Conserved Protein Domain Family
TctA

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pfam01970: TctA 
Tripartite tricarboxylate transporter TctA family
This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families. TctA is part of the tripartite TctABC system which, as characterized in S. typhimurium, is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules.
Statistics
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PSSM-Id: 426538
Aligned: 362 rows
Threshold Bit Score: 87.5046
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8TPE0            10 LFSVLAGYLLGIFSGLLPGIHTNNFALALVALAPflaekGV-AP-FYIALIILSNAVSHTFHDIIPSVFLGAP-DGDTA- 85  Methanosarc...
Q8EMU2             8 ILLALLGSIIFTLIGLISGSDET---AVLVPATLivvllGA-PP-EGVFAFFMAAVLSKHLTHAIPTALMGVPgDTTAT- 81  Oceanobacil...
jgi:Mvol_1104      8 LLSIFAGVICGICTGLCIGIHPNLFLPTVAFLTYe---yTLnDN--LLIYFLISWVISHYFINYIPTAYFGVPdSETAVs 82 
jgi:Aboo_0576     10 IAFVIIGALIGSALSMLPGLHVYNVIGFFLLFYFta-sfVL-DP-MLMVLMLIGMLVSYAFVFTIPSIYFSAP-DDSTM- 84 
Q5JDQ8            10 LIWSFAGVLFGSLISWIPGFHIYNIIALLVAVFgv---gEL-MPvQAFPFFAVGAIVAYAYVSAISSVYFSVA-DESAV- 83  Thermococcu...
jgi:Tagg_1356     11 LAWGLTGTLMGLMLSWIPGLHIFNLLVLVFALAPgf----itSNiYALPYFALGAVVGFSFASSIASTYLSVS-DESMM- 84 
NZAGRC:Abm4_0284   5 LIACFLGILIGSITGIFPGIHVNTSGAIVFTLSPyl-lqFT-SS-EVICVFLASLAISHAILEFIPSTLLGVP-DEGTA- 79 
agres:mru_0521     5 LAACFIGIAIGTGTGMVPGIHVNTAGAIMFASSGfl-lsFL-SP-EFLCIVMVSMSIAHALIEFVPSMLLGVP-EEGTA- 79 
jgi:Mfer_0579      1 mIACFIGVLCGVITGLIPGLHVNNVGALIFVFSAyf-lkNF-SP-EVLSVFLLSLSVSHALLEFIPSMLLGVP-KESTA- 75 
Q2NF62             5 LITLIFGIIIGTITGIMPGLHVNTVGIIIFSTSPtl-lsIT-NP-LVISTFLVSIALTHAMIEFIPSLLMGIP-SEDTV- 79  Methanospha...
Q8TPE0            86 LAVLPGHRLLLEGAGAEAVRLSALGSAGS-VVVSMLFVLPFSLFFG--AVYP-------------------YLQEYMAWV 143 Methanosarc...
Q8EMU2            82 PMLEHADFMRRIGLPHIALRKMISGGIIG-AFIALPVALLFAVFLSqfGEFF--------------------QENAGIIF 140 Oceanobacil...
jgi:Mvol_1104     83 VNILQKY--VKQGNAHNGI----FASGLG-GLLSVLLSTIIILSLFgvSVVInvisnntidvysvisviygGLKNYMAYI 155
jgi:Aboo_0576     85 FVLMPSLRYLKEGRGHEAVVLIATGALTG-LFAIVLVVPLFMGPLS--IVWD-------------------IVSTHLHWI 142
Q5JDQ8            84 FLLFPTQRYLLLGRGHEAVLLYLIGAVAGtLILVLGMLFVFPKVLP--PIYQ-------------------ATSPYITYF 142 Thermococcu...
jgi:Tagg_1356     85 LMLFPSQRYLLAGRGHRAVLLYLIGALTGaVFLAVFMATIGVYAMP--IIYN-------------------LFSPYYWFI 143
NZAGRC:Abm4_0284  80 LSILPGHRMVLEGRSKEAIRIVAIGGFGA-IIVTILTLPLFAIILP--GIHE-------------------VSKPYLWIF 137
agres:mru_0521    80 SSILPGHRMVLEGRSKEAIRIVSVGGFGA-IVVVILMLPIFAVALP--FLQD-------------------LSKPYTWMI 137
jgi:Mfer_0579     76 LVVHPAHKMILGGYGKKTIRLVAVGGLSS-ILILAFLFPLLSILLP--ILEK-------------------ILKPYICII 133
Q2NF62            80 LSVQPGHRMLFKGESMGAIRLVSFGGYCS-IVLLIIIMPILFIVLP--LIYY-------------------GLKEYIGIL 137 Methanospha...
Q8TPE0           144 LLTIVFIMLASEkgeevkg-----qgshakyRYKAYALLLFLITGVLGLFAFSRENvLLP------VISLGQASVLLPLL 212 Methanosarc...
Q8EMU2           141 TLAAVLIGYFSK-------------------GRWASIILIIPLALVIQGLNLi----STTiletslSISFFLGIAIGPML 197 Oceanobacil...
jgi:Mvol_1104    156 LSILLILAILSE-------------------KNRLWTIILSIISGLFGIYTLSINPsf--------------dITLTLVF 202
jgi:Aboo_0576    143 IGAVIAYMLLSEfpkdfgrhknplhglkegwKTIMAGYLTFFLSSILGIITFSKTIvPAN----------HAFQSLMAPL 212
Q5JDQ8           143 LVAIVLFMFMSEwpkegdrgktvkerlwlawRQILGGIFVFFLSGILGFIVTNTNIlPAT----------SAYTRLTPMF 212 Thermococcu...
jgi:Tagg_1356    144 LLAIVVFMFMSEypkeadygrtpreklwlawRQVLGGVLVFFASGILGFIASYSGLlRIE----------AAYARLTPLF 213
NZAGRC:Abm4_0284 138 LLVVSIILIYRLsh---------------nlKEMIWSFILFIFSGIIGWAIFETP--------------IPSSLSLMATF 188
agres:mru_0521   138 LTVVSILMIYKLsn---------------grLAFMWSILLFVLSGILGWIMLQTP--------------ISSGISLMCTF 188
jgi:Mfer_0579    134 LILASIYLLISLnr---------------svRSTLISTIIFLVSGIFGILVLKLP--------------FSSNVLLTTMF 184
Q2NF62           138 LIIIMILILYFSnk---------------snNKRLMSTLIFLVSGIMGLVLLNGN--------------LGSNIALLSML 188 Methanospha...
Q8TPE0           213 SGLFGAS---------------------------------QLIISLLTKSEIPAESvs-kfELSRKRilrG--------- 249 Methanosarc...
Q8EMU2           198 TDILLALsrsarpmitrhekneyklapekkswsgyfpnpfKVLTKKQTSAVA---------------------------- 249 Oceanobacil...
jgi:Mvol_1104    203 TGMFGIP---------------------------------ILIHNVlfg----------nfQNKDIS---Knlndiytpk 236
jgi:Aboo_0576    213 IGLFATS---------------------------------SIILNLISKYEIPEQNipksiDSTPKEllhG--------- 250
Q5JDQ8           213 IGFFGMS---------------------------------WVILNILSNPPMLPQKpedkvESSIYNtlkA--------- 250 Thermococcu...
jgi:Tagg_1356    214 IGFFGFP---------------------------------WVLRNIISKRSIPRQDtrdfvETSPGA------------- 247
NZAGRC:Abm4_0284 189 TGLFGIS---------------------------------TIIFSINDDSHIPHQNpf-veIELDRNslkN--------- 225
agres:mru_0521   189 SGLFGIS---------------------------------TILFSLNDSSSIPHQNky-ydFVIDKDtikS--------- 225
jgi:Mfer_0579    185 LGLFGVS---------------------------------TMLYSLKENSYIPYQSei-hnFKVNGNiirG--------- 221
Q2NF62           189 SGLFSVS---------------------------------NLIYSINNNSKIPHQKdi-knIVIDSKfkkS--------- 225 Methanospha...
Q8TPE0           250 --VFT-G-------STAGSFVA----WLPGVSSA-IAALLAGLFVRSdfdrrsvKKeSikPdsgEqkSflfsdpdadSq- 313 Methanosarc...
Q8EMU2           250 --G---T-------SFLSSLTF----ALSPVGMTaLMGELVGSRVKGq-------------------------------- 281 Oceanobacil...
jgi:Mvol_1104    237 mtFEKeSlfnyfyySLMGTIGGffriIIPAFGGSqINYFLGVFVRKI-------QNiQffQylqNllKinnnstnnnNnn 309
jgi:Aboo_0576    251 --AVA-G-------SSGGLFAA----FLPAVTAG-VGGYMASHGf----------------------------------- 280
Q5JDQ8           251 --SFG-G-------ALGGTIAA----VYPIITGG-MGAMVAGHMt----------------------------------- 280 Thermococcu...
jgi:Tagg_1356    248 --VIN-G-------SASGIIGGgiaaFFPIITGG-MGALVGGHMAS---------------------------------- 282
NZAGRC:Abm4_0284 226 --IIL-G-------GTTGGILG----FLPGFGPA-QGGIIAQDLtns--------------------------------- 257
agres:mru_0521   226 --IFA-G-------GTAGAILG----FLPGFGPA-QGSIIAQGV---------------------------------Cgt 257
jgi:Mfer_0579    222 --IIS-G-------TFASIFLA----FLPGFGPA-QGSVIAQEF---------------------------------Cgk 253
Q2NF62           226 --VFA-G-------SISGCIMG----LLPGLGPA-QGTLIAQII---------------------------------Tln 257 Methanospha...
Q8TPE0           314 ------aLeSSKEFIVSVS-GVNTSNAI--FGLV---------ALM--VIGKARSGAMAAVNEILgiGSP---------- 363 Methanosarc...
Q8EMU2           282 -------YkKSTTSLSTMNgVTESTYIA--ETII---------PLV--AFGIPLSPVAig------pAQAlfnappvftt 335 Oceanobacil...
jgi:Mvol_1104    310 tnnnnnnNnNNLKSLKNLE---NFLISQ--GAIVisnemlsiwALM--VIGVGRSGSAQLISNln-vDLElf-------- 373
jgi:Aboo_0576    281 ------aQkGDKSFLVSMG-ASRVVYYVgaIALF---------FLP--VLHLRRGALAMGINLFF--TPE---------- 330
Q5JDQ8           281 ------sQrGDDAFIISQG-VNRVLYYVgaFSLL---------FLP--NLRLTRGAGAWLVSSLY--TPK---------- 330 Thermococcu...
jgi:Tagg_1356    283 -------SrGDDAFLVSQG-AARTVYYT--GALF---------FLFhpTMRITRGSVAWLVGGVY--TPK---------- 331
NZAGRC:Abm4_0284 258 -----sdKdNTTSFLMIIS-GINTSDCL--FSLI---------SIY--LIGNPRSGIAVFISYII--NDF---------- 306
agres:mru_0521   258 sa----dgdDTKNFLLANS-GLNTSDTL--FSLI---------AIY--LIGNPRSGIAVYMSYLI--SEF---------- 307
jgi:Mfer_0579    254 n------knEYESLITAIS-SVNVSDSL--FSLL---------TVY--LIGNARSGIAVYISQFL--GEI---------- 301
Q2NF62           258 k---dikVdN---FLVTNS-GINVCDTL--FSLI---------AIY--LISNPRSAISVYVNNLI--EDI---------- 305 Methanospha...
Q8TPE0           364 -----------GFQVVLPFFAAILLTALFSYFSTVWIGHNAHH-LLr-----------------KLDYTKLCTGVLAGLA 414 Methanosarc...
Q8EMU2           336 epvnnlhtmmePFEFLIFGLIGIIIAAIIAYPFSMNFARKATVlVLk-----------------YINQEAIIGMFIGIVA 398 Oceanobacil...
jgi:Mvol_1104    374 -----------------kLLGVSLISAVLSFVLLLKISKIFSNlLLktqknesekqngnkisykKISKYLLF-GIVSIIT 435
jgi:Aboo_0576    331 -----------SVQQFYLVDMGIAIAGIYAFFVVIYASKFLAK-RIy-----------------KINPKVLNLIVLGIVV 381
Q5JDQ8           331 -----------SYSEYIAAIGVILLASGISFLFTYGLSRLIAR-SFn-----------------VMHIKKVSYFVAAVLV 381 Thermococcu...
jgi:Tagg_1356    332 -----------TWAEFYVGAAFIILAAALSFAVTLYLSKAVAW-LLt-----------------RVSYVYISVATLAFLV 382
NZAGRC:Abm4_0284 307 -----------TIFHLLLFIFTSLIAVSIGLSLALIIGDRFSK-FIe-----------------GINYGKISYISIGLMI 357
agres:mru_0521   308 -----------TLSHLMIFTFASLIAVSISLIICLKLGDGFSN-LMq-----------------GVDYRKLSISVILLMI 358
jgi:Mfer_0579    302 -----------DLMKILLFIFVGITSVSLSFFICIKIGEWMIE-NIa-----------------ELNYKLMTIFIVVIIT 352
Q2NF62           306 -----------TLIHILFFICVSLVCVSVTCVVSIKLGDLLIK-NIk-----------------KVDYNKLNIFIVVLIS 356 Methanospha...
Q8TPE0           415 ITVFLFTGf------FGLFIFVISTSIGMLPSFMKIRKSHAMG 451 Methanosarcina acetivorans
Q8EMU2           399 LLAFYEGGi------VGITVTFAMAMVGGILNRFlgvgvgvqf 435 Oceanobacillus iheyensis
jgi:Mvol_1104    436 ILTFLSQNm-----lYNIIIFAISIILGLLCLYKNVNTSILMS 473
jgi:Aboo_0576    382 MLVYFMTSw------QGLIIMSVATAIGLIPVLFNSRRSHCla 418
Q5JDQ8           382 VISYLLTGw------MGVVVLFVSTAIGLMAAAFNTRRSYCLG 418 Thermococcus kodakarensis KOD1
jgi:Tagg_1356    383 GLVFYLTGp------VGLALMLAAASVGFAAMVFNTRLSYCLG 419
NZAGRC:Abm4_0284 358 SIVYIFTFvyhgpvlYISLILITSTALGLLPHFQGLSKSHLMG 400
agres:mru_0521   359 VILYIFAIiyegpilYLTLALITSTAMGLLPHYLGVSKSHLMG 401
jgi:Mfer_0579    353 SFVYILSYfenanviLVSFCYFTSIFLGILPHSLKINKSYLMG 395
Q2NF62           357 MIVFFYTIlsqgciwYVILCYITSISLGILVNTLDLSKSNLMG 399 Methanosphaera stadtmanae DSM 3091
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