6AC8,4KBM,2LWJ


Conserved Protein Domain Family
CarD_CdnL_TRCF

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pfam02559: CarD_CdnL_TRCF 
CarD-like/TRCF domain
CarD is a Myxococcus xanthus protein required for the activation of light- and starvation-inducible genes. This family includes the presumed N-terminal domain, CdnL. CarD interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus. This family also includes a domain to the N-terminal side of the DEAD helicase of TRCF (transcription-repair-coupling factor) proteins. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription. This domain is involved in binding to the stalled RNA polymerase. The family includes members otherwise referred to as CdnL, for CarD N-terminal like, whichdiffer functionally from CarD. The TRCF domain mentioned above is the RNA polymerase-interacting domain or RID.
Statistics
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PSSM-Id: 396900
Aligned: 806 rows
Threshold Bit Score: 37.0419
Threshold Setting Gi: 256558948
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6AC8_A          535 LTAGDLVVHDQHGIGKFVEM-------TERvvggarReYLVLEYAsskrggGt-DKLYVPMDSLDQ--LSRYVGGEApsL 604 
jgi:Ocepr_1808    6 FNVGDPVVYPAQGGGYIREIaerevmgERN------T-YYVIELL------RkpGTIMVPVEKAERlgLRPPLAGAD--R 70   Oceanitherm...
AEB11402          2 FQVGDAVVYPAQGAGRIVEVverevmgSRK------Q-YYVVQLL------SdaARIMVPVGAVREagLRPPLAAAE--L 66   Marinitherm...
jgi:Mesil_2613    2 FAIGEAVVYPAHGAGRIVGLdersvlgEKR------I-YYVLELL------GqaHTVMVPVG-VAQacLRPPLAGAA--V 65   Meiothermus...
jgi:Trad_2545     2 FKVGDNVVYPSQGAGRVDEIttrvvlgERH------E-YLKISFV------RgdMDVLVPLKKGEEvgLRHTVALAE--V 66   Truepera ra...
WP_014683960      6 FQTGDRVVLPPYGVGRIRGTcqrsvagETH------A-YYQVEFP------AttSLAYVPVAAPQTtgIRTALAAAD--M 70   Deinococcus...
WP_015236706      9 YNPGDRVVLPPYGIGVVCGIskrrineATF------S-YYQVEFP------NstSRAYVPVDAPGGvgMRPALTGAD--M 73   Deinococcus...
jgi:Trad_2473     8 YKHGDQVVLPPYGVGVVAGTtvrtvagTDH------H-YYEVEFP------NgtSKAFVPVAAPQAagLRPALTKAE--V 72   Truepera ra...
WP_013159455      4 YRPGDKVVLPPYGVGVVASImqrtisgNQR------A-YYQVEFP------NtrSKAYVPVESPQSarMRPALCREE--I 68   Meiothermus...
WP_015236665      7 LAPGDQVVYPKHGPGVVRAItqrsvggEVR------P-YYDIELR------TggMQVLVPVEKASAlgLRRVLTKDE--V 71   Deinococcus...
6AC8_A          605 SRLG--------------GSDWANTKTKARRAVREIASELVAL 633 
jgi:Ocepr_1808   71 DALVralgear-dlasgwPARQREIGRALSESDPLELARMLAs 112  Oceanithermus profundus DSM 14977
AEB11402         67 ERLWqalaedl-plpsvwMPRYREEQRLLASGDPFKLAALVGT 108  Marinithermus hydrothermalis DSM 14884
jgi:Mesil_2613   66 ERLLdelktev-klptiwMQRHREEEKILASGDPYQVAALAgt 107  Meiothermus silvanus DSM 9946
jgi:Trad_2545    67 GELLaaiahsdlslptqwPPRHRAEQDILAGGDAYALARLIGV 109  Truepera radiovictrix DSM 17093
WP_014683960     71 PVLLhalqtgqlnlphqwSARHRYVSDLMSSGNAHDLAILIGe 113  Deinococcus gobiensis
WP_015236706     74 PELLnhlrdghmnlprqwAARHRKVTEILVSGDPYELASLase 116  Deinococcus peraridilitoris
jgi:Trad_2473    73 HKVLerlsngrinlpkqwAARHRRVTEILSSGDPYQIATLgse 115  Truepera radiovictrix DSM 17093
WP_013159455     69 EEILellrngrlslprqwAARHRKTSEILAEGDPYRIATlagq 111  Meiothermus silvanus
WP_015236665     72 PRLLsvlqgpdtqlpsafPPRHRLQQAILEGGQLYEVAQLAGT 114  Deinococcus peraridilitoris
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