7K1W


Conserved Protein Domain Family
Syja_N

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pfam02383: Syja_N 
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SacI homology domain
This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.
Statistics
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PSSM-Id: 426748
Aligned: 455 rows
Threshold Bit Score: 107.275
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7K1W_F        104 FGVVGF--VRflEGYYIVLITKRRKM-ADig--gH-AIYKVEDTNMIYip-----nD------Sv---------Rv---- 153 
Q38DV2         90 YALFGV--LRigSASILLYVSERERI-TTltigeThDVFAVKQLSWLRlpetasdlS------Vnksgd-ggdgGsgekd 159  Trypanosoma b...
XP_001608593   74 EGILGC--IRflNYPYLYVITKKERVaVLl---nEhKVYLVKSVLLIPf--------------Rdd-------vFg---- 123  malaria paras...
XP_002808809   75 EGIFGC--IRflNYPYLYVLIKKEKVgILf---dEhKIYNVKNILLIPf--------------Ved-------iFd---- 124  Plasmodium fa...
Q7RGR5         74 EGILGC--IKflNYPYLYVVTDKEKIgVLf---nEhVIYSVKSVLLISf--------------Ked-------iFe---- 123  Plasmodium yo...
XP_002953781   69 PYILGYvvIG--Q-WGLLLVAEKFRVsAIlp--gThEVKTVTKSHWLKiplqinlsM------QsvqvcnllynRgyqag 137  Volvox carter...
XP_003059495   47 DACLGVvaVG--D-AVLLLLARKTKVaATlp--nGhEVMSVQEARWHRa--------------Alr-------nPa---- 96   Micromonas pu...
Q57WG4        116 AALFGC--LRl-DRMYFLVATKVEEA-AVlp--fGgAILRVGGTEWISfgipgsepLyltsg------------------ 171  Trypanosoma b...
XP_003283904  116 LAILGY--IIseKSSHLLVATKIRNEgELl---gCyPINTIIETSWIKidlsylssYqsneiqNdeawtttfveEtnidp 190  Dictyostelium...
EGG23944      141 CAILGY--IVadRSAHLLVATKVRSEgELl---gLhPISVVLESSWIKielsypssYqpkmdtNssattsssttSnlnss 215  Cavenderia fa...
7K1W_F            --------------------------------------------------------------------------------     
Q38DV2        160 ----------------------------------------------------------------------------easa 163  Trypanosoma b...
XP_001608593      --------------------------------------------------------------------------------      malaria paras...
XP_002808809      --------------------------------------------------------------------------------      Plasmodium fa...
Q7RGR5            --------------------------------------------------------------------------------      Plasmodium yo...
XP_002953781  138 itvegswhgm---------------------------------------------------------vegmggglwgawg 160  Volvox carter...
XP_003059495      --------------------------------------------------------------------------------      Micromonas pu...
Q57WG4            --------------------------------------------------------------------------------      Trypanosoma b...
XP_003283904  191 svssstsgallnnnsflns---------------------------------------fsssssppssnanynnsnnsdl 231  Dictyostelium...
EGG23944      216 sssvqqqqqqqqqqqqqqqdlnnnndnnvnnnnnsfnihgsnfstigsfsvgsygssigslpntsnlsssvggstqlhfn 295  Cavenderia fa...
7K1W_F        154 -Th----------------pDEAR---YLRIF-----------QNVD---LSS--NFYF--SYs---------yDLSHSL 186 
Q38DV2        164 sQgssq-----------shaREEMvleYCRVVd----------SFCAqseQHCgaSYFY---YsptanltlepgDVVKGM 219  Trypanosoma b...
XP_001608593  124 -Nf----------------nDENE---LV--------------QLFYnsvNHK--HIYFsyTY-----------NLPCSV 156  malaria paras...
XP_002808809  125 -Ny----------------nEENE---LI--------------DLFYnntNHK--YIYFsyTY-----------NLTYSV 157  Plasmodium fa...
Q7RGR5        124 -Ki----------------nHENN---LV--------------QIFYnsaNHK--YLYFsyTY-----------NLANSL 156  Plasmodium yo...
XP_002953781  161 kApeagakd----ekamkdeIEKG---IERLLsfp------------------idGAHF---Lcd-------tlDITRPF 205  Volvox carter...
XP_003059495   97 -Ras---------------tREER-------------------ANVAsmtEATmdNLYY---Yce-------tfDATRAF 131  Micromonas pu...
Q57WG4        172 --------------------------------------drnrlKEFEtysHEG--GYYY--Sdd---------cDLRRPF 200  Trypanosoma b...
XP_003283904  232 pTtat------------ssnItsndpt-----------vkeilKDLQtfpFDG--THFYceNY-----------DLTNYF 275  Dictyostelium...
EGG23944      296 gQsqhsqqqqsqqtqqtqqsQQSQsqdDNGLPsesnittqtllNNLQsypIDG--THFYceSY-----------DLTNYF 362  Cavenderia fa...
7K1W_F        187 QYNltvlrmplemlkseMTQnr-------qeSFDIFEdeglitqggsgvfgicsepyMk------------YV------- 240 
Q38DV2        220 KEV--------------LTPslng---ssvkGGGAFS--------------------LaissegqisqrvvFQ------- 255  Trypanosoma b...
XP_001608593  157 QVN--------------FYLqkeflrggiihSRDYAN--------------------E-------------YL------- 182  malaria paras...
XP_002808809  158 QEN--------------YFIqknyl--kggnVKYKNN--------------------P-------------YM------- 181  Plasmodium fa...
Q7RGR5        157 QNN--------------YFIqkeylkgniiyNKKYKN--------------------N-------------YI------- 182  Plasmodium yo...
XP_002953781  206 PSY------------------------------RAVK--------------------Dps---------wdFV------- 219  Volvox carter...
XP_003059495  132 AHA--------------CRNaasts-vtptkEPPPPD--------------------Pe------------WV------- 157  Micromonas pu...
Q57WG4        201 P----------------------------------------------------------------------FVsskdgng 210  Trypanosoma b...
XP_003283904  276 PSN--------------YNTt----------PFQYCS--------------------E-------------FA------- 291  Dictyostelium...
EGG23944      363 PSN--------------RTT-----------PYQFNS--------------------E-------------FT------- 377  Cavenderia fa...
7K1W_F        241 ------WNGELL-Diik------stVHRdWLLY-----IIHGFCgq-skLliygrpvYVTLIARRSSKFAGTRFLKRGAN 301 
Q38DV2        256 ------WNSPLLgAfdevvaslncdYHV-YVPA-----FIRGIVea--tTspe-egvQMLLINRLSYRWAGTRYNRRGLD 320  Trypanosoma b...
XP_001608593  183 ------WNGYHCkAfvrq--------nvfICVP-----TISGFYvq-skFlcegkaiDVTFIARRCNKYAGTRYRKRGIN 242  malaria paras...
XP_002808809  182 ------WNSYHSkYfikq--------nifLCLS-----IINGYFiq-skFlcsgkiiDISLVGRRSNKYAGTRFRKRGLN 241  Plasmodium fa...
Q7RGR5        183 ------WNFYHCkPflkk--------nifICLF-----VINGYLiq-skIsfsgkyvDIIFVARRSYKYAGTRYRKRGIN 242  Plasmodium yo...
XP_002953781  220 ------WNRWMSaPfrn------lgLDH-LCPP-----LLQGLCesrllEdfdnakyWVACISRRGCLHPGPRYKARGLN 281  Volvox carter...
XP_003059495  158 ------WNAWLAkP-----------LND-LCIPracpaLLQGLAesralidavgapwRVAVFGRRSRAHPGTRYIARGLN 219  Micromonas pu...
Q57WG4        211 pqfhsdWSRQLRkPfit------agVES-CCSV-----LLRGFAaekevLlkdgsilHVLLCGRQNNLNPGPRYFGRGLN 278  Trypanosoma b...
XP_003283904  292 ------WNEWMRkP-----------FEN-ASLShlcvvLLQGYVsi--kPlst-lnaSIGYIMKRSKLNPGTHFFSPGIN 350  Dictyostelium...
EGG23944      378 ------WNEWIRrP-----------FDQ-VSLSnlcvvLLQGYAsi--rYiqa-lntTTCYIMKRSKLNPETLYHGHGIN 436  Cavenderia fa...
7K1W_F        302 CEGD--VANEVETEQILC-Dasv--------------------------------------------------------- 321 
Q38DV2        321 NAGSgiAANFSASTLWVFpLasgne------------------------------------------------------- 345  Trypanosoma b...
XP_001608593  243 AKGY--AANQVETELILFqRn----------------------------------------------------------- 261  malaria paras...
XP_002808809  242 SYGY--SANDVESEIILFeKn----------------------------------------------------------- 260  Plasmodium fa...
Q7RGR5        243 YNGF--SANEVESEIILHeKn----------------------------------------------------------- 261  Plasmodium yo...
XP_002953781  282 DYAE--PGNELEVEQVIWrQqq---------------------------------------------------------- 301  Volvox carter...
XP_003059495  220 ADAA--PGNEVEMEQIAWrEeeeeeeekggpetkgndasa-------------------------------------sag 260  Micromonas pu...
Q57WG4        279 AVNA--VGNDHVYEYVMWrQgg---------------------------------------------------------- 298  Trypanosoma b...
XP_003283904  351 ENAS--PANEYENELIMWkYedqqiiisspdssknnnnannnntgvnskdskdvnnsdnsnnsdekkhkedekhenhdns 428  Dictyostelium...
EGG23944      437 DRAG--ASNEYECEIIMWkYt----------------------------------------------------------- 455  Cavenderia fa...
7K1W_F        322 --------------msFTAGSYSSYVQVRGSVPLYWSQDISTM-----------Mp---KPPitldq-adpfaHVAALHF 372 
Q38DV2        346 -----------gdkaaNEKQRVAAFTILRGSVPRCWSQPANLTf---------------IPTitiss-pssgvDELVLHL 398  Trypanosoma b...
XP_001608593  262 ----------------YE-TAILSYVQLRGSVPVFWTQGVN-------------YhllkRPKikckk-ydaffTCTKRHF 310  malaria paras...
XP_002808809  261 ----------------NS-HVILSYTQLRGSVPIFWNQQVN-------------YkilkKPQinflk-tdinySCTQKHF 309  Plasmodium fa...
Q7RGR5        262 ----------------NISNGILSYVHLRGSVPVLWNQSIN-------------YkllkKPKikcme-ndinfICTKKHF 311  Plasmodium yo...
XP_002953781  302 --------------rdGSLLLWSRYTWRRGSAPLWWGVSIKNNgigea-------eikiRPHnt--------fKGSKRYV 352  Volvox carter...
XP_003059495  261 ggviggetnqnqtpkkTARARWSAYVWRRGSVPIRWGQEIKQSi--------------gDAEitvaa--ddpyAGTATYF 324  Micromonas pu...
Q57WG4        299 ---------------gNGPIQFAKHTILRGTVPVHWSTRISKTi--------------sEPAmmfsqnkeevlRGCDSYF 349  Trypanosoma b...
XP_003283904  429 kketnlknenivfksgDKVIKWTSHIWRRGTVPLWWRAFSKNQgneielflkdrGkdnpNPF-----------EKSEIYY 497  Dictyostelium...
EGG23944      456 ---------------tSQTIQWTSNVWRRGTIPIWWRSRLKQNgsdl--------qvkdNAF-----------ENSEQYY 501  Cavenderia fa...
7K1W_F        373 D----QM--FQRF---------------------GsP----IIILNLVke--rEKrk-hERILSEELVAAVTYLNqf--- 415 
Q38DV2        399 N----AL--LALFd--------------------G------MTSIHCLdttslSKa---ELPISKAFEAAALKLRegng- 442  Trypanosoma b...
XP_001608593  311 R----HL--LARY---------------------GyP----IIAINLLs----KKkqsdESNLSNEYEACIGVINrd--- 352  malaria paras...
XP_002808809  310 Q----RL--YEKY---------------------GyP----ITVVNLLs----KKkysdEQKLSYHYKESIDRLNky--- 351  Plasmodium fa...
Q7RGR5        312 S----YL--FKKY---------------------GyP----ITVVNLLs----KNkysdEDLLSNTYKKCVNLINky--- 353  Plasmodium yo...
XP_002953781  353 R----RL--QERYtpnpqldpdppvagadgepsrHvP----VTFVSLLrkglpDRdr-sEAKLASAFDFVVAQLRke--- 418  Volvox carter...
XP_003059495  325 R----KLveTSRPpasavggdgg--ggaaepaspPfP----VTCVNLLrcapgKP----EMVLSEHFHEAVRGVRkgtnp 390  Micromonas pu...
Q57WG4        350 SfvftQLvaIMRYdsgeq------------ltgrGpR----LRCVNMLr----QShhssEEALTKHFTEAVTKSQaalq- 408  Trypanosoma b...
XP_003283904  498 Q----NL--LNRYqkfye-----------ynkdsNlAgipsIQLVDLLkqegdKQ----ELILSQLYQKCCENVIsy--- 553  Dictyostelium...
EGG23944      502 L----NL--LNRYqhf---------------ydnNkNslpnINLVNLLkt-ddPQ----ESLLSQLYQKSCEKVMsl--- 552  Cavenderia fa...
7K1W_F        416 ---------lPPEhtIV--YIPWDMAKYTK 434 
Q38DV2        443 ------alsrPVD--VY--YTKYNVKERRA 462  Trypanosoma brucei
XP_001608593  353 ---------lPPP--IRiiYRHLDLRKAYK 371  malaria parasite P. vivax
XP_002808809  352 ---------iPKK--IHiiYKHVDLRKAYK 370  Plasmodium falciparum 3D7
Q7RGR5        354 ---------iPTN--IRiiYKHLDLRKLYK 372  Plasmodium yoelii yoelii
XP_002953781  419 ---------hGMN--LT--YIALDWHEMDK 435  Volvox carteri f. nagariensis
XP_003059495  391 dsraspptpsSAA--LA--VVNFDWHGNMK 416  Micromonas pusilla CCMP1545
Q57WG4        409 ------qafpGSQ--LD--LVHVDWLNMLK 428  Trypanosoma brucei
XP_003283904  554 ---------lNVD--LQ--IYSFDWINSLK 570  Dictyostelium purpureum
EGG23944      553 ---------vNVN--LN--LISFDWSGILK 569  Cavenderia fasciculata
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