6QTI,4O9U


Conserved Protein Domain Family
PNTB

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pfam02233: PNTB 
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NAD(P) transhydrogenase beta subunit
This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.
Statistics
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PSSM-Id: 426670
Aligned: 270 rows
Threshold Bit Score: 469.233
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QTI_A                    622 IMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATlggl---kpcpELLAQ-MSG--AMALGGtIGLTIAKRIQ 695  
EGJ72464                    8 IICAVLSIMVLIGISKMSKVETATNGNRLSALSLFLGVILTlvyydi------fdvgfIYI--CILIGSiIGYFFAKRIK 79   B...
Q7MUZ0                      8 ILCVLLSLMVLGGISMMSRVKTAVMGNTLSAVAMLGGIILTlvynei------lpawsVYI--FLIIGAgIGWTMAQRVK 79   P...
WP_013760370               14 VICAVLSILVLVGIAMMSKVKTAARGNALSATAMGLGVLVTllklq--------vvtfPWLigGILIGGiIGVLLYTRVK 85   P...
SLUandSVAtrep:TPE_1736      8 IICTVLSLGVLLGINMMSKVKTAVNGNRFSAVCMLIAVCVTlykyni------fssafMWI--GLGLGTlIGIILTIKAE 79   T...
Q73NG4                      8 IICGVLSIGVLLGINMMSKVKSAVKGNRLSALCMLAAVCVTlykyni------fsagmMWA--GLAIGAaIGIYLTIKVE 79   T...
CDD09056                  165 AMAIVLSLGVLLGIAMMGKVAYSKIGNRFSAICMLLAIILIivygngtshiaAVWT--LYI--GLALGTvAGIVLAKKVK 240  C...
bcmhgsc:HMPREF0573_10225   20 AVSVVLVILVLAGLNMLSRVQTAVRGNLLGALAMALAIVATlwnfgi------lsaveLYA--AMLVGSlFGVIIWRKTQ 91   M...
WP_012623827                8 iiagilvAAVLFGLRLMNKVPTAVRGNLFCASAMGLAILVTmfkdgs------laspaLWL--AIAVGMtLGLTLSNKVK 79   D...
XP_004030586               57 ASYFAASFLFIMSIISLNSFQNSRKSVLFAIGGMITAISATfyqesw----nladsFrWLS--SFLIGGsIGLYFGLNTK 130  I...
6QTI_A                    696 ISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHfaTDA-----AANLTKIVAYLGTYIGGVTFSGSLVAYGKLQGI-LKS 769  
EGJ72464                   80 MIQMPQLVALLNGIGGAASAFVGILSYVRIGST--PSE-----YENFTSVTAVLAIVVGLVTLVGSLVAAGKLHKV-LPQ 151  B...
Q7MUZ0                     80 MIQMPQMVALLNGVGGAASALVGILSLAAIGIN--PNNntaadYPIFSQATGMLALTVGMITLIGSLIAAGKLHKL-LPQ 156  P...
WP_013760370               86 MIQMPQMVALLNGIGGGASALVGALTLFQLPVS--N--------VYFTLVTAFLAIIIGMLTLVGSLVAAGKLHRV-LPQ 154  P...
SLUandSVAtrep:TPE_1736     80 MITMPQTVALLNGLGGAASAVAALLTLAAIDGK--T--------TVFAIITGGIALAVGALTFSGSLIAAGKLHKL-LPQ 148  T...
Q73NG4                     80 MITMPQTVALLNGLGGAASAVAALLTLAAVNTQ--A--------GIFAIVTGGIALAVGALTFSGSLIAAGKLHKL-LPQ 148  T...
CDD09056                  241 MIQMPQMVALLNGLGGAASAIVGAFAMLGVGTG--F--------DAFSTTTSALALAVGMITLIGSLVAAGKLHKI-LPQ 309  C...
bcmhgsc:HMPREF0573_10225   92 MIRMPQTVALLNGLGGMASMLAGALALTGHADN--N---------AFAQFTAGLAIAVGGATFFGSLIAAGKLHQI-LDQ 159  M...
WP_012623827               80 MIQMPQMVAFLHGIGGGAAAIVSFLVLTDTGAP--S---------AFERGSACLALAMGMTTIAGSFVAAGKLHQI-LPQ 147  D...
XP_004030586              131 ITQYGQAVCFLQSLIGLASFLLGIAQFERLKQF--KAK-----FNKLDSFQTVFVCLLGTMIFSSAVTCYFKLDKKnIAK 203  I...
6QTI_A                    770 APLLL--PGRHLLNAGL-----LAASV--GGI---------------IPFmmdpsfttgitclGSVSALS----AVMGVT 821  
EGJ72464                  152 KPIVW--KNHQLLTTIF-----IIGSIvpVVGayfsqdssfffanpsFV-----------------LLLSiassCLFGLT 207  B...
Q7MUZ0                    157 RPVIW--PNHSMFTSLL-----LILTVgfVVLgsvsi---------------------egfplFWAIIGGlffsSLFGLF 208  P...
WP_013760370              155 KSVVW--PFHNVATSLT-----LVVAVffLLIgtlny-----vvpsaLIya-----------mIGTMLFS----ALFGLY 207  P...
SLUandSVAtrep:TPE_1736    149 KPIVL--PYHQALTVLT-----FLGMTafIVF---------------LPLkierls--iimlsFIGLAVS----FLFGVF 200  T...
Q73NG4                    149 KPTVL--PAHQALTTVS-----FLGMIafIVL---------------LPIkpelm----iiisVAGLVIS----LLFGIF 198  T...
CDD09056                  310 KPVVY--KGHQAMTVGSlcltlALIVVfaAIAalsgsgkialgidlkAFcgi---------miALLFVIA----GFFGYI 374  C...
bcmhgsc:HMPREF0573_10225  160 HPKVL--PAHSVWVGLS-----LLVSLgaALAyvfppfsspggaqtvLL--------------IVQIVAA----NLFGYL 214  M...
WP_012623827              148 KPVIL--PDHTKIIMAIlavmgFSVLMgtAFPqflf-----------------------gffiFLMFVTG----TAFGIG 198  D...
XP_004030586              204 EPLNLigKYRNSVNFIV-----LICIG--VFGll------------yVVFsmg-------falWMIFILA----LYIGWG 253  I...
6QTI_A                    822 LTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILG--GYg------ 893  
EGJ72464                  208 FAIRVGGADMPITISLLNSLSGVAGAIAGMAIGDILLVSVGGIVGASGLLLTQIMCRNMNRHLIDILLGktSAagk---- 283  B...
Q7MUZ0                    209 FSIRVGGADMPITISLLNSLSGVAGAIAGMAVGDILLVAVGGIVGASGLLLTQIMCRAMNRKLMSILMAsg--------- 279  P...
WP_013760370              208 FSIRVGGADMPITISLLNSLSGVAGAIAGMAIGDIFLVAVGGVVGASGLLLTQIMCRAMNRSLINILIPhgKa------- 280  P...
SLUandSVAtrep:TPE_1736    201 FAVRVGGADMPITISLLNSTSGVAASITGMAIGDILLVSVGGIVGASGLLLTQIMCRAMNRSLAAILFSka--------- 271  T...
Q73NG4                    199 FAIRVGGADMPITISLLNSTSGVAASIAGMAIGDILLVSVGGIVGASGLLLTQIMCRAMNRSLASILFSkaASpakpakp 278  T...
CDD09056                  375 FAIRVGGADMPITISLLNSLSGVAGAIAGLAINDLLLVAVGGIVGASGLLLTQIMCKAMNRKLGAILLGg---------- 444  C...
bcmhgsc:HMPREF0573_10225  215 LAVRVGGADMPITISLLNSLSGVAGAIAGLAISDLLLVAIGAIVGASGLLLTQIMCRAMNRHLMEILLGntSVstaaa-- 292  M...
WP_012623827              199 FTLRVGGADMPITISLLNSMGGVCAAIAGFAVNDPLLVAIGGIIGSSGYLLTRIMCRAMNRKLLSILLGesSVvt----- 273  D...
XP_004030586              254 LVVSVQQRQLNVIIPFQTVLMGITLSFVGFVFNRDYLIIVGALCITGGYKLTQRASHGINCGIFDAYFK--SW------- 324  I...
6QTI_A                    894 ----TTSTAGGKpmeiSG-----THT------EINLDN-----A----IDMIREANSIIITPGYGLCAAKAQYPIADLVK 949  
EGJ72464                  284 -pkaASSSKATVqsapQKtekkeETL----------------------SDIVSNAKEVILIPGYGMALAQAQHQVKQLAD 340  B...
Q7MUZ0                    280 ---aKATPAATTpttaSKqekgeVAApapakaEKTA------------GSVLRDAKRVIIVPGYGMALAQAQHQVRQLAD 344  P...
WP_013760370              281 ----KAPAKATApakaAApapkaPAApqpkqeSSPIDQ-----A----VAMLRGAKRVIIVPGYGMALAQAQQEVKQLAD 347  P...
SLUandSVAtrep:TPE_1736    272 ---sSPSKPIKQdqtsSEsltklEAQktedekPGSEKD-----I----GSWFGEAKDIIIIPGYGMALSQAQGLVKQLSD 339  T...
Q73NG4                    279 aqpaSPSESSSKeaseKQaqqtgEAKpaqqelTATGHA-----DksqlTSWFNDAKEIIVIPGYGMALSQAQGLVKQLAD 353  T...
CDD09056                  445 ----TSSNDNAQktapEKvevkaETKpaevkkEVKAEEkpvvkTeinyAATLNNAKEVIIVPGYGMAIAQAQHLVKQLAD 520  C...
bcmhgsc:HMPREF0573_10225  293 tpteTESEKPDDsacaGEtdtseTTRgdrptlAAPVAD-----PentfADWVENAQRVILVPGYGMALSQAQAQVKRLLD 367  M...
WP_012623827              274 --psAPAKKAAPaaraAAparsvESE-----------------A----AKLVQNARNVVIVPGYGMALAQAQYKVKQLAD 330  D...
XP_004030586              325 ------NDQNIEiksnISsdfayNNQ------DINFMD-----L----SNELMSASNIVFVPGNGIYQQQCTKYIADIAL 383  I...
6QTI_A                    950 MLSEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINhDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPV 1029 
EGJ72464                  341 KLEKNGAKVRFAVHPVAGRMPGHMNVLLAEADVPYDELYEMEQINdDFKKTDLVIVIGANDVVNPAAREAEGTPIYGMPV 420  B...
Q7MUZ0                    345 KLTANGTEVRYAIHPVAGRMPGHMNVLLCEADVPYDQLFEMDAINgDFAQTDAVVVIGANDVMNPAARNAEGTPIYGMPV 424  P...
WP_013760370              348 KLARGGADVKYAIHPVAGRMPGHMNVLLAEANVDYDSLYEMEAINdQFANTDAVIVIGANDVLNPAARNAEGTPIYGMPV 427  P...
SLUandSVAtrep:TPE_1736    340 KLEGMGKTVRFAIHPVAGRMPGHMNVLLCEVDIPYDKLYEMETINgEFEKADLAVIIGASDVVNPAANTAEGTPIYGMPV 419  T...
Q73NG4                    354 KLESMGKNVRFAIHPVAGRMPGHMNVLLCEVDIPYDKLYEMEAINpDFDKTDLAIIIGASDVVNPAANTAEGTPIYGMPV 433  T...
CDD09056                  521 KLTANGTKVKYAIHPVAGRMPGHMNVLLCEANVEYEDLFEMDDINpEFKTADATIVIGANDVLNPAANTAEGTPIYGMPV 600  C...
bcmhgsc:HMPREF0573_10225  368 YLEKSGKTVDFAIHPVAGRMPGHMNVLLAEVDVDYEKLREMKDINdDFASADLTVVIGANDVMNPAANTAEGTPIYGMPV 447  M...
WP_012623827              331 LLESRGAKVSYGIHPVAGRMPGHMNVLLAEANVDYEHLLEMDTVNpMFAESDLVIVVGANDVVNPAANTAEGTPIYGMPI 410  D...
XP_004030586              384 YLQEAGKNIQFCIHPSSGKLPGHMNAILAEYDVAFEIIKELEEVD--FSKFELCIIVGAYDEINPDFYN-----FQKIPT 456  I...
6QTI_A                   1030 LEVWKSKQVIVMKRSLGVGYAAVDNPIFYK-----PNTAMLLGDAKKTCDALQAK 1079 
EGJ72464                  421 LNADQAKNVIVCNYDTKPGYAGVENPLYKS-----NKTKMLLGDAKESLYKVLEA 470  Bacteroides coprosuis DSM ...
Q7MUZ0                    425 LNVDDAPEVIICNFDLKPGYAGVDNPLYTRa----TGVFLKLGDAKESLAEIMKE 475  Porphyromonas gingivalis
WP_013760370              428 LNVDQAKQVIICNFDLKPGYAGVENPLYSRg----EGVALCLGDAKATIDQILSg 478  Porphyromonas asaccharolytica
SLUandSVAtrep:TPE_1736    420 LAADKAKKLVICNFDLQPGYAGVPNPLYEPn----ENIMLLLGDAKDSIAKILKS 470  Treponema pedis str. T A4
Q73NG4                    434 LAAEKAKKLIICNFDLQPGYAGVPNPLYEPn----PNTMMLLGDAKDSINTMLDs 484  Treponema denticola
CDD09056                  601 LDVADCKNIFIFNYDLKPGYAGVDNPIYTRe----NGVHLYLGNAQETLQKFIAd 651  Clostridium sp. CAG:349
bcmhgsc:HMPREF0573_10225  448 LNVGDCAHVAIFNFDLKPGYAGVENPLYARaetepERVLIFPGDAKETLAarlda 502  Mobiluncus curtisii ATCC 4...
WP_012623827              411 LKADEAKNIIIANYDDKPGYAGVPNPLYGR-----DGVILMTGDAGKTFDRLLay 460  Desulfovibrio desulfuricans
XP_004030586              457 CQVWESNRVVYIQTKVE---NNKNNGVFDY-----NNVFVLKGDNQKNLEAVYNQ 503  Ichthyophthirius multifiliis
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