1JKE,3LMU,2DBO


Conserved Protein Domain Family
Tyr_Deacylase

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pfam02580: Tyr_Deacylase 
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D-Tyr-tRNA(Tyr) deacylase
This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells.
Statistics
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PSSM-Id: 396918
Aligned: 849 rows
Threshold Bit Score: 77.3941
Threshold Setting Gi: 75031183
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1JKE_C         3 ALIQRVTRASVTVegEvtg----------eiGAGLLVLLGVEKDDDEQKANRLCERVLGYRIFSdAEGKMNLNVQQAgGS 72  Escherichia coli
XP_002996706   3 IIFQKVKYAICKNe-Qkiy---------sviGCGIVIYLGISKHDTEETVDNLVNKLLKIKINDr----WTKTISEAnGD 68  Nosema ceranae ...
XP_002413647   5 VVVQQCLKARLAVaenn----------cveiGRGIVLFVSFLENATRDDVLRTAKSVLNVKLCDsGEGALVSVL-ELpGD 73  black-legged tick
7_pfamImport   2 TVLQQCLHARLQV--RpagehseaefvqvrmDRGTVLYICFFKGATDDILPKMGTPVHQVQPSQ--QGP------ERhGD 71 
Q4SCI4        12 TVLQQCLRARLQV--Rpagerse--aefvqmDRGTVLYICFFKGATDDILPKMVSTLLNLRLCEaDSGKLSSLL-ELpGS 86  spotted green p...
XP_005455994  12 TVLQQCLQARLQV--Kpadehse--aqfvqiERGMVIYVCFFKGATDDILPKMVSTLLNLRLSEsASGKMVSVL-DLpGS 86  Nile tilapia
XP_005814469  11 TVLQQCLHARLQV--Qeadeqle--aqyaqiNRGMVIYVCFFKGATDDILPKMVSTLLNLRLCElPSGKRVSVL-ELpGS 85  southern platyfish
XP_007255146 718 TVIQQCSHALLQVkpQiadads----ewveiHEGMVIYVCFYKGATKNIVPKMVNTLLNAKIFPv-SGGRNISVLELpGN 792 Mexican tetra
5_pfamImport   2 TVIQQCTAARVKI--Rpaldgaa--aqwaeiQEGMVVYVCFLHGATEDVAHQMAGSLMTTRLFRkDSGHSVSVL-DLpGS 76 
CAF97517      12 TVLQQRLHARLQV--Rpargalr--rlslsrSVMARKRKGGGPPPPPPP--PTVSTLLNLRLCEaDSGKLSSLL-ELpGS 84  spotted green p...
1JKE_C        73 VLVV-SQFTL-------AADtER--GMRPSFSKGASP-----DRAEALYDYFVERCRQ--Q------------EmnTQTG 123 Escherichia coli
XP_002996706  69 ILLI-FQETL-------SDTsLTafYEKNNFL---EI-----SRLNEIFDLFFTKLKNnyKl----------gI--IKKL 120 Nosema ceranae ...
XP_002413647  74 VLVV-PQACL-------AGK-RK--GNRVQYHGLVSK-----DTGQEFYRIFVEQCQIlmSerqwcg-gktitI--VRSG 134 black-legged tick
7_pfamImport  72 ALQLgPEPELrkqepeqDGR-VR--GREPDQHAPEQEkkehsQKGEQLCQRGSKTLRNiiAeaak-----agpT--VRHG 141
Q4SCI4        87 LLIV-PQATL-------GGE-AK--GRDVQYHTDISK-----EDGLRLHSAFVSLCEQevAka--------gpT--VRHG 140 spotted green p...
XP_005455994  87 LLIV-PQATL-------GGK-AK--GRGMQYHNNISK-----EDGLRLYSAFVALCEKelNaavae--ssaevT--VKHG 146 Nile tilapia
XP_005814469  86 LLIV-PQATL-------GGK-AK--GKGMQYHNNISK-----EDGLKLYSSFISLCEKelMtaagetgreaevT--VRHG 147 southern platyfish
XP_007255146 793 VLIV-PQDTM-------TGVm-K--GTRVQHHSAVER-----WKGVHLYKRFVYLCEQemAasvkc--aeagvT--VKHG 852 Mexican tetra
5_pfamImport  77 VLLV-PQDSL-------LGEpLP--RRRVQYRGGCEL-----WRGAQLFSSLVAACRDlmDgsakc--akagvA--VEQG 137
CAF97517      85 LLIV-PQATL-------GGK-AK--GRAMQYHTDISK-----EDGLRLHSAFVSLWEQevAka--------gpT--VRHG 138 spotted green p...
1JKE_C       124 RFAADMQVSLVNDGPVTFWLQ 144 Escherichia coli
XP_002996706 121 PINGKYNINVCNQGPFTIIFE 141 Nosema ceranae BRL01
XP_002413647 135 TYGDRQVLSMETNGPFTHVLD 155 black-legged tick
7_pfamImport 142 TYGNRQVLSLDTNGPFTHLMS 162
Q4SCI4       141 SYGNRQVLSLDTNGPFTHLME 161 spotted green pufferfish
XP_005455994 147 TYGNRQVLKIDTNGPYTHLME 167 Nile tilapia
XP_005814469 148 TYGQRQVLQLDTNGPYTHLMD 168 southern platyfish
XP_007255146 853 VYGNMQTMYLNSNGPLTHVIE 873 Mexican tetra
5_pfamImport 138 VYGQRQEMVLSAAEPMTLLLE 158
CAF97517     139 ttatgrc-------------- 145 spotted green pufferfish
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