Conserved Protein Domain Family
Latrophilin

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pfam02354: Latrophilin 
Latrophilin Cytoplasmic C-terminal region
This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin family of G-protein coupled receptors that are involved in secretion. Latrophilin mRNA is present only in neuronal tissue. Lactrophillin interacts with G-alpha O.
Statistics
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PSSM-Id: 426735
Aligned: 10 rows
Threshold Bit Score: 430.826
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021330394 1105 RHSYCCSRTST-TSSHGSLKNSALRTNNRYYTGSqtrhaavhrQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMG 1183 zebrafish
XP_016846885 1110 RHASCCLRSPP-GATLGSLKTSAIRSNNRYYTGT---------QSRIRRMWNDTVRKQTESSFMAGDLNSTPTLNRGTMG 1179 green anole
O88917       1151 RHIHQVS-----LGPRGRSALPESQKDPGGQSGPgdpltfglcPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMG 1225 Norway rat
2_pfamImport    1 R-THCCSGKSVeTSISSSSKTTTSRTPGRYSTGS---------QSRIRRMWNDTVRKQ-ESSFITGDINSSATLNRGAMA 69  
XP_005170999 1123 R-THCCSGKSVeSTISTSTKTSTARTPGRYSTNS---------QSRIRRMWNDTVRKQSESSFITADMNSSATLNRGTMA 1192 zebrafish
1_pfamImport    1 RHTYCCGGLTAtESSHGSAKTSATRTSARYSSGT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQG--- 68  
XP_021322317  535 RQSQCCRTHPS-EGPHSVNKSSASRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 604  zebrafish
3_pfamImport    1 RQSQCCGALPS-EGSHSSAKTATSRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 70  
5_pfamImport    1 RQSQCCGALPA-EGPHAAAKAATSRSTARYSSAT---------QSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTG 70  
4_pfamImport    1 RHSYCCSRTSN-ANSHGSLKTSAMRTNNRYYTGSqarhgsahrQSRIRRMWNDTVRKQTESSFMAGDINSTPSLNRATMG 79  
XP_021330394 1184 NHLLTNPVLQTRTGSSPYNTLLAET--FTPPSPGVFNSTGtfrdpKSTLSKN-RDHGGMETLPLNGNFNNSYSLRSVGGS 1260 zebrafish
XP_016846885 1180 NHLLTNPVLQTRGGTSPYNTLIAESvgFNPASPPVFNSPGsfresKHPLNNS-RDACGMDTLPLNGNFNNSYSLRSGDFS 1258 green anole
O88917       1226 NHLLTNPVLQPRGGTSPYNTLIAESvgFNPSSPPVFNSPGsyrepKHPLG-G-REACGMDTLPLNGNFNNSYSLRSGDFP 1303 Norway rat
2_pfamImport   70 NHLITNALLRPHGTNNPYNTLLGDSavYNNPAVGMYNTQE------GILNNA-RDSSVMDTLPLNGNHANNYSMASSEYL 142 
XP_005170999 1193 NHLISNALLRPHGT-NPYNTLLGESavYNNPTANMFNTQE------GILNNA-RDSSVMDTLPLNGNHGNSYGVAAGDYL 1264 zebrafish
1_pfamImport   69 ----------------------------------------------HSMNNAvRDTSAMDTLPLNGNFNNSYSLRNGDFD 102 
XP_021322317  605 NYLLTNPLLRPHDTNNRYNNLLAETivCSTPSPPAFHSPG-----QRSLSNS-RDVSTMDTLPLNDNFNNSYSLREDDYE 678  zebrafish
3_pfamImport   71 NYLLTNPLLRTHDT-NPYNNLLAETvvCNTPSPPAFHSPG-------SLSNS-RDISAMDTLPLNGNFNNSYSLRDDDYE 141 
5_pfamImport   71 NYLLTNPLLRTHDT-NPYNNLLAETvvCNTPSPPAFHSPG-----QHSLSNS-RDISAMDTLPLNGNFNNSYSLRDDTYE 143 
4_pfamImport   80 NHLLTNPVLQTRSGTSPYNTLLAESvgFNPPSPNVFNSTGtfrdpKSTLSKS-RDTCGMETLPLNGNFNNSYSLRSVGPG 158 
XP_021330394 1261 gapggscdflgggggdspppllnPRGSETLGGi----RRNLSDaAAFEKMIISELVHNNLRGGGGVGGG---DRTCGSLA 1333 zebrafish
XP_016846885 1259 -----------------------ADGTKMADC-----RRNLNDaAAFEKMIISELVHNNLRGGGSGVVKgggGSTETSNP 1310 green anole
O88917       1304 p----------------------GDGGPEPPR-----GRNLADaAAFEKMIISELVHNNLRGA----------------- 1339 Norway rat
2_pfamImport  143 sdc-----------------vqiLDRSAGYGT-----HSNHKE-TTLEKKILKELTSNYIPSYLNNHER---ATTERNHN 196 
XP_005170999 1265 ----------------------------TYSS-----RGSEPP-TTLEKKILKELTANYAPSYLNTQERqgkAHQGTLTN 1310 zebrafish
1_pfamImport  103 ------------------------ESVQVVDC-----GLSLDD-AAFEKMIISELVHNNLRYH----------HHHHTER 142 
XP_021322317  679 d----------------------PAITCPTGC-----EIRLDD-AAFEKMIISELVHNNLRPR--RNQS---SSKCQADR 725  zebrafish
3_pfamImport  142 a----------------------VGVRAPGDLg----GLNLDD-ATFEKLIISEIVHNNLRPRGAPKGR---DAPRERDR 191 
5_pfamImport  144 ----------------------------SVRAagdlgGLHLDD-VAFEKMIISEIVHNNLRPRGGPKGR---DHPREQER 191 
4_pfamImport  159 gaggcdflggd--ssggpppllnPRGTENLGG-----RRNLSDaAAFEKMIISELVHNNLRGG----------VERGGSL 221 
XP_021330394 1334 RGHGHLGMG--RAG----------GGVEPVIGMEDDEDfr---srEARQRTPQDVEL------LYKALEEPLLLQRAQSV 1392 zebrafish
XP_016846885 1311 PGPPPPPSVgaGGG----------GTNNEDDAIVPDAP-------SLTHEENMEIEL------MYKALEEPLLLQRAQSI 1367 green anole
O88917       1340 -------SGgaKGPppeppvppvpGVSEDEAG-------------GPGGADRAEIEL------LYKALEEPLLLPRAQSV 1393 Norway rat
2_pfamImport  197 LMNKLVNSS----------------SKEDNGPMVLDNPvaf--phEE----NLGLEI------IREESNAPLLPPRPPPP 248 
XP_005170999 1311 KLNNHLANGgvAGS----------SSIPKDDVMVLDNPgaf-hrhDD--GGGLSLEL------IREESQAPLLPPRPPPP 1371 zebrafish
1_pfamImport  143 APPKVTVVG---------------GRGSEGPSIVADASs------LVHVSDAVGLELh-----NQQDLEAPLIPQRTHSL 196 
XP_021322317  726 NSSPQENCAdiDE-----------GVGDRNECENAETDts----aMPLSSCHPAMELlllnpnHREALEVPLLPQRTHSL 790  zebrafish
3_pfamImport  192 VLPPQTRVTvdRGGg---------GSGSEDDAIVADHAdasspqrGSGRGGHATLELllh-phHKEVLEAPLLPQRTHSL 261 
5_pfamImport  192 APPPQTRLT-----------------------VVADHEaas-prrGSGRGGHATLELllh-phHKEVLEAPLLPQRTHSL 246 
4_pfamImport  222 AKGHHSSGQgaGGEsgq----ssrGGGGEEDAMVADAP-----------QENIDIEL------MYKALEEPLLLQRAQSI 280 
XP_021330394 1393 LYQS---------------DPDESESYTADLTESLGHSGhsaqsaagqghsgppDSP--ARDSLYTSITNLRDSP----- 1450 zebrafish
XP_016846885 1368 LYQS---------------DLEESESCTADLTEGGDGQA---------------PSP--NRDSLYTSMTNLRDSP----- 1410 green anole
O88917       1394 LYQS---------------DLDESESCTAEDGATSRPLS---------------SPP--GRDSLYASGANLRDSPs---- 1437 Norway rat
2_pfamImport  249 DSHPpppppphsfsrprriPQETSESFFPLLTNEHTDEHt--------------HSPn-HRDSLYTSMPVLTDLPdgqmn 313 
XP_005170999 1372 ENHAplhtft----ahrrlPQENSESFFPLLPNDTHSSHthtp-------rahtHSP--LRDSLYTSMPTLTDLP----- 1433 zebrafish
1_pfamImport  197 LYAPqkk----------vkTDGEVDTFVSQLTPTNPDDNl--------------ESP--NRDSLYTSMPNLRDSP----- 245 
XP_021322317  791 IYASqkv----------irPHKISRDTQQDEGEVKKEDD---------------SSPn-NRDSLYTSMPNLKDSD----- 839  zebrafish
3_pfamImport  262 LYSSqka---------prcLEGQSSHGSETVTAEEDMGS---------------HSPsnNRDSLYTSMPNLRDSP----- 312 
5_pfamImport  247 LYSAqkaprrl--egpggsEAVTAAETPAP------------------------SRP--NRDSLYTSMPNLRDSP----- 293 
4_pfamImport  281 LYQS---------------DPEESESYTAELTEGLDAQL---------------QSP--NRDSLYTSMTNLRDSP----- 323 
XP_021330394 1451 -YPDSSP-------EPLEVVPRSAQP-------------------------PEELYYSSgRPAIGSRGa--PMQTFYQAp 1495 zebrafish
XP_016846885 1411 -YPDSSP-------EAVGEVLPHAQA-------------------------INEIYYTN-RPALVPRN---QLQAYYQV- 1452 green anole
O88917       1438 -YPDSSP-------EGPNEALPPPPPap---------------------pgPPEIYYTSrPPALVARN---PLQGYYQV- 1484 Norway rat
2_pfamImport  314 gLTDGEE-------DSSGELQPCKSAta---------------------peLDDVYYKS-MPNLGSRNhlhELQSYYHM- 363 
XP_005170999 1434 ---HGTD-------DLINGLHDDEDEeeeedgeeeegselhlangkgvimeSDDVYYKS-MPNLGSRNhiqELESYYQM- 1501 zebrafish
1_pfamImport  246 -CPESSP-------DVVEDLSPTKESe------------------------SEDVYYKS-MPNLGAGH---QLQAYYQI- 288 
XP_021322317  840 ---LVIG-------EEENSPCSSAQSe------------------------TQEQCCKS-LPDLGDGT---PAMSYYQI- 880  zebrafish
3_pfamImport  313 -SPSASPyppeeeeEEEEELSPSPQSe------------------------SEDAYHKS-MPELGDAP---QPLSYYHI- 362 
5_pfamImport  294 ---SASPyp----pDGEQLASSSPRSe------------------------SEDAYHKS-MPELGDGP---QPLSYYHI- 337 
4_pfamImport  324 -YPDSSP-------EPLEVVPRSAQP-------------------------PEELYYGSgRPAMGSRG---QMQTFYQPq 367 
XP_021330394 1496 pRRPSTEAHPAP---E--APHSEG----DGQMQLVTSL 1524 zebrafish
XP_016846885 1453 -RRPSNDGYLVPgslE--NPAVEG----DGQMQLVTSL 1483 green anole
O88917       1485 -RRPSHEGYLAApslE--GPGPDG----DGQMQLVTSL 1515 Norway rat
2_pfamImport  364 -GRGGSDGYMVSgskDesDSSPEEp--pVDPSHLVTSL 398 
XP_005170999 1502 -GRGGSDGFIAPpekE--DSSPEEq--pPDPSQLVTSL 1534 zebrafish
1_pfamImport  289 -GQENHDGYIIPvtkE--DCITEGdv-rEGQMQLVTSL 322 
XP_021322317  881 ---------SASlslE--AESAND-----GQMQLITSL 902  zebrafish
3_pfamImport  363 -NRGTSDGCIIPpnnE--DCAHDGeapaDGQMQLITSL 397 
5_pfamImport  338 -NRGTSDGCIPPpggE--GCAQEGaepaDGQMQLITSL 372 
4_pfamImport  368 aRRPSGEGYLVQvgmE--PGMSEG----DGQMQLVTSL 399 
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