1RQ8,1JO0


Conserved Protein Domain Family
CRS1_YhbY

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pfam01985: CRS1_YhbY 
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CRS1 / YhbY (CRM) domain
Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localizes to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.
Statistics
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PSSM-Id: 426547
Aligned: 486 rows
Threshold Bit Score: 56.6469
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RQ8_A          5 KQKRYLRSLAHNIDPIFQIGKGGINENMIKQIDDTLENRELIKVHVlqnnF---DD-KKELAETLSEATRSELVQVIGSM 80   Staphylococcu...
5_pfamImport    4 EETKEMRKRGLAVPALTKLAKNGYYGSLVPMVRDAFLSEELVRIDC----KglqKSdYKKIGCKLRDLVPCILVTFDKEQ 79  
41_pfamImport   4 EETKEMRNRGLNSPPIMRLTRNGVYVSVMEKVREAFKLQEVVRIDC----SgvdTSdCKKIGVKLRDMVPCVPLLFKNGQ 79  
10_pfamImport   4 EETKELRNRGLNSPPLTKLTRNGVYVNVVDKVREAFKTVEVVRLDC----ThvgTTdCKKIGVKLRDLVPCIPILFKDEQ 79  
33_pfamImport   4 EEATEMRKKGRQLPPICKLGKNGVYCKLVKQVREAFEACELVRINC----KdmnPHdCRKIGAKLRDLVPCVLLSFEYEH 79  
Q5VMQ5        306 DEAEDMRKRGRQLPPICKLGKNGVYLNLVKQVREAFEACDLVRVDC----SglnKSdCRKIGAKLKDLVPCTLLSFEFEH 381  Japanese rice
23_pfamImport   4 EKATEMRQKGRDLMPICKLGKNGVYWDLVTNIREAFEECELVRINC----QelnTSdYRRIGAKLKDLVPCALLSFENDH 79  
ERN15076      530 EEAKEMRKKGRKVPPICKLAKNGVYVDLVKNVKEAFEECELVRINC----QglnASdYKKIGAKLKDIVPCVLISFENEH 605  Amborella tri...
XP_002535109  373 EEASEMRRKGRKLIPICKLAKNGVYCNLVKEVREAFEECELVRIDC----QgvnGSdYRKVGAKLKELVPCLLISFEHEH 448  castor bean
Q9SL79        364 QEATNMRRKGRELMPICKLGKNGVYCDLVKNVKEAFEVCELVRIDC----QgmkGSdFRKIGAKLKDLVPCVLVSFENEQ 439  thale cress
1RQ8_A         81 IVIYR 85   Staphylococcus aureus
5_pfamImport   80 IVVWR 84  
41_pfamImport  80 IVLWR 84  
10_pfamImport  80 IILWR 84  
33_pfamImport  80 ILMWR 84  
Q5VMQ5        382 ILMWR 386  Japanese rice
23_pfamImport  80 ILMWR 84  
ERN15076      606 ILMWR 610  Amborella trichopoda
XP_002535109  449 ILMWR 453  castor bean
Q9SL79        440 ILIWR 444  thale cress
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