1Z9T,6DZD,1XFJ,1RV9


Conserved Protein Domain Family
Cu-oxidase_4

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pfam02578: Cu-oxidase_4 
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Multi-copper polyphenol oxidoreductase laccase
Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.
Statistics
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PSSM-Id: 396916
Aligned: 627 rows
Threshold Bit Score: 157.261
Threshold Setting Gi: 159893281
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Z9T_A                   32 STRIG-G----VSLP-PYDS---------LNLG-AHC---G---D--------NPDHVEENRKRLFAA----G--Nlpsk 75  Esch...
jgi:Haur_3725            45 ATRYGpPaevgAA-RrTFARvagidagrvAHFAlTHSsrvGlvsDpdsmpidsTPHRISV-RGLLADAsprdL------- 115 Herp...
BAM00588                 25 STRHG-G----ISPE-PWRS---------LNFS-VAR---G---D--------MPERVQENRRRLAAA----LglRa--e 68  Cald...
WP_013560249             27 FTRHG-G----VSPS-PWAS---------LNMA-TSV---G---D--------SRENVLENRARALRA----LtpEp--r 70  Anae...
jgi:FsymDg_3108          35 TTRDG-G----VSTG-RYAS---------LNLG-LHV---G---D--------DDAAVLANRAKVADA----LgaEl--d 78  Cand...
CCX56929                 38 TRRFG-G----VSKK-PFDS---------FNLG-LHV---G---D--------DIEAVWENRRRLAKH----LrvGp--e 81  Veil...
PRJNA437124:C6362_02335  29 TGKSG-G----VSEA-PFTS---------LNLA-LHV---G---D--------RPKDVLENRRRLCAL----LgyPl--q 72  Mega...
WP_013251955             31 TERHG-G----VSTG-DFSS---------LNLG-DAC---G---D--------DPAAVAENRLRALAA----LgaEglsg 76  Olse...
jgi:Apar_0490            14 TERTG-G----FSKG-EFAS---------LNLG-GRC---G---D--------NLQHVQKNRQLVLEA----LgaGehfs 59  Atop...
jgi:Elen_2085            41 TGRAG-G----VSEG-PYSS---------LNLG-NHV---G---D--------DPASVERNRALVLEA----LdaAd--v 84  Egge...
1Z9T_A                   76 PV-WLEQVHGK--DV---L----KL-----TGE--PYAsk----rADASYSNTPGTVCAVXTADCLPVLFCNRAGTEVAA 134 Esch...
jgi:Haur_3725           116 -SfINAQGIPNqqGV-------------------------------DSLITTTRNLALFMVVGDAAPVIITTRQGKAVAL 163 Herp...
BAM00588                 69 DMvHCRQVHGV--NVaqvG----WE-----NAGavi-------dgCDGLITDAIGLPLSLVFADCAPILIYDPDHHALGV 130 Cald...
WP_013560249             71 GIfDVWQVHSN--RVv-yT----RQ-----PRSlgep-----hqqADAIITDNPEVVLLMMFADCVPILLFDPGHHAVGI 133 Anae...
jgi:FsymDg_3108          79 NFvFCEQAHRR--NVavvT----DE-----HRGrgARSaadaipaTDALVTAVPGVILVVMVADCVPLVLHDPVAGVLAC 147 Cand...
CCX56929                 82 LLtCAQQVHGT--EIsevT----EA-----NVGagAFQmdkaipnSDAIFTRLEEVPLLLLVADCVPVLVYDPNHHAVAV 150 Veil...
PRJNA437124:C6362_02335  73 KLtTAQQTHED--HVvavG----PA-----EIGcgAGSyadalahTDAIMTNLPGVPLLLCIADCVPVIVYDPVKQAVAV 141 Mega...
WP_013251955             77 RLvNPRQVHGD--HVvvvTsseaAElasvrNEAge---------gADAVVCTAAGVPVLLCYADCVPVVLVAE--GGFAV 143 Olse...
jgi:Apar_0490            60 RLlIPHQVHGS--TVvclSsdtsEAfeqakTEAea---------gADAIVCTVQNTPVLLAFADCVPVILVAP--GGFAV 126 Atop...
jgi:Elen_2085            85 PLvVPSQVHGE--VVvelDdaspEAldaarEAAla---------gADALVATVPGIAALLCFADCVPVIVVSP-TGRFAV 152 Egge...
1Z9T_A                  135 AHAGWRGLCAGVLEETVSCFaD---------NPENILAWLGPAIGPRAFEV-G----GEV-REAFXAVdakasa------ 193 Esch...
jgi:Haur_3725           164 VNVGLVGTVNNVLENTIEALcHlv-----acQPSDLVVGIGPTVGPCCYALaQsltwAQVvSPAF-FQrhg--------- 228 Herp...
BAM00588                131 VHAGWRGSLDGAAPALLGAMqAay-----gaDPSRMLVCIGPSIGPESYEV-G----PEV-AALAQKRlpapnaa----l 195 Cald...
WP_013560249            134 AHAGWKGTVAKVARESVLSMkQaf-----gtKPEDLLAVIGPSICPEHYAV-G----SEV-THAVREAfgndss------ 196 Anae...
jgi:FsymDg_3108         148 VHAGWGGTVRGVTPAAVTAMrQlg------sEPRDIVACVGPAIHPDRYQV-G----ADV-VDAARAAfgdqldt----- 210 Cand...
CCX56929                151 IHAGWRGTIGHVPILTMEAMgNay-----gtRPQDCHVYLGPSIHYNSFEV-S----EEL-AETF-RKasyipdqivgyr 218 Veil...
PRJNA437124:C6362_02335 142 IHDGWRGTVQRLAAKTVFAMrLay-----gsDPKDLLAYVGPSISRSHYQV-S----EDT-AMAF-RRlgpdya------ 203 Mega...
WP_013251955            144 IHSGWRGTIARISAKALATLaTetg----haP-QEVRAYVGPHIAGEDYEV-S----AGL-MGRFVDEfgp--------- 203 Olse...
jgi:Apar_0490           127 AHSGWKGTIARISACTTETLcQatg----akP-SEVKAYIGPHIGSADYEV-S----SEL-IQMFSQEfgpnv------- 188 Atop...
jgi:Elen_2085           153 AHAGWRGVENGVAAKAVRALaRadaaelgedAASGYNVYVGPHIHASCFET-G----ADV-RKRFEDRfgs--------- 217 Egge...
1Z9T_A                  194 -afiqhGD----Ky---lADIYQLARQRLANVGV--EQIFGGDRCTYTEN-ETFFSYRRdK-TT-GRXASFIW 253 Escherichia...
jgi:Haur_3725           229 ----pnAPgiiiRdeqyfFDLPRMIGHILEQTGVqtSNIHSIDLCTACPD-TAFFGHYAg---VaGRFGALVA 293 Herpetosiph...
BAM00588                196 hrpngaQC----Np---hLNLWEANIQLLVAAGVarNHIEVSGIDTAQNT-QDFFSHRAeKgRC-GLFCMVAW 259 Caldilinea ...
WP_013560249            197 evllqeNG----Vi---sLDLWRANQIILTQAGVlaDHIQTVEICTAEHT-RDWYSHRAeMgKT-GRFAAMIG 260 Anaerolinea...
jgi:FsymDg_3108         211 vvrpdgTG----Rw---tFDLWRANTLQLVAAGVpaGQVHVTALGT--GPdSPFFSHRAgG-PC-GRFAAVAr 272 Candidatus ...
CCX56929                219 yradkgIQ----Tp---hVNLQQFIVQDLRQIGVplQQITVSPTDSMTAP-GC-YSYRReFgKT-GRMALFAM 281 Veillonella...
PRJNA437124:C6362_02335 204 acagetDG----Vw---sVDLWQANRLLLLEAGLapDHVEVTTSCAFSEA-DKFFSYRRdGgHT-GRMGAFAV 267 Megasphaera...
WP_013251955            204 ---aaqAG----Er---lLDLEACIVQTLVEEGVpaDMIAGTHASTSRET-GRFFSYRAtGgSC-GRHGALVV 264 Olsenella uli
jgi:Apar_0490           189 --vdraSG----Er---yLDLGYAVRAALIDAGVreSAIEEVTDSTASTT-ERFFSYRAeHgKC-GRHAAVAy 250 Atopobium p...
jgi:Elen_2085           218 ---sciPD----Er---hVDLLEALTVGLEEAGIdrARVADAGVCTVCSC-DEFFSYRAaGgIC-GRHGAVAf 278 Eggerthella...
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