1NKP


Conserved Protein Domain Family
Myc-LZ
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pfam02344: Myc-LZ 
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Myc leucine zipper domain
This family consists of the leucine zipper dimerization domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes. dimerization via the leucine zipper motif with other basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins such as Max is required for efficient DNA binding. The Myc-Max dimer is a transactivating complex activating expression of growth related genes promoting cell proliferation. The dimerization is facilitated via interdigitating leucine residues every 7th position of the alpha helix. Like charge repulsion of adjacent residues in this region perturbs the formation of homodimers with heterodimers being promoted by opposing charge attractions.
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Statistics
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PSSM-Id: 426732
Aligned: 167 rows
Threshold Bit Score: 28.0003
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1NKP_D         59 AEEQKLISEEDLLRKRREQLKHKLEQL 85  human
25_pfamImport   1 EDERRLLKMKDELRKRSRELKHRLERL 27 
XP_026169546  364 EDERRLLKMKDELRKRSRELKHRLERL 390 zig-zag eel
NP_001265781  342 GDERKLLTTKEELRKRSRELKRRLEQL 368 Japanese medaka
14_pfamImport   1 EDERRLLTMKDELRKRSRELKHTLQQL 27 
XP_022074371  336 EDESRLLTAKDELRKRSRELKHRLQQL 362 spiny chromis
XP_007233103  363 AEERRLLSVKEQLRRRCEHLKHRLEQL 389 Mexican tetra
28_pfamImport   1 SNEQRLITEKEKLRRKQEQLKHRLEQL 27 
KPP76005      358 MESQRLSAKKDKLRQRQEQLKLRLEQL 384 Asian bonytongue
XP_026204269  349 NEGHRLKTKKDKLRAKQEELKARLAQL 375 climbing perch
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