1SJ5


Conserved Protein Domain Family
DNase-RNase

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pfam02577: DNase-RNase 
Click on image for an interactive view with Cn3D
Bifunctional nuclease
This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.
Statistics
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PSSM-Id: 396915
Aligned: 234 rows
Threshold Bit Score: 85.9645
Threshold Setting Gi: 123750313
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SJ5_A              32 VILGIEGTNrVLPIWIGAAEGHALALAME-KME--FPRPLTHDLLLSVLESLEARVDKVIIHSLKDNTFYATLVIRdlty 108 Thermotog...
WP_011939953        21 IILKDDAGEnSVPIWISTQESVSLAVELIsRDI--SFQSGRGDLLTVLMQQMGMRIEKIAIESLRDGVFAASVKFGgks- 97  Geobacter...
jgi:Geob_2179       21 IILKDDAGEnSLPIWIGQQESVPVALELInRDL---IRAGSGDLLTALMQQLELKIESIAIESLRDGVFNACVKFSgkr- 96  Geobacter...
WP_013161126        20 MVLRVVGSTrYLPVWVDTVSAAALMSVVG-GEL--EGPALTFDLFSKLLSRLGDPALSGRITGWDDGVYSAELVVDg--- 93  Propionib...
Q6NHD2              22 LVFSWSERRrILPIWVDVEEGIRLSERSE-HGA--PRRPLAHDVLIETINRMGGSVEAIRVVSYYEGVFICSLVLDn--- 95  Corynebac...
ADL10475            22 IILRWPERNrILPVWIEETEAFAIAARDE-DEQfgARRPLTHDLLVHALSRIGSPVVELRIVSYHEGVFLCSLVLSd--- 97  Corynebac...
WP_025252776        22 AIFRWRERNrYLPVWMSVDDALLIEAREA-DAA--PRRPLTHDVLVETLTRLTSGVSEIRIVSYYEGVFIASIVLNd--- 95  Corynebac...
CeBiTec:B841_06610  22 AILRSPEDGkILPIWISIVEGSNLAAREQ-DES--PRRPGTHDLLADVLSRQEGDTPTIAITSHYEGVFVTTITQAg--- 95  Corynebac...
Q8FTJ3              24 AVFRWEDGNkVLPIWMDQDDALRIQAYHS-GYR--PRRPGVHELLADAFTRNGPWVSNLRIVSHFEGVFMASVITSe--- 97  Corynebac...
CeBiTec:A605_07095  22 VVLRWAEQKrILPIWLSPLAAAELEIRDK-GYS--PRRPGSHELLAETLTRLTSGVSGINIVSHYEGVFIASIVLNd--- 95  Corynebac...
1SJ5_A             109 tdeedeeaalIDIDSRPSDAIILAVKTGAPIFVSDNLVEKHSIELE 154 Thermotoga maritima
WP_011939953        98 --------kkHLVDVRVSEAMMAALKYKLPVMVHEEVVKQAPMldl 135 Geobacter uraniireducens
jgi:Geob_2179       97 --------kkIRVEIRVTEALLTALKYKIPVMVHEDVVREAPLldl 134 Geobacter daltonii FRC-32
WP_013161126        94 ----------EPIAARVSDIAALAFVRGFTITCPDELVAQLGVEAF 129 Propionibacterium freudenreichii
Q6NHD2              96 ---------qEEIDCRPSDAIAISELIGVAISVDDEVLNQASVFVP 132 Corynebacterium diphtheriae
ADL10475            98 ---------gEEIDCRPSDGIIVARMLGIPVMAEESMLNQVSVFVN 134 Corynebacterium pseudotuberculosis C231
WP_025252776        96 ---------gEELDVRTSDALAVARIMGLPILADEEVLAQASIFIA 132 Corynebacterium vitaeruminis
CeBiTec:B841_06610  96 ----------EEFDARTSDALVLSQILDIPILIDEDVWSQTAIFLS 131 Corynebacterium maris DSM 45190
Q8FTJ3              98 ---------gEELDARPSDILMLSELLELPIAADEEILQQCAVFVN 134 Corynebacterium efficiens
CeBiTec:A605_07095  96 ---------gQEIDARASDAVILARMFEMDIHVDEDVLLQASVFVS 132 Corynebacterium halotolerans YIM 70093 = DS...
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