2AG9,6R4M,1NEP


Conserved Protein Domain Family
E1_DerP2_DerF2
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pfam02221: E1_DerP2_DerF2 
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ML domain
ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.
Links
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Statistics
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PSSM-Id: 426667
Aligned: 76 rows
Threshold Bit Score: 65.0856
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AG9_B                5 FSWDNC---DegkDPAVI-RSLTLE----PD---PIVVPGNVTLSVVGsTSVPLSSPLKVdlVLEKEVaGlwIKIPCTdy 73  human
1NEP_A                3 VKFKDCg--Sw--V--GViKEVNVSpcptQPc--KLHRGQSYSVNVTF-TSNTQSQSSKA--VVHGIVmG--IPVPFP-- 67  cattle
Q9Z0J0               22 LHFKDCg--Sk--V--GViKEVNVSpcptDPc--QLHKGQSYSVNITF-TSGTQSQNSTA--LVHGILeG--IRVPFP-- 86  house mouse
Q28895               22 VHFKDCg--Sa--V--GViKELNVNpcpaQPc--KLHKGQSYSVNVTF-TSNIPSQSSKA--VVHGIVlG--VAVPFP-- 86  dog
WGS:AADE:GA20242-PA  18 LEFSDCg--Sk--T--GKfTRVVVEgcdtTKsecILRRNTTVSFSIDI-NLAEEATAVKT--VVHGKVlG--IEMPFP-- 84  Drosophi...
Q174K0               26 VQFENCg--De--NTIGNySLVEVSrcnlDEpacVLKRNTNATISITF-TSDEELPELKA--VVHGIIlG--MEVPFN-- 94  yellow f...
Q2F605               17 KFFKDCg--Sk--L--ATvHNVTVSgceeSSshcILKRNTDATIGLQF-TPLHNIDRINT--EVHGVImN--IPIPFP-- 83  domestic...
Q9VFN7               21 TDVSQCp-kSk--SKALAaGDVSISncpkSKc--ILKRNTEASIQMKI-RPERDFQELTS--DIQGIIlD--VPLPFPg- 89  fruit fly
Q16N77               21 TEVKACpstKs--MVPISeNTIDISncvkGPc--KLKRKTNVSINQKF-TPSEDIKSLTT--TVFAQVlS--LPLPFIg- 90  yellow f...
Q7PR71               20 TVVESCgatRs--LVPIEqNTVDISncekGPc--RLKRRTTVSINQKF-TPTEDVKSLST--TVFAKIvG--LPLPFVg- 89  Anophele...

2AG9_B               74 igSCTfeHFCDVLdmliptgepcpeplrtyglPCHCPFKEGTY-S-LPKSEfvvpdleLPSWLTTG-NSRIE-SVLSSSg 149 human
1NEP_A               68 --IPEs-DGCKs--------------------GIRCPIEKDKTyNyVNKLP-------VKNEYPSI-KVVVEwELTDDKn 116 cattle
Q9Z0J0               87 --IPEp-DGCKs--------------------GINCPIQKDKVySyLNKLP-------VKNEYPSI-KLVVEwKLEDDKk 135 house mouse
Q28895               87 --IPEa-DGCKs--------------------GINCPIQKDKTySyLNKLP-------VKNEYPSI-KLVVQwMLLGDNn 135 dog
WGS:AADE:GA20242-PA  85 --LANp-NACVNs-------------------GLKCPLEKGESyRyTATLP-------VLKTYPKV-AVLVKwELQDQNs 134 Drosophi...
Q174K0               95 --LPNp-NGCKDs-------------------GLECPLAPDTEhKySTTLP-------VLKQYPKV-AVEVKwELKSGDk 144 yellow f...
Q2F605               84 --LPEs-DACKDn-------------------GLTCPLKEGTLaDyKATLP-------ILKSYPKV-TVEVKwELQSEHg 133 domestic...
Q9VFN7               90 --YYGt-SACPHIydea-----------gekkV-GCPLKAGQVyTyKNSFK-------ILPVYPTV-SLEIHwGLGDKH- 145 fruit fly
Q16N77               91 --VDGt-SACDYIfaed-----------getkL-GCPLKAGVPvVyKRSFP-------VLEIYPKM-SLTVHwELQGRGs 147 yellow f...
Q7PR71               90 --VDGt-SACPYLfaed-----------getkL-ECPLKAGVPvVyKRSFD-------VLEIYPKIpSMTIHwELQTKSg 147 Anophele...

2AG9_B              150 KRLGCIKIAASL 161 human
1NEP_A              117 QRFFCWQIPIEV 128 cattle
Q9Z0J0              136 NNLFCWEIPVQI 147 house mouse
Q28895              136 QHLFCWEIPVQI 147 dog
WGS:AADE:GA20242-PA 135 DDIICVEIPAKI 146 Drosophila pseudoobscura pseudoobscura
Q174K0              145 -DVICVKIPAKI 155 yellow fever mosquito
Q2F605              134 -DLVCVLINAKL 144 domestic silkworm
Q9VFN7              146 GDAACFQIPAKI 157 fruit fly
Q16N77              148 KSVTCFEVPAKI 159 yellow fever mosquito
Q7PR71              148 RSITCFEVPAKI 159 Anopheles gambiae str. PEST
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