5MR4,6GL7,3FUB,6Q2O,6Q2S,5VZ4,5VZ4


Conserved Protein Domain Family
GDNF

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pfam02351: GDNF 
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GDNF/GAS1 domain
This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
Statistics
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PSSM-Id: 426734
Aligned: 122 rows
Threshold Bit Score: 35.5779
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MR4_C        161 CLDAAKACNLNDNCKKLRSSYISICNREI--SPTERC--NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QD--QAC 229  human
XP_792667      29 CTDARRACERDDFCSLGLIAIQHHCGNVDg-RSCEATpsGLVNCLMML------QDARIYRVFASCYCdpsspEF--AAC 99   purple sea ur...
EFP04327       29 CLHYRSICLRNGTCNQHLKRFQTTCGYEL--NVCSGTs--PSDCVYHL------HRIRASFPTKTCTCyeaigFS--QEC 96   Caenorhabditi...
EFX71354        5 CLLAHQLCAEDPSCKSIETVIQHICGPET--VACSTTt--VTKCQAGL-----RTLQAFPVFHPTCLCre-psVD--PDC 72   common water ...
XP_016836803   74 CLYARKLCAEHASCSAILEIIPRVCGPEL--VACSTMt--VTKCQAAL-----RSLQAFQYFKPTCLCre-phVE--REC 141  jewel wasp
XP_007485250  271 CLEAAQICIGDVICNKKLALYLKACSATG--RPCNL-----TQCQAAIRFFYQNIPFHIGQMLALCDCa---pAD--TPC 338  gray short-ta...
XP_023416938  198 CLEIMEACVGDVGCNAHLASYLKACSAQG--SLCDR-----DHCQTATQSFYQSVPLNVAQMLAFCDCa---pSD--TPC 265  domestic guin...
XP_008506029   26 CLEVAEACVGDVVCNAQLAPYLKACSANG--NLCDV-----KHCQAAIRFFYQNMPFNIAQMLAFCDCa---qSD--IPC 93   Przewalski's ...
ESO00667      167 CLWRRRWCSRESRCLESLATFRAECRENKntKRCLPNn--WSACHLSL-----ISLRKHSRDLLSCQCghfknQQlnKKC 239  Helobdella ro...
5VZ4_B         25 CLEVAEACVGDVVCNAQLASYLKACSANG--NPCD-----LKQCQAAIRFFYQNIPFNIAQMLAFCDCaq---sD--IPC 92   human
5MR4_C        230 AERRRQTILPSC 241  human
XP_792667     100 HHQQRLTISNPC 111  purple sea urchin
EFP04327       97 DFFRQVIWNHPC 108  Caenorhabditis remanei
EFX71354       73 NAFRDSLFDHPC 84   common water flea
XP_016836803  142 NKFRDFLFDHPC 153  jewel wasp
XP_007485250  339 QKSKDILHSKSC 350  gray short-tailed opossum
XP_023416938  266 QQSREALHSRRC 277  domestic guinea pig
XP_008506029   94 QQSKEALHSKPC 105  Przewalski's horse
ESO00667      240 HKFQQNLLSNAC 251  Helobdella robusta
5VZ4_B         93 QQSKEALHSKTC 104  human
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