6EZN


Conserved Protein Domain Family
DAD
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pfam02109: DAD 
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DAD family
Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.
Links
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Statistics
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PSSM-Id: 426606
Aligned: 105 rows
Threshold Bit Score: 83.3257
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6EZN_B                         24 QETFKTSKRAYFAQIekYPKLKLIDTFCFFLVLLGVIQCTFIILIrDNFPFNAFLAGFIICVGQFVLLMSLRLQLC--N- 100 Saccharomyces cerevisiae S288C...
A0EFY2                         13 LGIAASFWQQYSTKT--PQKLKIMDAFSLYCFILVIIQLFYCALV-GDFPRNSFLSGIFAAAGAMIINICLRKQLNpeTk 89  Paramecium tetraurelia...
XP_002808792                    2 NKILSTFYENYRN-T--PRNIKFVDIYILITLVNILLLYMYGYFS-CSFDEKISVAAIFTALGNLTFSIALREQIS--Nk 75  Plasmodium falciparum 3D7...
WGS:AAGF:cds.TTHERM_00411530A  37 RDIFRTFWNSYKKNT--PSKIKLMDAFVVYCIMIICIQFFYYFVV-GNFPQNSLIIGIFAPLGSATFTVCLRQQIS--Qk 111 Tetrahymena thermophila SB210...
XP_001327154                    7 SGILAELKEVYGKQ---KSHFRGLDIFALFGIMVALIQLVYSGLT-HGYPFCSMVSAVCMSLGFTVLVISLRLHLTpeIe 82  Trichomonas vaginalis G3...
WGS:AAFB:cds.EHI_103780A       18 ESFIKVLLTSYSKET--PSRLKMIDCFLIYQLITAALVLVYGFFF-CHNPLNAFLAALFSCAGMFVFTMSLRLHES---- 90  Entamoeba histolytica HM-1:IMSS...
ESS29091                       75 TCIVRDLARAYLQRY--PPRILMMDAFCACLLLMAGLLVLYAVLTrSTFPFNAFLSAFISCVGTAVLTVCFRIQIT--Nk 150 Toxoplasma gondii VEG...
EEA04882                       24 TEVFTEIMTSYLKVV--PKHIQIIDCFISYLAIITITQLIYCILIgMAYPLNSFIAGIFTSGGTALLVSALRIQLIap-- 99  Cryptosporidium muris RN66...
Q5CRL9                         47 LDVFQEMKQAYFSKV--PENIQILDSFILFMALISIIQIIYCLLIrTTYPIDSLIGGVFCTTGTALLVSALRIQLTcp-- 122 Cryptosporidium parvum...
WGS:AFWA:PNEG_00395            25 LESFYEFFNNYQNNT--DKSLKKIDYLIIFLVFSACIQLLYCILS-GSYPFNSFLSGFISTVGQFVLTVSLRGQFNikDe 101 Pneumocystis murina B123...

6EZN_B                        101 -SFPGISKNRAFAEFIVASLILHFVCLHFIN 130 Saccharomyces cerevisiae S288C
A0EFY2                         90 --YMEISNERAFWEYLAAMVVLFLTVINFLG 118 Paramecium tetraurelia
XP_002808792                   76 -sLFNIKREKIIFDFVLCSLVLYIGVFSYMh 105 Plasmodium falciparum 3D7
WGS:AAGF:cds.TTHERM_00411530A 112 tRYMNQSSDRSFWEYFLSMYIMFLACINYLG 142 Tetrahymena thermophila SB210
XP_001327154                   83 sS---ISNYRAFAEYIVALSLLFLFGWNFMN 110 Trichomonas vaginalis G3
WGS:AAFB:cds.EHI_103780A       91 ---EEGSSKKYFVEYVFCVILLQLSVANFLG 118 Entamoeba histolytica HM-1:IMSS
ESS29091                      151 sIFK-LTEERALADFLLCSLLLQVAVFTFIG 180 Toxoplasma gondii VEG
EEA04882                      100 elFDNISPKTAIFDFLICSFVF------FIG 124 Cryptosporidium muris RN66
Q5CRL9                        123 syFGDVSPKTAFTDFVICCIVF------FIG 147 Cryptosporidium parvum
WGS:AFWA:PNEG_00395           102 eNNENISPERAFGDFVFSSLILHFFVITFLG 132 Pneumocystis murina B123
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