5DMN


Conserved Protein Domain Family
S-methyl_trans

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pfam02574: S-methyl_trans 
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Homocysteine S-methyltransferase
This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.
Statistics
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PSSM-Id: 396912
Aligned: 697 rows
Threshold Bit Score: 92.2413
Threshold Setting Gi: 407050681
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DMN_B               17 LLLDGAMATEL-E----ARg-cNlADS---LWSAKVL--Ve----NP--------------E---L-------------- 50  Escheric...
XP_003369425          8 LVLDGSMATTLiNagc----dyIeWKNllkNYNIYFC--LmnfqlEY--------------VtefE-------------- 53  Trichine...
6_pfamImport          1 -LLDGSMSAQL-Saf-----gyNtEDH------------------KPhwtf-------panEdleL-------------- 34 
EGT54809              5 rlLDGSMSEQL-KqfgyNC---NdINN------------------KPhwtf-------panSdqsL-------------- 41  Caenorha...
EFO96913              3 rLLDGSMSAQL-KhfgyDC---NsAEN------------------IPhwtf-------panSdesL-------------- 39  Caenorha...
EFN76194              5 IVLDGALDKQLsR------------------------------------------------NmphIsetdevlamralmy 36  Jerdon's...
XP_011151929          5 LVLDGDFEAQLlRr------------------------------sKHanevgksfmlqvitSepyS-------------- 40  Jerdon's...
CCG83854              3 LVLDGGSTSVL-DyvsetektdLmSSP---LWTSQAL--Fs----CP--------------A---A-------------- 41  Taphrina...
WP_013695471         10 rILDGGMGQEL-L----NRgvkpe---gtlwgATALLhkK-----YH--------------K---I-------------- 45  Candidat...
jgi:HIMB59_00003030   1 MILDGGMGQTL-I----KYgmipq---gtlwsATALLdsS-----LH--------------Q---M-------------- 36  alpha pr...
5DMN_B               51 ----IREVHLDYYRAGAQCAITASYQATPAg-----------fAAR--G---L-DeaQSK-A------LIGKSV---ELA 99  Escheric...
XP_003369425         54 ----CILFYSSFLKVGADIVQTNTYQACISrl----------qDVL--G---I-SirESY-E------IVEYAA---SLA 103 Trichine...
6_pfamImport         35 ----MKQVYQSNLSTGADVVTTNTYHFGs-------------------VldtS-IaeNVQkRveferfFEKTCNlmvKLV 90 
EGT54809             42 ----MEKVYRSFLDIGVNNITTNTYHFGs-------------------IldkN-LsgQEEkCklyekyFEDTCSllcNLA 97  Caenorha...
EFO96913             40 ----VANAYKSFLDLGVTDITTNTYHFGs-------------------TldkR-IpeNDSkKkiyekyFKIACSslvKLT 95  Caenorha...
EFN76194             37 dqdaVYKAHLDFLRAGAQIIRTNTYRTTISlfpsafglpicicDQT----------------------RVITAV---ALA 91  Jerdon's...
XP_011151929         41 ----VLQTHMDFLRAGAQLIRTNTHRIST----------------Gs-IgthMnLdsTEVkP------MVDMAV---NLA 90  Jerdon's...
CCG83854             42 ----VEKLYEAYVNAGAQLISCMTYQQS--------------------N---L-TmkHVKdNpeaydlGMRTAL---QSC 90  Taphrina...
WP_013695471         46 ----IVDTHLDFIKAGAEVIVTNSFGSRKR-------------RMIenG---V-L--SKFkS------ANKTAG---ILA 93  Candidat...
jgi:HIMB59_00003030  37 ----VIDAHQDFMRAGAKVITTNNFTVRKL-------------RFSenN---I-L--DKFdE------ALHTAG---LLA 84  alpha pr...
5DMN_B              100 RKAREAY------Laenpq----agtllVAGSVGPYGAYLADgseyrGdY--------------------------H--- 140 Escheric...
XP_003369425        104 RRSIEHF------Iedngrn---ineyyVAGSVGPYAVSLCDgseysGrYi------------------------qD--- 147 Trichine...
6_pfamImport         91 KEAGSNT------E--------------VWGSVGTLATMYHDlseynGkYidlpgsfgylkrrrlrfhvasrlktqYmyi 150
EGT54809             98 QQYDDVQ---------------------VWGSVGTFATKFHDcseynGkYmd----------------------naG--- 131 Caenorha...
EFO96913             96 -EMKDGV------R--------------VWGSVGTLATLYHDmseynGkYmd----------------------neD--- 129 Caenorha...
EFN76194             92 KKAVRKYfeeiggdsnn-iedynqrrplIAGCCDGYNFLpfyd------------------------------vgkItke 140 Jerdon's...
XP_011151929         91 KKAIMKYlhevhdqktsveqynfssrpiLAGCCGSYNATLFDnvfd---------------------------twkLtes 143 Jerdon's...
CCG83854             91 GTSGGKV------S--------------AVLTLGTHAAMLANgaeysHvYh-------------------------D--- 122 Taphrina...
WP_013695471         94 KRAVQESkk--kiL--------------IAGSLPPQHFTYFS-----Dm------------------------------g 122 Candidat...
jgi:HIMB59_00003030  85 KKANQQNivfkdvL--------------IAGSIPTRNQTYMA-----Kf------------------------------e 115 alpha pr...
5DMN_B              141 CSVEAFQAFHRPRVEaLLDA----GADLLACETLPNFSEIEALaeLLtay------praR---AWFSF-TLrDS----Eh 202 Escheric...
XP_003369425        148 TAVSEIRKYYHDQFCaMTMA----RVDFLALETMPSLTEAKIAleVLsey------nhpP---CWVSF-SCkDE----Yr 209 Trichine...
6_pfamImport        151 SSQDTALNYFKTVIA-IFQEk--tVIRKLVFETIPTEREAMAAvsALqq---------fPemkAVISF-TCdKNg----c 213
EGT54809            132 -AEESAYEYYKTILT-LFQEr--tTIRNLIFETIPSQLEGEVAlkVLke---------fKemkAVISF-TFmENa----c 193 Caenorha...
EFO96913            130 -AENTARNYYQTILT-LFQTk--tKVRNLVFETIPLAVEGLMAleALkr---------fPemrAVMSF-TFkENa----c 191 Caenorha...
EFN76194            141 LPISQLLSFHEERIDilVRS----GVDILAFESISCLIEVIAIsqALrk---------yPtirVWITF-LC--------- 197 Jerdon's...
XP_011151929        144 LSLNYLSWFHQQRMQvlLNA----NVDLLTFESIPTLREVDAIitVLkl---------hPtarALITFlCT-ENg----k 205 Jerdon's...
CCG83854            123 EDRATLKDFHTERLSkfSSMpswaQVQYMAFETLPDVLEAEIIldVLdelkdklslsvkR---TWISF-SC-SGegaiNk 197 Taphrina...
WP_013695471        123 TDLNVIKEYFYEQAK-ILNP----YVDFFYLDVMSSFKECEIA--IKaiap--------lkkdFLVGI-HIrEGe----k 182 Candidat...
jgi:HIMB59_00003030 116 LSVEEIFNEFQCSGE-ILND----YVDIFYLDVLSSLEEIKLA--LKalkk--------fqkkFLIGV-HIkKNs----f 175 alpha pr...
5DMN_B              203 LsDGT----PLRD-VVALLAGyPq--VVALGINCIA-LENTTAALQHLhgl---------------------------tv 247 Escheric...
XP_003369425        210 TnYGD----LFSDvVYE--ISrCp-gVTAVGINCTK-PDFISGLLKQArnv----------------------------l 253 Trichine...
6_pfamImport        214 LrHGE----KITNvAKELENNkQ---IVGIGVNCTD-PSNITAALLEIrhc----------------------------n 257
EGT54809            194 LrHGE----HVADiAKKLKESeQ---IIGMGINCTD-PKNVLPVLEAIknc----------------------------e 237 Caenorha...
EFO96913            192 LrHGE----EIDTlAGELRKCsQ---IVGMGINCTD-PENVLPALKVIkkh----------------------------n 235 Caenorha...
EFN76194            198 KmNGDllddNLLItAIMLCKEtLpgqLMAVGVECQY----IASSLEPIrtlmrninnfkdwvfpflfyidknhlstmtvp 273 Jerdon's...
XP_011151929        206 LlDGS----NFAD----------------VAVHCYNsLTNqif------------------------------------a 229 Jerdon's...
CCG83854            198 VlAG----------VQRLLKHnKidlLWGVGINCFK--ENMAGVVAPFcdllae-------------------------- 239 Taphrina...
WP_013695471        183 LpSGE----DFVSvVKKLSKL-N---PLGVVVACVSvEH-LEPLIKKIlki----------------------------k 225 Candidat...
jgi:HIMB59_00003030 176 MeDGN----CITQlKDLIDQY-D---ILGLVVACTDqST-VLSVIKKIhnl----------------------------q 218 alpha pr...
5DMN_B              248 lP----LvVYPNS---GEh------------YD------AVSKTWH----Hhgehcaq---------------------- 276 Escheric...
XP_003369425        254 mP----FvVYPNS---GR--------------W------TRATGWVeppyYskpig------------------------ 282 Trichine...
6_pfamImport        258 fQe---IfVYPNv---GDatfld---nekdeEDvfkfdlIAS-------------------------------------- 290
EGT54809            238 fSd---IfVYPNl---GDaffmvaekgdfddSDnydhrlRS--------------------------------------- 272 Caenorha...
EFO96913            236 fPe---VfVYPNm---GDskfln---egsdeSDvfnidmVTG-------------------------------------- 268 Caenorha...
EFN76194            274 vD----A--------------------------------AGPSRPVqpvaQ----------------------------- 288 Jerdon's...
XP_011151929        230 iG------TEAN---------------------------NAIADWTlqvmKninynredkipfvlyvsqsqlhtmwgedk 276 Jerdon's...
CCG83854            240 -kqlyaV-IYRDA---GPq------------WD------PVRRVFVgetm------------------------------ 266 Taphrina...
WP_013695471        226 iPfgfkInAFQHipagWKpdsnnpnvklgkrKD------LTPATFYsiskK----------------------------- 270 Candidat...
jgi:HIMB59_00003030 219 vPfgfkVnAFANipdgWKikpgnpteslgvnKS------FNSESFIsfaeK----------------------------- 263 alpha pr...
5DMN_B              277 -----ladylpqWQAAG-AR--------L--IGGCCRTTPADIAALKA 308 Escherichia coli K-12
XP_003369425        283 -------ervqeWIELG-AR--------I--IGGCCGVSPMQLAEVSK 312 Trichinella spiralis
6_pfamImport        291 ------------WVDSG-AT--------V--IGGCCGVQNKQLLSL-- 313
EGT54809            273 ------------WIEHG-AT--------A--LGGCCGIDLDMIQDLRS 297 Caenorhabditis brenneri
EFO96913            269 ------------WVENG-AT--------A--IGGCCGVTEAQMKILKK 293 Caenorhabditis remanei
EFN76194            289 ------------WLDIG-----------VryVGGGFGTNAEDIKEICR 313 Jerdon's jumping ant
XP_011151929        277 fslsqqhnyvqdWLDAG-----------IccIGGGSNTVAQDIRMICK 313 Jerdon's jumping ant
CCG83854            267 --------splaWAERAaADakynggsvV--IGGCCQTTPQHIAALQA 304 Taphrina deformans PYCC 5710
WP_013695471        271 ------------IHKAG-AT--------I--LGGCCEITPKHIARLKK 295 Candidatus Pelagibacter sp. IMCC9063
jgi:HIMB59_00003030 264 ------------CRLEG-AS--------I--LGGCCEVLPNHIKALAD 288 alpha proteobacterium HIMB59
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