Conserved Protein Domain Family
B12-binding

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pfam02310: B12-binding 
B12 binding domain
This domain binds to B12 (adenosylcobamide), it is found in several enzymes, such as glutamate mutase, methionine synthase, and methylmalonyl-CoA mutase. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding.
Statistics
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PSSM-Id: 426713
Aligned: 85 rows
Threshold Bit Score: 46.9345
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Ppro_0920   2 ISANVTLYPYPVYPLGMSMVAAALSGA-GHEVQQLDYLQQErslESVLEEVKRFQPGMIGIsvrniDNVNLLNTEYYIHN 80  Pelobacter pro...
ABK77116       10 IKILVAKLGLDGHDRGALVLCRAFRDA-GMEVIYSGLFATP---ERVARMAEDEDVDAIALsl--lNGAHGTLFPRVVKA 83  Cenarchaeum sy...
WP_011878110    6 IKVLLAKVGLDNQDKEIRLLARSLKNQgGIKVIYTGLYCTL---EEIVQSALQEKVDLVGVsv--hNGSHNEIFPRLRGL 80  Desulfotomacul...
jgi:Noca_2128  37 IRIMLAKIGLDGHDRGVKVVARTLRDA-GMEVVYTGLHRSP---EQVLEAAVQEDVDVLGIsl--lSGAHLTIFGRLFTL 110 Nocardioides s...
Q9L1X6          6 MRVVVAKPGLDGHDRGAKVVARALRDA-GVEVIYTGLHQTP---AQIVATAIQEDADGIGLsv--lSGAHMTAFTEVMKL 79  Streptomyces c...
A7IQE6          9 LRVLVTKIGLDGHDRGSRIVAAYLRDA-GMEVIYTPPWQTI---PGVVKLATEEDVDVIGIss--lATDHL-IVPKMMEA 81  Xanthobacter a...
Q0KAC1        561 PRILVAKLGQDGHDRGAKAVAAGLADA-GFVVELTPLFQSA---EAVVSAACDGDFDAIGIst--lGGAHLDLLPALLHA 634 Cupriavidus ne...
WP_012507934  584 pRIMVSKVGQDGHDRGAKVIAAGFADV-GFDVDISPLFQTP---EEVVQQALDNDVHLIGIss--lAAGHKTLIPKIIEE 657 Pelodictyon ph...
WP_011754273   18 KRVLMAKTSLDGHWRGINVVSRALRDA-GYEVILAGMINA----DTIARVAGDEDVDLIGLn----VGGRVEVVERILDT 88  unclassified N...
Q743B1          3 vRILVAKPGLDGHDRGAKIVARTLRDA-GFEVIYTGIRQRI---EDIASIAVQEDVAVVGLsi--lSGTHLALTARTVEA 76  Mycobacterium ...
jgi:Ppro_0920  81 vknmvdAIRTVSDARIVLGGAGFSLIPEQILEE--TGADFGVIGEGEQLMVAFA 132 Pelobacter propionicus DSM 2379
ABK77116       84 v-----EKKGLKDVLIVGGGIIPEVDIKK---LekAG-IDGVFGPGTTL-PEVI 127 Cenarchaeum symbiosum A
WP_011878110   81 l-----DAKKASDILVFGGGMIPEKHRQE---LkaSGVVDEIFGPSTSI-SIIV 125 Desulfotomaculum reducens
jgi:Noca_2128 111 i----aDLPYTPRFAVVAGGVMPDEDERT---LieLG-VAAVLGQDTAP-RHIV 155 Nocardioides sp. JS614
Q9L1X6         80 i-----QLEEATNIIVFGGGIIPDDDAAN---LleGG-VAALFTPGTSM-ATVV 123 Streptomyces coelicolor
A7IQE6         82 l-----RAAGLGHVGVVVGGIVPEAEQSA---LaaAG-VSRVFGPGAAR-EEIV 125 Xanthobacter autotrophicus Py2
Q0KAC1        635 ------LRQRALEVPVFVGGIVPADHRRL---LrqCG-VQGIFGPGTPM-EIIV 677 Cupriavidus necator H16
WP_012507934  658 l-----KAHNREDILVIAGGIIPEKDHAFLYE---KG-VAGIFGPGTVIAEAAi 702 Pelodictyon phaeoclathratiforme
WP_011754273   89 ------LASEAITVPVFAGGTIPHYAADR---LaaRG--VECFPPG-STLEAIV 130 unclassified Nocardioides
Q743B1         77 l-----RACDAADIAVVVGGTIPHADVPKLLA---AG-AAAVFPTGTpldklvr 121 Mycobacterium avium subsp. paratuberculosis
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