4JFN


Conserved Protein Domain Family
APP_N

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pfam02177: APP_N 
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Amyloid A4 N-terminal heparin-binding
This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. this region is also responsible for stimulation of neurite outgrowth. The structure reveals both a highly charged basic surface that may interact with glycosaminoglycans in the brain and an abutting hydrophobic surface that is proposed to play an important functional role such as in dimerization or ligand-binding. Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo.
Statistics
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PSSM-Id: 460474
Aligned: 22 rows
Threshold Bit Score: 159.776
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JFN_A                9 EPQIAMFCGRL------------NMHMNvQNGKWDSDPSGT---KTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQ 73 
EDO45291             31 EPLVAMWCGKV------------NQHMDiNTGEWATDENGH---SMCSTSTKQVLKYCQHVYPKLNVSNVVEANMNVTIK 95 
EEN69130              1 -PMVAMVKDKM------------NQHINlDSGKWETDPTGK---HGFKDKPQDILDYCKMMYPNLEITNIEEHTKEIKIE 64 
XP_002111682         29 VLRVTFNCNKV------------PKYYDlVSKDFVDDKSGI---AQCPKNKTEILDYCRKVYKDYDIVNIVHENMYQHFN 93 
CAP33080             35 IPMVAFSCGYR------------NQYMT-EEGTWKTDDERY---ATCFSGKLDILKYCRKAYPTMNITNIVEYSHEVSIS 98 
XP_002400743         11 QPMVALLCGHGri---------nNQYLA-EGQRWVSDPDPK---AVCSKDKLSILEYCRKVYPKRDIRNIVESSRYYHVD 77 
XP_015791357         51 QPMVAMLCGRGkf---------hNQYLD-ENKRWVSDPDPK---AVCTKDKLEILEYCRKVYPKKDIRNIVEYSKYMVVD 117
XP_002426949         17 EPQVAILCESGsgseqqktqayhSQYMT-EQGKWITDINNK---ATCLKDKMDILDYCKKVYPKRDVTNIVEASHYLKVP 92 
XP_005330630         53 SAQVAGLCGRL------------TLHRDlRTGRWEPDPQRS---RRCLRDPQRVLEYCRQMYPELHIARVEQAAQAIPME 117
WGS:AANI:GJ19504-PA  32 EPQIAVLCEAGqi--------yqPQYLS-EEGRWVTDLSKKttgATCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIG 102
4JFN_A               74 NWCKR---GRKQCKTHpH-FVIPYRCLVGEFVSDALLVPD 109
EDO45291             96 TWCDP---KNVNCNAT-K-TVLPYRCLVGKFEADALLVPP 130
EEN69130             65 NWCKPg--STAPCGGH-PhKVRPFRCLVGRFESDALMVPT 101
XP_002111682         94 NWCDN---ERKMCYFS-G-TSRVYRCVVGLFFGHAVSVPE 128
CAP33080             99 DWCRE---EGSPCKWT-H-SVRPYHCIDGEFHSEALQVPH 133
XP_002400743         78 GWCKVg-qRGRSCRGS-H-WVKPYRCLEGDFQSDALLVPE 114
XP_015791357        118 NWCKFg----qKCGGR-H-LVKPYRCLEGPFQSDALLVPA 151
XP_002426949         93 NWCKVg-hK--KCKIS-R-WVKPFRCLEGPFQSDALLVPE 127
XP_005330630        118 RWCEGa--RGGHCAHP-HhQVVPFRCLPGEFVSEALLVPE 154
WGS:AANI:GJ19504-PA 103 GWCRQgslNAAKCKGA-HrWIKPFRCLEGPFQSDALLVPE 141
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