Conserved Protein Domain Family
CsrA

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pfam02599: CsrA 
Global regulator protein family
This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.
Statistics
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PSSM-Id: 396934
Aligned: 256 rows
Threshold Bit Score: 42.3646
Threshold Setting Gi: 503716759
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013112520         1 MLVLSRRPHESIRLTipenlpPgtVIEITTLEVRANAVRIGLTAPRSVQIARSELVDE 58  Planctopirus limnophila
CDE69919            17 MLKLSLKQGQYINIG------D--NIRVVYVGGSGGHGRLMIDAPKDIPIVRSNIEEn 66  Clostridium sp. CAG:277
CCY29183             1 MLKISLKQGQYVNIG------D--NIRVVYVGGTGNHGRLMIDAPKDVRIARSTVEQn 50  Roseburia inulinivorans CAG:15
wucgs:EUBELI_00423  12 MLKLTIKPGEFINIG------N--DIRVVYSGGTDGNIHLLIDAPRELNIVRSKVLSR 61  [Eubacterium] eligens ATCC 27750
WP_118676545         1 MLRLTVSPEEYLMIG------D--NIKIVFLGGSKNHLQIMVDAPRDVDIMRSEVYER 50  unclassified Clostridium
CCZ90698             1 MLRLSVSTEEYLLIG------D--NIKIAFLGGSHNHMRIMIDAPKEVNIIRSSVLEK 50  Clostridium sp. CAG:167
CDE55753             1 MLRLTVGIEDYIQIN------E--DIKIIFLGGSQKNMRVMIDAPKEVKIARGKAIKK 50  Roseburia sp. CAG:303
CDF44310             1 MLRLSVQKNEYIMVG------K--DVKITFLGGVKNQAHIMIDAPKEVNIARGRAIEk 50  Roseburia sp. CAG:100
CDD34699             1 MLRLTLSTEEYLMLG------D--DIKIVFLGGSNNHLRIMVDAPKEVDIVRSKVLEK 50  Roseburia sp. CAG:309
WP_117568817         1 MLRLTVSPEEYLMIN------D--NIKIVFLGGTKNHLRIMIDAPKEVNIVRSTVLEN 50  Clostridium sp. AF46-9NS
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