5FMN


Conserved Protein Domain Family
Trns_repr_metal

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pfam02583: Trns_repr_metal 
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Metal-sensitive transcriptional repressor
This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression.
Statistics
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PSSM-Id: 396921
Aligned: 617 rows
Threshold Bit Score: 54.3708
Threshold Setting Gi: 430785495
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FMN_B              25 SLQKLVNRLSRIEGHIRGVKTMVQENRPCPEVLIQVAAVRGALDRVARLILDDHMNECIt-------RAAaegnieQELA 97  Synechocy...
Q2G1R8               3 YDKKMINRINRIQGQLNGIIKMMEEGKDCKDVITQISASKSSLQRLMGIIISENLIECVkaaaddeeSSQ------ELIN 76  Staphyloc...
Q5HKB5               3 YNKKMINRIHRIQGQLNGVIKMMEEEKNCKDVISQLSASKSSIQRLMGIIISENLVECVkmseenseDSQ------ALIN 76  Staphyloc...
ADC50741             3 YSQDMKNRLKRIEGQVRGILRLMEEEKDCKNVITQMSAVKSATDRAMAYIIAKNMQQCIidevekgeQAD------QVVE 76  Bacillus ...
sklacau:PSAB_09720   3 YDNAIKNRLKRIEGQVRGVLAMLEEGKDCRDIVTQLTAIRTAVDRTIGSVIGSNLEHCIqeelnkghSPD------KVIK 76  Paenibaci...
WP_008339346         3 YNDQMKNRLKRIEGQVRGVIGMMEQGKSCKEVVNQLTAIRTAVDRVIMYVVGENMEQCIreelagkgSAE------HVIQ 76  Alicyclob...
WP_013074385         3 YTDAMKNRLKRIEGQVRGIMGMMEKEQSCRDVVTQLSAVRAAIDRLIVYVIGSNMEMCIrdevengrPAD------QVIQ 76  Kyrpidia
WP_013310304         5 ySDELKTRLRRIEGQVRGVLRLMDEGKSCKDVVSQLSAVRNASDKAIAQIVAENLQRCIleeqeaggDTD------KLVK 78  Paenibaci...
WP_013915060         4 YDEKVCQRLKRMEGQIRGVLKMMEEGKECKDVIAQLSAVRSAADKAMAYIVAVNLEQCIleekekgnDTG------KMVR 77  Paenibaci...
WP_015256540         5 YDEDVKRRLRRVEGQVRGVLKMMEEEKNCKDVVSQLSAVRSAVDKAIAYIVAVNLEQCIleekeagkDTG------KLVQ 78  Paenibaci...
5FMN_B              98 ELKEALDR 105 Synechocystis sp. PCC 6803
Q2G1R8              77 EAVNLLVK 84  Staphylococcus aureus subsp. aureus NCTC 8325
Q5HKB5              77 EAVELLIk 84  Staphylococcus epidermidis RP62A
ADC50741            77 EAIQLLVK 84  Bacillus pseudofirmus OF4
sklacau:PSAB_09720  77 EAVELLVK 84  Paenibacillus sabinae T27
WP_008339346        77 EAIELLMK 84  Alicyclobacillus
WP_013074385        77 EAIELLMK 84  Kyrpidia
WP_013310304        79 EAIQLLVK 86  Paenibacillus
WP_013915060        78 EAVELLVK 85  Paenibacillus mucilaginosus
WP_015256540        79 EAVELLIk 86  Paenibacillaceae
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