3CTA,2VBV


Conserved Protein Domain Family
CTP-dep_RFKase
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pfam01982: CTP-dep_RFKase 
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Domain of unknown function DUF120
This domain is a CTP-dependent riboflavin kinase (RFK), found in archaea, that catalyzes the phosphorylation of riboflavin to form flavin mononucleotide in riboflavin biosynthesis EC:2.7.1.26. Its structure resembles a RIFT barrel, structurally similar to but topologically distinct from bacterial and eukaryotic examples. The N-terminal is a winged helix-turn-helix DNA-binding domain, and the C-terminal half is most similar in sequence to a group of cradle-loop barrels. Archaeoglobus fulgidus RibK has this domain attached to pfam00325.
Links
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Statistics
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PSSM-Id: 426545
Aligned: 87 rows
Threshold Bit Score: 97.1707
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3CTA_A          101 VTSGMGEGRYYVARKQYIIQFQEKLGIIPYLGTLNIKVDQA-SLPELRKIRGFRGIHIEGFKTEDRTFGSVKAFPAKIQ- 178 Thermoplasma...
CCK79738          6 VIQGAHKAAFFTELDWVKLQCREKIGFVPFPGTLNLEL----SLSEVERLEKFSEGIWEELVPPDQNFCSSKVLPIWVG- 80  Desulfobacul...
Q67RN5           35 VVSGLGVAARWTTLDWFRAAIERLFGFKPVPGTLNA-IAEGdRQELDRLLLTAGTVLV----PPAEDICCSLVLPAHVAr 109 Symbiobacter...
jgi:Geob_0130     7 laDGLGRGAAFTKLDWVRCRLMDTVGIDPFPGTLNLTLDDDsNLARWRQWQDMPGHSLE---PPDTGFCRARCYPVQVMg 83  Geobacter da...
Q5P484           14 VCSGLGEGTRFTTIDWVVEEFRTRLGFAPCPGTFNLRMDGArWEALRLRLLATRGIAI----TPRHGLCAAKCFPVRLAg 89  Aromatoleum ...
BAL27021         14 VCPGRGEAAGFTSLEWVIVEFRKALGFIPWPGTFNLRMRGAsWDRARRRLRATAGIPI----APRAGFCAAKCFGVHIAg 89  Azoarcus sp....
WP_015232156     10 VFSGKNEGEFFVSL--YSKNIKNKLGFIPYPGTLNAKLISD-VEEFNQCLLKSKMIIIDPPNIPNTKFGRVYAYPILIFn 86  Caldisphaera...
CBRAS:ASAC_1027  28 VFSGLGEGEFFVNL--YAKNIRKALGFSPFPGTLNLKVEEPyVSALATALNRADPIMIDPPLVPGMRLGRVLAYPALLNy 105 Acidilobus s...
Q9YA27           10 VFSGLGHGSFYVSI--YARNLRRALGYTPYPGTLNLRVGDA-AERLAGCIERARGVRIEPPPIPGERLASVLAFPVEIEg 86  Aeropyrum pe...
Q971U9           12 VTAGLGEGRIFLSIPYYIESFKKYLGFEPYAGTLNIVIYDRiSLENRLILDLAKGIIIPEHKEPNRVLGSVKAFPSSIN- 90  Sulfurisphae...

3CTA_A          179 NI---PCFVIMPER--TVY-TDVIEIISDKYLREEINLHDGDRVSVEV 220 Thermoplasma acidophilum DSM 1728
CCK79738         81 NV---KGALILPDAdvKIHgRQVVEILAPVKLRDELGINDGDMVVLQl 125 Desulfobacula toluolica Tol2
Q67RN5          110 GVrshPVVLLRPMV--YGYnPAQVEFLAPVRLREALELRDGDEIVITI 155 Symbiobacterium thermophilum
jgi:Geob_0130    84 HI---PAAVLLPEV--ADYpRNKVELVAALPIRRHLALAPAAQLSVEl 126 Geobacter daltonii FRC-32
Q5P484           90 RL---SGALVLPDM--DDYpPDKLEVIAPLPVRHTLGLADGDAVQLHV 132 Aromatoleum aromaticum EbN1
BAL27021         90 HL---TGAVVFPAM--PDYpDDKFEIVAPLPIRETLGLQDGDLVNLSl 132 Azoarcus sp. KH32C
WP_015232156     87 SL---NSYILRPEI--TIYnKEVIEIISDKKLRDLLNINDGSIIEINI 129 Caldisphaera lagunensis
CBRAS:ASAC_1027 106 TI---KVFIVRPEI--TVYkNDVIELVAEIKLRDLLNLTDGSEVTVTI 148 Acidilobus saccharovorans 345-15
Q9YA27           87 GV---RGHIVRPEI--TVYkGDVVEIVADVYLRDVLKISDGDKVRFRl 129 Aeropyrum pernix K1
Q971U9           91 SIs--PAAIVIPAR--TTHpKSVIEIISPYYLREKLSLKDGDEVEIEV 134 Sulfurisphaera tokodaii str. 7
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