4RG1


Conserved Protein Domain Family
Methyltrn_RNA_3

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pfam02598: Methyltrn_RNA_3 
Putative RNA methyltransferase
This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA, and may function as a methyltransferase.
Statistics
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PSSM-Id: 396933
Aligned: 156 rows
Threshold Bit Score: 180.047
Threshold Setting Gi: 388525550
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RG1_A            12 LSVALPGSILDNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGqdaktvegeftgvgkkgqACVQLARILQYLECPQY 91 
jgi:Hmuk_1827      3 TSVLVPSSLVREAEDRREATRKLGYVARAAVVFRVDRLTIFPDPAgag-------------kwEDGFVETVLRYAATPPY 69  Halomicrobi...
KHU:HacjB3_05025   3 VSILVPSSVVREAEDKREATRKLGYVARAATVFRADRLIVFPDRDger-------------rwGGGFVEAVLRYAATPPY 69  Halalkalico...
WP_004042620       3 LSVLVPSSLVREAEDQREATRKLGYVARAAAVFRANELVVFPDEDgen-------------nwGGEFVETVLRYAATPPY 69  Haloferax v...
ELY30721           3 LSVLVPSSLVREAEDKREATRKLGYVARAATVFRADRLIVFPDREger-------------rwGRKFVETVLRYAVTPPY 69  Halogeometr...
Q18GE8             3 LSVLIPSSVVREAEDKREATRKLGYIARSATVFRVDHLIVFPDRGger-------------rlGGEFVETVLRYAATPPH 69  Haloquadrat...
WP_049953222       3 TSVLVPSSLAREAEDKREATRKLGYVARAATIYRADRLIVYPDRDget------------gklGGGFVHTVLRYATTPPH 70  Halostagnic...
WP_013878569       3 VSVLVPSSLTREAEDKREATRKLGYVARAATIFRADRLVVYPDRDget------------grfDGGFVSTVLRYAATPPY 70  Halopiger x...
WP_015322643       3 ASVLVPSSLTREAEDKREATRKLGYVARAATVFRADRLVVFPDREger------------grfDGEFVDTVLRYATTPPY 70  Natronococc...
ELY33855           3 VSVLVPSSLTREAEDKREATRKLGYVARAATIFRVDRLIVYPDRDgdt------------grfGDEFVSTVLRYAATPPY 70  Natrialba m...
4RG1_A            92 LRKAFFPKHQDLQFAGLLNPLDsphhM-----RQDE-ESEFREGIVVDRpTrpGhGsFVNCGmKKEVkIDK----NL-EP 160
jgi:Hmuk_1827     70 LRKEVWGKRDELEYVGVLPPLR----VrsqtgSGSEgSGSLRQGIVTEVgAdgR-V-RVNCGlQHPIsLPVpsamEVpGE 143 Halomicrobi...
KHU:HacjB3_05025  70 LRTEVWGMRDELEYVGVLPPLR----AvsrtgSGSNgSGSLRQGLVTEVgPegR-V-RVNCGlQHPLsLITppgmEV-QQ 142 Halalkalico...
WP_004042620      70 LRKEVWGKRDELRYAGILPPVL----VasttaDDSDeSPALREGIVTEVgPddR-V-RVNCGmQHPIsLFVppgmDL-TE 142 Haloferax v...
ELY30721          70 LRKEVWGHRDELEYVGVLPPLL----VssttgSESDdSGSLQQGIVTEVgPdgR-V-RVNCGmQHPIsLYTpsdmMV-KE 142 Halogeometr...
Q18GE8            70 LRKKIWGRRDELEYVGVLPPLR----VssttgSESTdSGSLTQGIVTEVgPddR-V-RVNCElQHPVsLHVpesvSV-RE 142 Haloquadrat...
WP_049953222      71 LRKEIWGKRDELEYVGVLPPLR----AtsqtgSESDdSGSKRQGIVTEVgPdqR-V-RVNCGlQHPIsLNVpsemAL-AE 143 Halostagnic...
WP_013878569      71 LRNEAWGMRDELEYAGVLPPLR----AvsqtgSESNdSGSLRQGIVTEVgPegR-V-RVNCGlQHPIsLNTppdmEV-DE 143 Halopiger x...
WP_015322643      71 LRNEVWGMRDELEYAGILPPLR----AvsrtgSESNdSGSSRQGIVTEVgPdqR-V-RVNCGlQHPIsLNVppsmEL-EE 143 Natronococc...
ELY33855          71 LRNEAWGMRDELEYVGVLPPLR----AtsqtgSESDgSGSLRQGIVTEVgPdqR-V-RVNCGlQHPIsLNVppkmAV-SV 143 Natrialba m...
4RG1_A           161 GLRVTVRLnqqqhpDcktyhGKVVSSQDPrtkaglywGYTVRLAsCLSAVFAEApfqdGYDLTIGTSergsdVASAQLPN 240
jgi:Hmuk_1827    144 GERVTVRVssrrpvR-----AKLVDEPLT--------GYVVDTA-DVDTALERS----DAGFAIAASrhgeeLGVDRLGQ 205 Halomicrobi...
KHU:HacjB3_05025 143 GERVTVRIssrrpvR-----AKLTEEP-A--------GLEVERT-DLPAALGRP----DAGVRIATSrfgeeLTTGRLPG 203 Halalkalico...
WP_004042620     143 GERVAVRIssrepvR-----ARIVDEPLP--------GFDVSRM-DLTEALGRP----DAGVRIATSrygepLSVPTLGD 204 Haloferax v...
ELY30721         143 GERVAIRIssrepvR-----ARIVDEPVP--------GFDVSRM-DLEEALGRA----DAGITIATSrfgesLTVPKLAD 204 Halogeometr...
Q18GE8           143 GTRVAIRIssrepvR-----ARIVDTPLS--------GFDVSCL-DLVDALEHA----AAGITVATSrhgdtVTTGRLPE 204 Haloquadrat...
WP_049953222     144 GERVTVRIssrrpvR-----AKIVDKPTQ--------GLSIEQT-DLSAALSRE----DAGVRIAASrfgepLTVGKLET 205 Halostagnic...
WP_013878569     144 GERVTVRIssrrpvR-----AKLVDEPLP--------GLSVEQT-DLSAALSRE----DAGVRIAASrhgerLTVGRLET 205 Halopiger x...
WP_015322643     144 GERVTVRIssrrpvR-----AKLVDDSLP--------GIDVEWT-DLEAALGRE----DAGVRIAASrfgaeLTVGRLGT 205 Natronococc...
ELY33855         144 GERVTIRIssrrpvR-----AKLVDEPLP--------GLTVERT-DLQAALSRE----DAGVRIAASrfgaeLTVGRLGT 205 Natrialba m...
4RG1_A           241 F----------RHALVVFGG-LQGLEAGAdadpnleVAEPSVL------------------------------------- 272
jgi:Hmuk_1827    206 Lverr---ddaGHMTVAFGApERGLPAIF-------GLDPDDAvpdgtg------------------------------- 244 Halomicrobi...
KHU:HacjB3_05025 204 Lsar----ieaDGTTVAFGSpGRGLPDIL-------DVNAEAVgdqpadgve-------------------------pgs 247 Halalkalico...
WP_004042620     205 Ltari---tdaGGMTVVFGSpGRGLPDML-------GMPPEDVadvep-------------------------------- 242 Haloferax v...
ELY30721         205 Lspr----ierEGATVVFGSpGRGLPDIL-------GIDAEEVtveps-------------------------------- 241 Halogeometr...
Q18GE8           205 Laar----vnrAGATIAFGApGRGLPVIL-------GDDNAPDsqtqtdektvspanvdt--------tgdntasevvep 265 Haloquadrat...
WP_049953222     206 Lagr----lerDGLTVAFGApERGLPAIL-------GIDADAVqkdgvarldaad-------------------dadvep 255 Halostagnic...
WP_013878569     206 Lagr----idrDGLTVAFGApERGLPAIL-------GIEASDVaaayggdaddg--------------------nvepta 254 Halopiger x...
WP_015322643     206 Lagr----rerDGMTVAFGApERGLPAIL-------GMDEETVdalsrwdgvdg---------------------ggvep 253 Natronococc...
ELY33855         206 LaghterdttrDGFTIAFGApERGLPAIL-------ELEDTTVeslsawpswlaededgveptsavgdddtvaaetdada 278 Natrialba m...
4RG1_A           273 -----FDLYVNTcpgqgSRTIRTEEAILISLAAL 301
jgi:Hmuk_1827    245 dddagFDLWLNTvpnqgSEVVRTEEAMFATLASL 278 Halomicrobium mukohataei DSM 12286
KHU:HacjB3_05025 248 dgserFDLWLNTiphqgSETVRTEEAMFASLACL 281 Halalkalicoccus jeotgali B3
WP_004042620     243 svgpgFDLWLNTiprqgSEVVRTEEAMFASLASL 276 Haloferax volcanii
ELY30721         242 -dgpgFDLWLNTiprqgSEVVRTEEAMFASLASL 274 Halogeometricum borinquense DSM 11551
Q18GE8           266 nvdpgFDLWLNTipqqgSEVVRTEEAMFASLALL 299 Haloquadratum walsbyi DSM 16790
WP_049953222     256 ngdpgFDLWLNTvpnqgSDVVRTEEALFATLASL 289 Halostagnicola larsenii
WP_013878569     255 dpgpgFDLWLNTvpdqgSEVVRTEEALFATLAPL 288 Halopiger xanaduensis
WP_015322643     254 tsdpgFDLWLNTvpdqgSDVVRTEEALFATLASL 287 Natronococcus occultus
ELY33855         279 adpggFDLWLNTvpdqgSDVVRTEEALFATLAPL 312 Natrialba magadii ATCC 43099
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