3NEK


Conserved Protein Domain Family
DUF128
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pfam01995: DUF128 
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Domain of unknown function DUF128
This archaebacterial protein family has no known function. The domain is found duplicated in Methanothermobacter thermautotrophicus MTH_1569. Many of these are attached to an N-terminal winged helix domain suggesting these are transcriptional regulators and that this domain has a ligand binding function.
Links
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Statistics
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PSSM-Id: 426556
Aligned: 67 rows
Threshold Bit Score: 196.948
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3NEK_B           18 IKTALSKXFNAXAKVTYdideADGDVIVNTAFIdKKYLDEAFDILKEAYKKGLGISDRFGIVEENDR----------IKI 87  Methanocaldo...
jgi:Ferp_2332    83 iGYSISRVHECVFYSDFdvesGEGKVVANLAIFpREYLEEVLDMFYRCWKKGLTFSDKVIVDENIPFiee-----neVGL 157 Ferroglobus ...
jgi:Ferp_1130    85 IGSFIELREEYAYNANFdpfkRKGLVSLNIGIIrKRDLEKSLELIKACMDAKLAVSRFVKIYEREAGntki--pkgkVGI 162 Ferroglobus ...
WP_014807136     91 iglssmeTEILITKSDLdlcsNKGKAIVNITAVqEERFDEAVSILKEVSNSNIIVSPLVAFLEGGQRiwnyrvpeghRAI 170 Acetomicrobi...
CGB:Asulf_00884  87 lGEFSETLEYNMLHSTFniytMEGTVPTSVAILdKDQADRALEVLSEVLNSRLATSRYAVLLDEGEIagkteieegkIGI 166 Archaeoglobu...
CGB:Asulf_00277  81 lGEFSERVEYNVFMSNFsideFKGTIPTNIAILdKKHYEKAMTILNEVSQSRFIVSDLITVIDESERagyleipknkFAV 160 Archaeoglobu...
Q2FTS7           83 IGFVISKLERLAFRSTFdpatSTGDVAYNLTIVpDEILEPVSQMFDKVRDAGCSFFSGYSVIDRDPRvps-----ghTGI 157 Methanospiri...
WP_012616993     83 IGFIISKLERLAFRSTFnpitGTGDVAYNLSTIpEERVDEVTAAFDQVIDAGCGFFNAYRIIDRHPKvpa-----ghVGF 157 Methanosphae...
WP_015286615     83 IGFIISKLERLAYRSTFdpaaGTGDVAYNLSMVpNEHAEKVTTAFDEVIRAGCGFFNSYRIIDHDPRiph-----gyTGF 157 Methanoregul...
jgi:Mboo_0526    83 IGFVISKLERLAFRSTFdpatGTGDVAYNLSFVqKDDLDRALVAFDEVNRAGCGFFNSYRILDDDPRvps-----dcVGV 157 Methanoregul...

3NEK_B           88 QTICAVTLDGIFLRNSVPLIPKYGGILEITED-KERFIDIIGYDGSSLDPHEVFFNF--------------VDCEKTFLA 152 Methanocaldo...
jgi:Ferp_2332   158 YYISSFTLDAILYRNGIVSSPRFAGSIEISNFnFVRFTQVIGLEESSITALDLFIQRmysdkdeesisnllEKGEGEVYG 237 Ferroglobus ...
jgi:Ferp_1130   163 GLVSTSVVDAALIGSRISSFPTFAGILQYSDWkPLRFVHAISYYGSTLDPIDLFIRSgfcsv-----kdavERGNGNVPA 237 Ferroglobus ...
WP_014807136    171 LCLSSANYDVVLRRCGVHVETVATGLFRIQDHkYKGFADIISHSGTTLSPGELLVRGgftdv-----msavRTGRGYVTA 245 Acetomicrobi...
CGB:Asulf_00884 167 GTISSTVMDIIMLNIGVILSVEYAGLLKYENGlPVGVTELINYSGTTISPGLLFIRGgytsv-----ydvvVRGSGYAVI 241 Archaeoglobu...
CGB:Asulf_00277 161 GIVSNTIFDVILRKYGVVLTPEASGLLHVEKKvPQGFSELISYSGTTLSPGWLFVKSrltsv-----fraeKKGYGDVIA 235 Archaeoglobu...
Q2FTS7          158 LTVCSITMDGVFQHNGIPVKVAYGGTIQIEDKkPVRFMNIIGYQGSTVDSLQLFLGAgltsi-----nqyiNTGSGILLA 232 Methanospiri...
WP_012616993    158 ITLCSITMDGVFQQHGIPVKVAYGGTLAVENRkAIEFTNLIGYRGTTIDPLQLFISSgltai-----kplvTTRSGIALA 232 Methanosphae...
WP_015286615    158 ITICSISMDGVFQRQGIPVRMAYGGRLEIENGsPREFKDLIAYRGTTIDPLELFISAhltsi-----ssfaRSKSGITLA 232 Methanoregul...
jgi:Mboo_0526   158 ITLCSITMDGLFQRNGIPVKMAYGGRLEIENNvPQRFRDLIGYRGTTIDPLELFISSgltsi-----hdftRTKTGIALA 232 Methanoregul...

3NEK_B          153 GFREVHRVAREKLEEVlkkL---NWNGIKAIGEp--nNELYGIGVNK-DXCGVVTXGGINPLVLLKENEIPIELKAXHEV 226 Methanocaldo...
jgi:Ferp_2332   238 MYREIPFVAREKTIEIlekLkeyGISPLYVIGEl--dKSVCGIPPKGvNKVGLVCVGPSTPVGILRALKVPIRVHISSEI 315 Ferroglobus ...
jgi:Ferp_1130   238 DVREIPLVLRKRAVEIieqLekiGINGAVYVSGa--eNDALGIPVNN-YKAGVVVIAGSTPLVYLKEKGIDVEIKILAAF 314 Ferroglobus ...
WP_014807136    246 AIKTFPSFMYETVVEAiknCkndNISGLFELGYlmpqKYQMSIK-DR-TRGYMLVFGGANYFAPLVEWGITSALSIASGL 323 Acetomicrobi...
CGB:Asulf_00884 242 AIRNFSPYAIEEVEKEvqlAsarGLGKVLTITM----DRFFGIPAQ--KRAMLVFQAGINQLAPLYELGFKPVLEINSSL 315 Archaeoglobu...
CGB:Asulf_00277 236 TIRSFNVHLIDVVKRRvseIeekGIRGIISISYp--lENHIIQSIN--FKANLIIYAGVNYLAPLQEKGLNPEIHINEQL 311 Archaeoglobu...
Q2FTS7          233 NVRQIPGAAEERSQTLiqeMqacGFRFPLMMGK----GRIFNLLTDP-HRISLVSYSGMNSIGGAVEAGYKLKTEIGAGT 307 Methanospiri...
WP_012616993    233 NIRQVPLPAESQVSDLinaMrnnGFVLPVEMGQ-----TVFNVPPDP-HRISIVSYSGMNLIGNCVELGIPIKTEIGAGN 306 Methanosphae...
WP_015286615    233 NVREIPCAARSRAEETirqLnscGFVFPVTMGN-----HVFNLPPNP-YRLSIVAFSGLNYIGNTVEHGIPIKTEIGAGN 306 Methanoregul...
jgi:Mboo_0526   233 NVREVPRSAQGEIKQIirlMndcGFIYPVTMGN-----HIFNLPDSS-YRLSIVAYSGLNYIGNCVEQGIAIRTEIGAGN 306 Methanoregul...

3NEK_B          227 VRFSDLKS 234 Methanocaldococcus jannaschii
jgi:Ferp_2332   316 IEFSKFKS 323 Ferroglobus placidus DSM 10642
jgi:Ferp_1130   315 ERIENLEE 322 Ferroglobus placidus DSM 10642
WP_014807136    324 FNIQDMHv 331 Acetomicrobium mobile
CGB:Asulf_00884 316 IEFRKFGE 323 Archaeoglobus sulfaticallidus PM70-1
CGB:Asulf_00277 312 IEISEFKK 319 Archaeoglobus sulfaticallidus PM70-1
Q2FTS7          308 IPFSRVvd 315 Methanospirillum hungatei JF-1
WP_012616993    307 IQFSKVvg 314 Methanosphaerula palustris
WP_015286615    307 IRFSKIle 314 Methanoregula formicica
jgi:Mboo_0526   307 IPFSKVAD 314 Methanoregula boonei 6A8
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