1N7Q,1HM3,2WCO


Conserved Protein Domain Family
Lyase_8

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pfam02278: Lyase_8 
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Polysaccharide lyase family 8, super-sandwich domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Statistics
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PSSM-Id: 426695
Aligned: 75 rows
Threshold Bit Score: 189.792
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1N7Q_A              375 LSAFNKMDKTAMYNAekG--FGFGLSLFSSRTLNYE-HMNKENKRGWYTSDGMFYLYNGdlSHYSdGYWPTVNPYKMPGT 451  Strepto...
jgi:Phep_2840       572 TDAFWVNEFLVHRRGenEkpFYVSLKLKSKRTVGAE--DFGNIRRSWYAGYGILPLKISg-DEYSdKVLANLDWHALPGL 648  Pedobac...
CDB11486            430 vrWFYNNDDLMKKTP--D--YHICINMASRRTDGLEsAAFADN-YNFYPTDGATLFQRDg-DEYF-RVMGGWDVTAMPGV 502  Bactero...
CDA75452            425 vRWFFNNDDLMKKTP--D--YHININMASYRTDGLEsAAFADN-YNFYPTDGATLFQRSg-DEYF-HIMGGWDITAMPGV 497  Bactero...
ESK88903            390 nrFFYVNDYMVHRGE--N--YLSTVKMFSTRTQNTEc-TNSQNPLGFHLADGVHYNYIVg-DEYE-DIAASWNWNLIPGI 462  Monilio...
XP_001873208        432 nNMFYDNDYMVHRGR--N--YVSTLKMYSSRTQNTEc-TNLQNPFGFHLSDGVLYTYLRg-NEYE-DISAAWDWNLIPGI 504  Laccari...
WGS:AACS:CC1G_06734 351 TRMFFANDYMVHRGP--N--FFSSLKMYSSRTLNTEc-INSQNPLGFHLSDGTLYTYLRg-NEYT-DISAAWDWDLIPGT 423  Coprino...
EGN94568            380 NRMFYSSDYMVQRGG--G--YVTTLKMKAKRIGNSEc-VNAQSPYGFHLSDGTVYNYLQg-NEYE-DIAAAWDWNLIPGI 452  Serpula...
XP_001747490        390 HRHFYDSDYTIMRGD--G--FQYSIRMYSARTVNAR-CVNDEGKQSQFTANGMVALYYTg-YDYD-SIFPTWNWQQLPGT 462  Monosig...
EDQ84702            308 HRHFFNSDYAIMRGE--N--FQYSIHMFSARTANAM-CVNTESKRSQFTASGMVARYYTg-DEYE-SVFPTWNWQQLPGT 380  Monosig...
1N7Q_A              452 TETDAKRADS----DTGkvlPSAFVGTSKlDdANATATMDFTNWN-----------------------QTLTAHKSWFML 504  Strepto...
jgi:Phep_2840       649 TEEWRSDAIpv-ghAQAslpGDNEVAGVTsDgRSGVAIYHHLPREty---------------------ssATALKSYFFI 706  Pedobac...
CDB11486            503 TAREGMDKLVpvtnWRGycsKYNFAAGATdSgENGVAGYIFEKMHgadkenvndk---gdrnvensllYGFKAYKGYFIL 579  Bactero...
CDA75452            498 TAREGMEKLQpvtnWRGycsKHNFAAGATdGsENGVAGIVFEKMNgsdkkavndkgdadkngiknellYGFKAYKGYFIL 577  Bactero...
ESK88903            463 TVDYGATALScdrt--gftgIEKFVGGVS-DgKIGLAAMRYTNPFtr----------------------sLRFQKVWFFL 517  Monilio...
XP_001873208        505 TVDYGATPLNcdgt--aasgVEAFVGGVS-TgQVGVAAMRYTNPNtt----------------------aLHWQKAWFFL 559  Laccari...
WGS:AACS:CC1G_06734 424 TVDYRNTLLHcsga--tvtgRESFVGGLS-DgKTGIAAMRYTNPTtr----------------------sLRWQKTWFFL 478  Coprino...
EGN94568            453 TVDYGATTLGcstt--krtgDQSLVGGAS-DgNIGVAAMRYENPLtk----------------------sLNWRKTWFFL 507  Serpula...
XP_001747490        463 LLDQLPTAPScgtt--twqtNTEEVGGVS-NgKLGAAFMAQHQF------------------------RPMSCVRSWGMF 515  Monosig...
EDQ84702            381 LLDQQDEAPNcstt--lmsaHTSEVGGVS-NgVLGAAFMTQRAR------------------------RPLKCVRSWAMY 433  Monosig...
1N7Q_A              505 KDKIAFLGSNIQNTSTDt---AATTIDQRKLESs-------nPYKVyVNdkeaSLTEQEKDYPETQSvflessdskkniG 574  Strepto...
jgi:Phep_2840       707 ADKIIALGNNIKRLRPGqqkeIVTTLDQSAFTQpltiaqngkTEVVqPG----QSVNLSFEADKPVWlhi------gnkG 776  Pedobac...
CDB11486            580 GDYFVALGAGVTNMNPDeeghIRTTLDQTALTGevfitrngkKEVLgK-----GETTLEGNKKKAIWltqq-----gkfS 649  Bactero...
CDA75452            578 GDYFVALGAGVTNMTPNiegdIRTTIDQTSLVNntyilnkgkKHVLsLG----DEVELKSNKSNPVWlvqe-----gkfA 648  Bactero...
ESK88903            518 DGDVQHVIISNIGSNTTs--pVYSVLDQRRHSGsvyvnseqlQLQ--------ENQVTNVTNVTSLWhg--------gvG 579  Monilio...
XP_001873208        560 QDDVQHVMVSGVASSSGa--pVYSVLDQRLHNGsimv-------------dgsAQRQSNSTTALSLWhg--------dvG 616  Laccari...
WGS:AACS:CC1G_06734 479 NDGAQHVVINILASSSGa--pVYSVLDQKRRNGltvv------------drreVLNSSTITGPQRLWhd--------nvG 536  Coprino...
EGN94568            508 DNDVQYVMVAQITSTTQa--pVFSVLDQRKLNGqvyvessttKGV--------VGGSGNFTQVSSLWhg--------gmG 569  Serpula...
XP_001747490        516 PDALIATAHSITAPDDIa--sVFTLADRRAASTvtialhngtHLTLa------ADQLISLPAAEVAWvhh------dntL 581  Monosig...
EDQ84702            434 PDALFATAHRISVPDKVp--vVFTLEDARARSTvtvalkngdQLEIa------SHRPIRLAADTVAWihh------dktL 499  Monosig...
1N7Q_A              575 YF-FFKK-S---SISMSKA----LQKGAWKDINegQSDKE----VENEFLTISQAH--KQn-GDSYGYMLIPNV 632  Streptococcus...
jgi:Phep_2840       777 YIiYP-------DGKQKII----VKTGTEINIT--DPANA----SKTPGYIIAVNHgqEPatGNGYSYFLVPNV 833  Pedobacter he...
CDB11486            650 YCiLPEYtS---KAFVACE----TRPTNWLKLNp-SNKKTanlpEQVQILRIWADHgqQPv-NDTYGYAVYTGq 714  Bacteroides s...
CDA75452            649 YTlLPKYtD---KAKVSCE----MKPTDWKKMNp-SNKNTdkmsKEVKILRLWVNHgqTPv-NDVYGYAVYTGk 713  Bacteroides s...
ESK88903            580 YT-F--NaSapfSLSLDVG----PKTGNWATIGt-SKQPP----ATVDLFAAWLQHtsLSs---PLAYSVYPGT 638  Moniliophthor...
XP_001873208        617 YS-F----PkpaSLSVQFG----NKTGNWSSIGt-STQPA----SAVDLFAAWIQHtsLNt---SIEYTTFPGT 673  Laccaria bico...
WGS:AACS:CC1G_06734 537 YA-FRSLtNattPLHVRMG----ERTGSWSAIGt-STQPP----VSVDMWAGLLEHidLSq---PLEYTILPGT 597  Coprinopsis c...
EGN94568            570 YS-F-DSsNaatKLSLSVG----PRSGSWSSIGi-SKQPS----STVDLFAAWLYHdnISa---PVSYAVYPAT 629  Serpula lacry...
XP_001747490        582 YA-LSNElG---PVHGTLAifcgNSTGNWIDIGv-TNRTE----TVDRFFAKWQl--pTPt-PHSAGYLMVPAV 643  Monosiga brev...
EDQ84702            500 YA-LSSKfG---PVDGTLEifrgWANGSWLDIGt-DPRPE----TVDRFFLKWVf--pKPa-PSSAGYLMIPSV 561  Monosiga brev...
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