Conserved Protein Domain Family
MptE-like

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pfam01973: MptE-like 
6-hydroxymethylpterin diphosphokinase MptE-like
This domain can be found in a group of proteins, including archaeal 6-hydroxymethylpterin diphosphokinase (6-HMDPK), known as MptE, which catalyzes the formation of 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) from 6-HMD and ATP. 6-HMDP is the precursor of the pterin containing moiety of the essential C1-carriers tetrahydrofolate and tetrahydromethanopterin. This entry also includes a number of uncharacterized proteins from bacteria.
Statistics
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PSSM-Id: 426539
Aligned: 60 rows
Threshold Bit Score: 101.552
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8F6J8        202 RNTFVNTANFPD-SKNPRTRiESlKGkfldTPAMLVSAGPSLRSQCEWISKVRDKVFLFSCDTSFKALLKFGIVPDGVIT 280 Leptospira int...
Q7VHM3        284 KNTFINLGTNKAhLAYPILH----LPqrvnAPICVVGNGPSLDMLLPFIKANAHNMIIFSCGTALKPLKNAGIEPDFQIE 359 Helicobacter h...
Q31FM7        167 EAQLKNFPRNNFp-IQQIKN-RL-KG----QKAIMIAGGPSLDQSIEWIKDVQDSFFIFAVGRVSKKLYQAGVTPDFIIS 239 Hydrogenovibri...
WP_011713794  179 HAGLKNLAENRLr-AQQLHG-LF-KG----KTAVILAGGPSLLESLAHVKANRDKLVVIAVARIAGTLLKEQITPDFIFS 251 Magnetococcus ...
Q3A5G5        175 SRQLENLTENRIs-AAFLQN-LF-PG----KTAVLLAAGPSLDDLLPWVQQHRDKLVVLAVSRIARRLKEVDLAPDIFFS 247 Pelobacter car...
jgi:Sama_2337 173 KRQLENVADNLVp-AKVLSE-SF-SG----KSCIILAGGPSLDESLPWVINHQEELVIFAVSRICRQLCSIGLIPDIVVS 245
Q8EC71        173 QTQLENIADNQTp-AKILRN-TF-SG----KTCLVIAGGPSLDEHIDWIKHNNDNLFIIAVSRIAGKLADNGISVDIITC 245 Shewanella one...
Q12PQ5        175 KRQLENLSENLQp-AELLRN-TF-VG----KTSIILGGGPSLDDHIEWIKKNRNDLIIISASRVVGKLAKLGISSDIVIT 247 Shewanella den...
jgi:Gura_4091 174 FRQFENLAENRLhFSEYFLD-AF-EG----KTAIILAGGPSLKEALPWVKANRDRLVIIAVSRVCRQLIEAGVAPHIIIS 247
Q39YI4        174 LRQLENLAENRVaFSRTLVD-TF-KG----RTAVILAGGPSLREALPWVRENRDRLVLIAVSRISKILQSEQIVPHLVAT 247 Geobacter meta...
Q8F6J8        281 LDAqTHSFFH-FMGAESS-------NVPLFADLVSSPSILRSQKFTKIvHSLTAKYvvdasgefkREVTAGSKtaekllg 352 Leptospira int...
Q7VHM3        360 IER--------ISYLKDVlqsaplgKTTLLCGNMVQPDALALAEEAYI-FMRGGSA---------SAYFGGAKs------ 415 Helicobacter h...
Q31FM7        240 VDP-HELSYDnSKQMFYFs-----eESILLNCFHIAPRLLSQWSGISC-YFGEL-----------YPWEEASGns----- 296 Hydrogenovibri...
WP_011713794  252 IDP-HEVSFNnSHEMLHFw-----eKSFFVNLYHVTPMLLGQWRGRSA-YIGPL-----------FPWKNEIDgen---- 309 Magnetococcus ...
Q3A5G5        248 VDP-QQACFDvSKEMLHFg-----eRTLFVNSFHVVPQLISQWQGPAA-FIGKR-----------FPWP-ETStet---- 304 Pelobacter car...
jgi:Sama_2337 246 VDP-YEASFDvSKEMLTLp-----eSVLFINSNHIEPRLLANWRGPSV-YTGSY-----------LPWNSEETdan---- 303
Q8EC71        246 VDP-QDFSFDvSRDMFKLs-----hQTLLVNSYHVSHKILSQWNGPKA-YLGQR-----------YPWSGKHDhdn---- 303 Shewanella one...
Q12PQ5        248 VDP-QEHSFEvNEAMMALs-----qDILLVSAYHTCSDIVAQWNGNLL-YLGID-----------APWKCLEInsn---- 305 Shewanella den...
jgi:Gura_4091 248 VDP-HKVSFDvSKEMFHFa-----dEAVFLNFFHVTPLLLGQWQGRHL-FAGPF-----------LPWESALNkdn---- 305
Q39YI4        248 VDP-QKVSFEvSREMLYFadm--eeSPVLVSSYHASPLLVGQWGGRSA-YTDSL-----------FPWSTPLNiet---- 308 Geobacter meta...
Q8F6J8        353 pigDIQSGGSVATTAFDLLRNLGCKPIFLVGQDLAYSGR 391 Leptospira interrogans
Q7VHM3        416 --vVEFAAPYVGNAGFALA-CLLSEEVLICGLDCGYIKG 451 Helicobacter hepaticus
Q31FM7        297 ----tSPGPTVLHSAVVQAAYLGCDEIYLTGVDLCFY-N 330 Hydrogenovibrio crunogenus XCL-2
WP_011713794  310 -qlPSYPGITVSHQAIGCAIDMGFSQIILCGIDLCFSKE 347 Magnetococcus marinus
Q3A5G5        305 -flNA-PGPTVTNAAFATAMQMGFSQIILAGVDLCFSPE 341 Pelobacter carbinolicus DSM 2380
jgi:Sama_2337 304 ---isTVGPTVTNAAVKVAASMGFEQILLAGTDLCFSSS 339
Q8EC71        304 ---iiTVGPTVTNSSIRLAIEMGFTTLLLSGVDYCYSKS 339 Shewanella oneidensis
Q12PQ5        306 ---itTEGPTVTNCAVHLAAEMGFNQILLCGVDYCYSQT 341 Shewanella denitrificans OS217
jgi:Gura_4091 306 ---laYTGPTVGNTSISMAIHMGFSTIILAGVDLCHSRE 341
Q39YI4        309 ---hlYTGPTVSNYALSIAMNMGCETIVLAGVDLCFSRE 344 Geobacter metallireducens GS-15
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