3WHP


Conserved Protein Domain Family
B12-binding_2

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pfam02607: B12-binding_2 
B12 binding domain
This B12 binding domain is found in methionine synthase EC:2.1.1.13, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of pfam02310. The structure of this domain is known, it is a 4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif.
Statistics
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PSSM-Id: 396942
Aligned: 720 rows
Threshold Bit Score: 28.9741
Threshold Setting Gi: 81714709
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WHP_A                  92 LLEALLRGDLAGAEALFRRGLrfwG----PEGVLEHLLLPVLREV----GEAWHRGEIGVAEEHLASTFLRARLQEL 160
Q88E38                 102 IRLAVQHFDVASLNRLYDEVF---Aas-tLDQVFADVFMPVWHDMvvrqGGYGQASEWLFYDQFLRGRVFArlqlar 174 Pseudomo...
Q28UL7                  67 LAQALVDTDRARVDEMIADLL---GsdlgVRDLCLDHLAPAARVL----GAFWERDQLQFADVSLATARIQAIVRtm 136 Jannasch...
WP_025311820            69 LACALCDIDDESAELIVADMI---AagvsVEEVCIDHLAAAARHL----GDLWESDRLPFMDVTLATARIQQIMRkm 138 Roseibac...
PRJNA210423:M911_08240  56 FSRMVIEHDAAAALAYVETLR---TqgtaLESVFVHLLAPTAKRL----GELWEEDQADFTEVTVGLCRLQHVLREl 125 Ectothio...
Q6A566                  81 FAELVLDADDDRAVACIQAHR---DhgetLERIYLDLLVPTANHL----RHLWADDERDFADVTLALWRLQQLLRHf 150 Bradyrhi...
WP_013418678            20 FTSLLLSPDGAGAAAFVDRTR---RegheVEAILLDLFGPAAVRL----GHLWESDRCGFAQVTIAASRLRELLRTr 89  Rhodomic...
Q21CP9                 132 LARLLLSPQPDDALALLDQSF---AleksPSQLFTSLFEPAARCL----GDLWSADHCSEFEVTIALCHLQSAMRRI 201 Rhodopse...
Q39S05                  22 VLRRINDADRDGASRLVDQWA---Avh-gYGDAIAEILEPVLRTV----GDRWEREAISLAQGFVAGKVAEDILNKa 90  Geobacte...
BAM02464                31 FYTALISGDRAAAGEVLAECR---SgkatAEALANHLIWPTLDQV----QKAHRNDQLSDLSYHFATRLMRSITDRL 100 Phycisph...
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