Conserved Protein Domain Family

pfam02370: M 
M protein repeat
This short repeat is found in multiple copies in bacterial M proteins. The M proteins bind to IgA and are closely associated with virulence. The M protein has been postulated to be a major group A Streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsonophagocytosis.
PSSM-Id: 111279
View PSSM: pfam02370
Aligned: 59 rows
Threshold Bit Score: 1e+06
Threshold Setting Gi: 126660
Created: 11-May-2020
Updated: 6-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
P19401  34 VAGQTVRADHSDLVAEKQRLE 54  Streptococcus pyogenes
Q55312 193 QASREVSAKQQELAAAQLQLE 213 Streptococcus sp.
P02977 145 DLTKELNKTRQELANKQQESK 165 Streptococcus pyogenes serotype M5
Q54841 132 QNKREIDKRYKEQLHKQQQLE 152 Streptococcus pyogenes
P50468 134 QSQREVEKRYQEQLQKQQQLE 154 Streptococcus pyogenes
P19401 409 EEKQISDASRQGLRRDLDASR 429 Streptococcus pyogenes
Q54718 144 SHIQALESQTQDLESQTQALE 164 Streptococcus pyogenes
Q54718  81 TQKQALESQKQALESQKQALE 101 Streptococcus pyogenes
Q54718 165 SQKQALESRKQALEEQNKQLS 185 Streptococcus pyogenes
P12379 288 AEKAALEAEKADLEHQSQVLN 308 Streptococcus pyogenes
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