Conserved Protein Domain Family
PTS_EIIC
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pfam02378: PTS_EIIC 
Phosphotransferase system, EIIC
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.
Links
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Statistics
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PSSM-Id: 367061
Aligned: 49 rows
Threshold Bit Score: 44.6452
Created: 21-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9CJ32        29 RDSFIGMLPATLAGALAAMISAivttfpsaiqqmmLGAtaFSKLAPekvwtLANTPIIGdlnnISALVNQGTLTVIGLIF 108 Lactococcus lac...
Q9K678        19 SGMIMPNIGAFIAWGLITALFI--------------------------------PTGWWpneqLAELVGPMITYLLPLLI 66  Alkalihalobacil...
P69826        18 TAMVIPNIGAFIAWGFITALFI--------------------------------PTGWLpnehFAKIVGPMITYLLPVMI 65  Escherichia col...
Q9ZHJ9       108 GDVFVPIIPVLVATGLFMGLRGll--------------------------tNLGVQMNEnfvlFTQVLTDTAFAFLPALV 161 Clostridium bei...
P43470       111 SDIFIPIVPALVAGGLLMALNN---------------VltAEHLFmak-svVEVYPGLKgiaeMINAMASAPFTFLPILL 174 Pediococcus pen...
P24241       111 IGTMSPLIPAIIGGSMVKLLAMil-------------------------emSGVLTKGSptltILNVIGDGAFFFLPLMV 165 Escherichia col...
WP_002294087 107 SESMTPILEPIICAGLLAAVLSia-------------------------slTGIISPDSstyhIFDALRSAVFYFLPILM 161 eubacteria
Q9K7V5        18 FVTALSFMALGLFSSLIIGLII-------------------------------RTIGDVtqfeLMHNIGVLAMSLMGPAI 66  Bacillus halodu...
P32154       133 MAGVSAALPFVIGGGILVALANm-----------lVQFglPYT---------DMSKGAPsftwVVESIGYLGFTFMIPIM 192 Escherichia col...
Q98R81       304 MSGISYMLPFVVFGGIIISIGFl-----------iDTIygATSGISsdpkfLANFGSNHivakWFNRLGGIAFSIMVAIL 372 Mycoplasma pulm...

Q9CJ32       109 AFSWGYNLarayGVNDLA--GGIVSLATLFAglPNQMGKFTAALgtgkagvaatdklngvlgdqglaAWKPLFASAHLDA 186 Lactococcus lac...
Q9K678        67 GYTGGKMIy--dVRGGVVgaAATMGVVV------------------------------------------------GADI 96  Alkalihalobacil...
P69826        66 GSTGGHLVg--gKRGAVMggIGTIGVIV------------------------------------------------GAEI 95  Escherichia col...
Q9ZHJ9       162 AWSTMKKF----GGTPVIgiVIGLMLVSPSLpnAYAVAAGTATP-----------------------I-NLTILGLNIPV 213 Clostridium bei...
P43470       175 GFSATKRF----GGNPYLgaTMGMIMVLPSLvnGYSVATTMAAGk---------------------mV-YWNVFGLHVAQ 228 Pediococcus pen...
P24241       166 AASAAIKF----KTNMSLaiAIAGVLVHPS---FIELMAKAAQG------------------------EHVEFALIPVTA 214 Escherichia col...
WP_002294087 162 AMSCAKRL----GASPYLavALAATILSSSIndVK----------------------------------GLELFGIGLPQ 203 eubacteria
Q9K7V5        67 GVAVAYGL----QAPRLVlfSALIAGAA------------------------------------------------GAEL 94  Bacillus halodu...
P32154       193 GAYIASSI----ADKPAFapAFLVCYLANDK-----------------------------------------ALLGTQSG 227 Escherichia col...
Q98R81       373 AAYITYSL----VGRQGLlpGFVIGFISSGRlkDTYSFLTDSLTn----------------------NYGLSPDKVLETG 426 Mycoplasma pulm...

Q9CJ32       187 GAYFTVIIMGALAVIIYAKLMLaditIKMPESVPPAV-----AKAFLAIIPTIAALYIVGLIYYIIGKLTNDSVIN-Lit 260 Lactococcus lac...
Q9K678        97 PMFIGAMIMGPLGGFLIKKVDQvl-qPKVRSGFEMLVnn--fSAGILAAILAIVAFLGIGPVVVSFSNVLASGVEViIga 173 Alkalihalobacil...
P69826        96 PMFLGSMIMGPLGGLVIKYVDKal-eKRIPAGFEMVInn--fSLGIAGMLLCLLGFEVIGPAVLIANTFVKECIEAlVha 172 Escherichia col...
Q9ZHJ9       214 VGYQGSVLPALVLGIIAAKTQKal-kKVVPDVLDLIV-----TPFITLLFSMVLGLLIVGPIMHNAEQLIFGAIKG---- 283 Clostridium bei...
P43470       229 AGYQGQVLPVLGVAFILATLEKff-hKHIKGAFDFTF-----TPMFAIVITGFLTFTIVGPVLRTVSDALTNGLVG---- 298 Pediococcus pen...
P24241       215 VKYTYTVIPALVMTWCLSYIERw------vDSITPAVtknflKPMLIVLIAAPLAILLIGPIGIWIGSAISALVYT---- 284 Escherichia col...
WP_002294087 204 ITYSNSFIPILLAIWFMGYVTKvv-kRVIPNTLQYFL-----TPLLVMLITLPATLLIFGPLGFYMGEGIIGFFNLl--- 274 eubacteria
Q9K7V5        95 GGPAGSFVAALLATEVGKVVAG--------------------ETKIDIIVTPFVTVIVGFLTAQFIGPVIQSGMSGlGat 154 Bacillus halodu...
P32154       228 AGFLGAVVLGLAIGYFVFWFRKv----RLGKALQPLL-----GSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHfL-- 296 Escherichia col...
Q98R81       427 SGFVGAILGGFFAATMLILMSKyi-fSKLPKNLYGIR-----DILFIPILGTLTIAFVF-WVLNIVFIYINYGLTIlL-- 497 Mycoplasma pulm...

Q9CJ32       261 hYIaepfQILSQnIFSVLIVTLFVSVFWFFGLHGPNVLAPVLDGI----------WGPLGLnnqalyfqvhsqgirdlia 330 Lactococcus lac...
Q9K678       174 gLLplasIFIEPaKVLFLNNAINHGILSPIGIDQAASAGKSILF------------------------------------ 217 Alkalihalobacil...
P69826       173 gYLpllsVINEPaKVLFLNNAIDQGVYYPLGMQQASVNGKSIFF------------------------------------ 216 Escherichia col...
Q9ZHJ9       284 -------FMGLPfGLGGLVVGGVHQLIVVTGVHHALNALEVELLSst------gkDAFNAM------------------- 331 Clostridium bei...
P43470       299 -------LYNSTgWIGMGIFGLLYSAIVITGLHQTFPAIETQLLAnvak---tggSFIFPV------------------- 349 Pediococcus pen...
P24241       285 -------IHGYLgWLSVAIMGALWPLLVMTGMHRVFTPTIIQTIAetgk--egmvMPSEIG------------------- 336 Escherichia col...
WP_002294087 275 -------MKYVGsWFVMMLYSALQPFIIMLGAGNFIMPVVASLIAang-----ydPAFISS------------------- 323 eubacteria
Q9K7V5       155 iMW----ATEQRpIIMGIVVATLMGLALTAPISSAALAIMLELSG----------------------------------- 195 Bacillus halodu...
P32154       297 -------NTIPPsM--KFAAAFLVGAMLAFDMGGPINKTAWFFCFslle---khiYDWYAI------------------- 345 Escherichia col...
Q98R81       498 -------LIIETrREIIWLLGLILGIMMAVDLGGPINKAAYVFGTltlaqmqgkgTIAMAS------------------- 551 Mycoplasma pulm...

Q9CJ32       331 kgavdkahaingdyvnlwvrgswdafAWFGGSGGTITLVIAIILFSKRKDYKIVGRLGLAPGIFNINEPVLFGLPVVLNA 410 Lactococcus lac...
Q9K678       218 --------------------------LLETNPGPGLGVLLAFMVFGKGMAKQSAPGAAVIHFAGGIHEIY---FPYILMK 268 Alkalihalobacil...
P69826       217 --------------------------MVASNPGPGLGLLLAFTLFGKGMSKRSAPGAMIIHFLGGIHELY---FPYVLMK 267 Escherichia col...
Q9ZHJ9       332 --------------------------ITCGIVAQGAAALAVAVKTKDKKKRSLYISSAI-PAFLGITEPAIFGVNLRFIK 384 Clostridium bei...
P43470       350 --------------------------ASMANIGQGAATLAIFFATK-SQKQKALTSSAGVSALLGITEPAIFGVNLKMKF 402 Pediococcus pen...
P24241       337 --------------------------ANLSLGGSSLAVAW---KTKNPELRQTALAAAASAIMAGISEPALYGVAIRLKR 387 Escherichia col...
WP_002294087 324 --------------------------CTISDIAVGGAMLGYFLRTRNLKQKQLFGTVTL-SAVLGVTEPAIYGVFVKYRR 376 eubacteria
Q9K7V5       196 --------------------------IAAGAATVGCAAQMVGFAVSSYRENGWAGIFSLG------IGTSMLQVPNIVKN 243 Bacillus halodu...
P32154       346 --------------------------VGVVALMPPVAAGLATFIAPKLFTRQEKEAASSAI-VVGATVATEPAIPYALAA 398 Escherichia col...
Q98R81       552 --------------------------VMIAGMTPPLGISVSMFLHKKLWSKQDIEAGKISNILFGLSFISEGAIPYTSRN 605 Mycoplasma pulm...

Q9CJ32       411 I-FFIPFAVAP 420 Lactococcus lactis subsp. lactis Il1403
Q9K678       269 PtLILAVIAGG 279 Alkalihalobacillus halodurans C-125
P69826       268 PlTIIAMIAGG 278 Escherichia coli K-12
Q9ZHJ9       385 P--FIFGCAGG 393 Clostridium beijerinckii
P43470       403 P--FVFAAIAS 411 Pediococcus pentosaceus
P24241       388 P--LIASLISG 396 Escherichia coli K-12
WP_002294087 377 P--FVAVMIGG 385 eubacteria
Q9K7V5       244 PlIILPPTIAG 254 Bacillus halodurans
P32154       399 PlPMITANTLA 409 Escherichia coli K-12
Q98R81       606 TkVMIPSNIIG 616 Mycoplasma pulmonis
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