Geobacter uran...
ACH38582        3 IDIGHIKYANCTPIFTALash--fdcSGYRFVDGVPADLNAMLRSGEIDLSPSSSIEYATahEQYCLLPslSISSIGAVK 80  Geobacter bemi...
jgi:Ppro_2019   2 LRIGRIEYANCTPLFHALnal--fpeNDYRYVGGVPAYLNGMLASGGIDVCPSSSITFAThsDQYLIIPdiSISSSGPVL 79  Pelobacter pro...
3A3U_A         82 GPLVVArg----pLqaleglRVAVPGRHTTAYFLLSLYAQGF-----VPVEVRyDRILPMVAQGevEAGLIIHESRFtyp 152 Thermus thermo...
jgi:Nmar_0524  77 SVVLVSkvpfeeiK------SIQLSTEAATSVILLKILMRYAykqkvSYGKNG-------------DAELLIGDQALkkl 137 Nitrosopumilus...
WP_012174699   82 SVVLASrfpidqlDg----kTIVFSSESETAVGFLRLYFAQKki-apVFVATQiNSPEDRVCADa-AGVLTIGDLALtge 155 Desulfococcus ...
jgi:Sfum_3086  87 SVLLLSrrpwtelEg----eSILVSSQSHTSIALLRILFAFQhgmhvRLVPGD-CTEALARRDSp-AAFLAIGDEALrlk 160 Syntrophobacte...
Q314P9         89 SVILLSrqpvetlEg----qTILTTSQSHTSAALLRLIMRYHyglnvTYRTGS-ASEQIQSHNPp-QALLAIGDEALrlr 162 Desulfovibrio ...
Q39WZ6         81 SVLLFSrvplerlDg----aVIGMTTESDTSVNLLRIILTTFqgftnSFERTP--LPLAEALDSy-PALLLIGDRALkga 153 Geobacter meta...
Q74BM4         81 SVMLFSrvpieqlDg----aTIAMTTESDTSVNLLKIILGLFhrftnRFQRTD--LPLTEALEAh-PGLLLIGDKALrga 153 Geobacter sulf...
jgi:Gura_1828  81 SVFLFSrvpiedlDn----kTVGLTTESDTSVNLLKIILAKKhghtnHFQRTS--LPLAEALKSf-SALLLIGDAALkta 153 Geobacter uran...
ACH38582       81 SVFLFSsvpveelDg----cPIGLSAESDTSVNLLKVLLARKygfsnSFERTR--EPLAEALKRf-PGLLLIGDAALkga 153 Geobacter bemi...
jgi:Ppro_2019  80 SVLLFSktpiedlDg----aQVLLSSESATSVNLLKILLRIRyncqcTFQITD--QSTPGAMGGn-EAILLIGDAALrat 152 Pelobacter pro...
3A3U_A        153 r-yglVQVVDLGAWWEERTGLPLPLGAILARRDlg----eGLIRALDEAVRRSVAYALAHPEEALDYMRAHAQELsdevi 227 Thermus thermo...
jgi:Nmar_0524 138 i-kkpKHVLDLGKAWNTFSNKNMVFGVLASRKNlp----qKKIETLLDSIHLSYQWGQDNLNEIIDYAAEKTNLD----- 207 Nitrosopumilus...
WP_012174699  156 werrfDHVWDIGRLWQELAGRPFVFGLWVVRRAfae-arpEVVAEILKRFHASKQKGLAQIDQVIVRAAGVTGLD----- 229 Desulfococcus ...
jgi:Sfum_3086 161 tvegyPYCCDLGEAWTRWTGLPFVFALWVVQRNavd-kgaGEIPVGMGALAAAKQWGCSHLDTICAEALRKGILR----- 234 Syntrophobacte...
Q314P9        163 nhpmyPYRVDLGEAWRRWTGLPFIFGVWVVSRDsvaagrfDTDPCAL--LQGGRDWGAQHMDTILDLAARHDFLS----- 235 Desulfovibrio ...
Q39WZ6        154 ltgggYHIYDLGDLWYRATGLPFVFALWLLRREaae-nkpHEVARLAVDVARAKRIAYDSYPEIAAQAPEREWID----- 227 Geobacter meta...
Q74BM4        154 lagtaPHVYDLGELWYRFTGLPFVFALWLVRREaae-sqrDKVVRLGADLLKAKRISYESYPAIAAEAPERNWIG----- 227 Geobacter sulf...
jgi:Gura_1828 154 mthhgLYVYDLGELWHDFTGLPFVFALWIVRRDaaa-ekhAEIKALSGKLKAAKQLAYDSYESIASDCSEREWMG----- 227 Geobacter uran...
ACH38582      154 asgvaAYCYDLGQLWYDFTGLPFVFALWIVRRDaat-akhAGMTMLARDLVAAKELAYRSYPEIAASCQEREWIG----- 227 Geobacter bemi...
jgi:Ppro_2019 153 msrhdMFVYDLGELWYRWTGTPFVFALWLTTREvag-rrgDELMRLARQLGHAKQYAEEHLEEIVRVSPERDWMG----- 226 Pelobacter pro...
3A3U_A        228 WAHVHTYVN-AFSLDVgEEGERAVARLFAEAEA 259 Thermus thermophilus HB8
jgi:Nmar_0524 208 KKIISQYFA-GLSYSIgIKEISSLKEFYTYSKK 239 Nitrosopumilus maritimus SCM1
WP_012174699  230 VETCRRYYR-LLQYDLgPEQIAGAETFFDMLFA 261 Desulfococcus oleovorans
jgi:Sfum_3086 235 KEELEEYYR-MLGYNLdGNEQSGLERFFGYLPQ 266 Syntrophobacter fumaroxidans MPOB
Q314P9        236 RDELVEYFR-GLVYTMgEEAQKGLRTFYSKLVE 267 Desulfovibrio alaskensis G20
Q39WZ6        228 SAVLVDYWR-TISYDLtPAHLKGVRLFYNYAAS 259 Geobacter metallireducens GS-15
Q74BM4        228 EEQLVDYWR-TISYDLtPAHLDGLRLFFRHAAE 259 Geobacter sulfurreducens
jgi:Gura_1828 228 TEALVDYWR-TISYDLtPEHCAGLQRFFRYAAE 259 Geobacter uraniireducens Rf4
ACH38582      228 ESDLVDYWN-TINYELtEAHIEGARLFFRHAFE 259 Geobacter bemidjiensis Bem
jgi:Ppro_2019 227 PELLLDYWRnNISYDLtDLHLSGLKRYFRFAAE 259 Pelobacter propionicus DSM 2379
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap