5KO9,6OE7,6KCQ,2BDV


Conserved Protein Domain Family
SRAP

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pfam02586: SRAP 
SOS response associated peptidase (SRAP)
The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.
Statistics
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PSSM-Id: 396923
Aligned: 436 rows
Threshold Bit Score: 142.278
Threshold Setting Gi: 123500124
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KO9_A           1 MCGRTSC-H-L-------P---RDVLTRACAyQDRrgqqrlpewrD-PDKYCPS--YNKSPQSNSPVLLs-rLHFEkdad 64 
WP_012683765     1 MCGRFVKkGlKydadgnpEiggFNDIRIIYR--GQ-------------GMLRER--YNIAPASQISVLR---TTDeg--- 57  Gemmatimonas ...
WP_012091585     1 MCGRFTQ-T-Y-------T---WAEIHAMYN-LVP----------AtPRNLQPR--YNIAPTTQIGVVTq-aGND----- 49  Ochrobactrum ...
CCD32126         1 MCGRFTQ-R-L-------S---WEELHRLAD-LIG----------Q-PRNLAPR--YNIAPTTQIEVLWpaeAGG----- 49  Methylocystis...
CCJ08336         1 MCGRFTQ-H-L-------S---WEELQRLAD-LIG----------Q-PRNLQPR--YNVAPTTMIEVIRptpA-G----- 48  Methylocystis...
WP_015481161     1 MCVHTSL-T-K-------S---AKAIEKKTKkEFT----------T-PQLFQPYfhFNGWESKNLAITTq-eAST----- 51  Polaribacter ...
kribb:DDD_1166   1 MCGRATI-I-T-------P---AVELEKRFN-AAF----------AkGAVLQEN--VNISAGNKIPVITs-aQPN----- 49  Nonlabens dok...
WP_014264679     1 MCGRYYN-K-R-------K---KQKIAEKLQ-ASK----------VfADPLPPN--YNIAPSTFQPIVRq--ERDss--- 50  Granulicella ...
WP_015896645     1 MCGRYRR-R-S-------D---KQRIAEAFDlGMG----------LeEVFFEPE--DDIAPGSVQPVVLq-gQDGM---- 51  Acidobacteriu...
WP_012876048     1 MCGRFGL-E-A-------D---PEQLAHRFG-ATQ----------S-EIPWAPR--YNIAPSQEVPVVT----PE----- 45  Thermobaculum...
5KO9_A          65 sseRIIAPMRWGLVP-------SWFKESdpsKLq----FNTTNCRSDT---------------VMEKRSFKVPLGKgRRC 118
WP_012683765    58 ---vVADDALWWLLPpfvtdakDWMKK-----------AATFNARSET---------------IATAPSFRSAWKRgKRC 108 Gemmatimonas ...
WP_012091585    50 ---LTYSEMRWSLVP-------SWFKDSi--KKa----PFGHNARAEG---------------VATSGMFKVPLQR-QRC 97  Ochrobactrum ...
CCD32126        50 ---NELVQMRWGLVP-------GWWKKPl--KDl----PATFNARAET---------------VAEKPMFRTAFKT-RRC 97  Methylocystis...
CCJ08336        49 ---HELVQMRWGFAP-------SWWKKPl--RDl----PATFNARAET---------------IAEKPMFRSAFAA-RRC 96  Methylocystis...
WP_015481161    52 ----QIAFAKWGVLP-------THYDVSy--RTdflakTNTLNATRER---------------LFESDLYSQFIEG-QRC 102 Polaribacter ...
kribb:DDD_1166  50 ----HIQMFILGYTP-------HWAHKQ----------TYMINARSEGslnpensttykgamgIFNKPMFRHAIKS-QRC 107 Nonlabens dok...
WP_014264679    51 --eREMVLARWGLVP-------FSARSL---ADfk--gFSTFNAKAET---------------LSNSPTWKAPLKS-RRC 100 Granulicella ...
WP_015896645    52 ---RTLEMMRWGFKL-------Qd--------------RLLFNARSEG---------------IDHSKFWKESFLE-RRC 91  Acidobacteriu...
WP_012876048    46 ---KELALVRWGYSP-------QWMQEQ---SPs----RQIINAKAET---------------LFTSKTFRDAAVH-DRV 92  Thermobaculum...
5KO9_A         119 VVLADGFYEWQ----RcqGT-NQ-R-QPYFIY-FpqikteksgsigaadspenwekvWDNwRLLTMAGIFDCWe-pPEGg 189
WP_012683765   109 LIPADALYEWQ----K--VG-TA-K-KPHAIL-R-----------------------RDR-APFAFAGIFE------DG- 147 Gemmatimonas ...
WP_012091585    98 LIPATGFFEWT----G--QK-GD-K-LPWFIS-A-----------------------KDG-RPLTFAGIYDRWrdrETG- 142 Ochrobactrum ...
CCD32126        98 IIPASGFCEWT----G--KA-GA-K-TPHYFS-A-----------------------RSG-EPLAFAALWEQAk--HSGt 141 Methylocystis...
CCJ08336        97 IIPASGLYEW-----T--GA-KGaR-TPHYFT-A-----------------------RDG-RPLAFAGVCESCr--DVEs 140 Methylocystis...
WP_015481161   103 IIYADGFFEPh---eA--AGvQK-K-IPYFFK-E-----------------------KNH-ELFAFAGIYSKVienNST- 149 Polaribacter ...
kribb:DDD_1166 108 LVLVDAFIEGP----K--QE-KL-N-KPYLVYpN-----------------------RDR-GPFALAGIHDTWqhpLTG- 153 Nonlabens dok...
WP_014264679   101 LVPADGFYEWKaldsS--RK-PK-K-QPYAIS-L-----------------------TDD-EPMAFAGLWDAWk-ePKSs 149 Granulicella ...
WP_015896645    92 LVPADSFFEWK----K--VA-RS-KkPKYEFA-I-----------------------ENR-HPFGMAGLWAPWknpKTG- 137 Acidobacteriu...
WP_012876048    93 IVPCSYYFEWD----------RT-K-RPYLFR-L-----------------------RQA-EIFGLAGVRLe----QDG- 130 Thermobaculum...
5KO9_A         190 -----DVLYSYTIITVDSCKGLSDI-HH--------RMPAILDgEEAVSKWL-DFgEVSTQE--ALKLI-HPTe--NITF 249
WP_012683765   148 -----SAGLSATIITLEPNALFAPL-HN--------RMAMILP-PEDYAAWL-SP-DTDPDQ--AMALI-RKWdpgEFKA 207 Gemmatimonas ...
WP_012091585   143 -----DEITSCAIITCDANSFMRGI-HT--------RMPVILQ-EKNWREWLaEP---------RIDLL-KPApgdDLQA 197 Ochrobactrum ...
CCD32126       142 ----gEPFTSTTIIVGAANNWMNRF-HD--------RQPVILD-WRDANAWMr---GDDPGA--LLR---APPe-dSLNE 198 Methylocystis...
CCJ08336       141 ----dKKIESATIIVGPANGWMRRF-HD--------RMPVILD-WRDVSAWM-SG-----ED--PGALL-RAPpeeALQE 197 Methylocystis...
WP_015481161   150 -------TYAASIITTEANDFFKAI-HNkpnalgsyRMPLILD-PSTYETWL-MA--TTTAE--VKTVL-DSFtqqELVS 214 Polaribacter ...
kribb:DDD_1166 154 -----ELHHTVAIITSAANRLTERIeHH--------RAPVVLS-RADEEKWL-NP-DISVQE--LTRMM-QPFdskGFNA 214 Nonlabens dok...
WP_014264679   150 pqtvdTWLQSFSIITTEANELMSQV-HT--------RMPVILS-QRDWAEWL-DR---DGLRppPLHLL-KPYdsdAMQL 214 Granulicella ...
WP_015896645   138 -----RWESTFAILTGEAGPAMQPV-HD--------REPLIVA-PRDYGKYL-AP---DPRP--PLHLLrQDQd------ 190 Acidobacteriu...
WP_012876048   131 -------ESRVVIVTTEPNRVAARV-HA--------RMPAVLR-PEDEELWL-SAdETDPHR--LGRLL-LPVpddWLEY 189 Thermobaculum...
5KO9_A         250 HAVSSVVNNS 259
WP_012683765   208 YEVSKHVSNA 217 Gemmatimonas aurantiaca
WP_012091585   198 WRVSTNVNSS 207 Ochrobactrum anthropi
CCD32126       199 WIVSTRVNKA 208 Methylocystis sp. SC2
CCJ08336       198 WIVSPRVNRS 207 Methylocystis sp. SC2
WP_015481161   215 YAVSTDVFSS 224 Polaribacter sp. MED152
kribb:DDD_1166 215 YPISQKIKKP 224 Nonlabens dokdonensis DSW-6
WP_014264679   215 GPCNSAVGNV 224 Granulicella mallensis
WP_015896645   191 ePLVSQLVTA 200 Acidobacterium capsulatum
WP_012876048   190 YPVSRHVNNP 199 Thermobaculum terrenum
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