Conserved Protein Domain Family
ThiC_Rad_SAM
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pfam01964: ThiC_Rad_SAM 
Radical SAM ThiC family
ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis. Thic is a member of the radical SAM superfamily.
Links
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Statistics
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PSSM-Id: 426535
Aligned: 220 rows
Threshold Bit Score: 556.234
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012420871    105 TQRYYAQQGVITPEMEFVAIRENlgreqafkaiydrypnaksrpdeaaealetltmmprpseleaqegfgpssmvardrl 184 Akkermansia ...
A2SU66            2 TIVEDAKKGLITEEMKVVAKSEG--------------------------------------------------------- 24  Methanocorpu...
Q8TI28            2 TIVEDAKKGIITEEMKIVAKDEG--------------------------------------------------------- 24  Methanosarci...
Q0W1F1            2 sfLEQAKRGEITEEMKIVARDEG--------------------------------------------------------- 24  uncultured m...
WP_012609586      4 TQVQWAVEGRVTPVMEEIAAKEG--------------------------------------------------------- 26  Desulfatibac...
WP_013258838      3 sQVELAVQGKITPAIARIAAHEG--------------------------------------------------------- 25  Desulfarculu...
jgi:DaAHT2_1596   3 TQIQRARAGEISDEMAQVAAAEG--------------------------------------------------------- 25  Desulfurivib...
WP_012471694      3 TQIEYARAGVITPQMQQVAATEG--------------------------------------------------------- 25  Geobacter lo...
CCK82130          3 TQLEHARQGTITKQMQIIARTEG--------------------------------------------------------- 25  Desulfobacul...
C0QJ00            3 TQIELARDGIISRQMEQVAADEN--------------------------------------------------------- 25  Desulfobacte...

WP_012420871    185 dhqhaperrngcrmpayFTPEFVRDEIASGRALIPANINHPECePMAIGRNFLVKINANIGNSALGSSIEEEVEKLRWAI 264 Akkermansia ...
A2SU66           25 -----------------VTEDFIRRGIAGGHIVIPMTPYRKVK-LCGIGSGLRTKVNASIGTSSDIVNVEEELEKARQAE 86  Methanocorpu...
Q8TI28           25 -----------------LDPEFIRRGIAAGRIVIPTSPYRQVK-ICGLGEGLRTKVNASIGVSSDIVDVNMEVQKAIAAE 86  Methanosarci...
Q0W1F1           25 -----------------VTPEFVQRGVAAGRIVIPVTPYRNIR-PVGIGEGLRTKVNASIGTSSDIVDVDTEVRKAIAAE 86  uncultured m...
WP_012609586     27 -----------------VAASEIREHFAQGRIVCPQNANRpc-rNVGIGMGLSTKINASIGTSTDISNIDVEVAKAKAAQ 88  Desulfatibac...
WP_013258838     26 -----------------LDPEQVRQGFANGRIVAPIGSNHah-dAVGIGQGLRTKVNASIGTSTDIIDIDAEVKKAQAAQ 87  Desulfarculu...
jgi:DaAHT2_1596  26 -----------------VEAEMVRGGVAAGTIVIPCNHGRqq-rAVGIGRGLGTKVNASIGTSSDIIDYTAEEVKAKAAE 87  Desulfurivib...
WP_012471694     26 -----------------LAAELIRQRVAAGTIVIPWNHNRKPSrIAGIGQGLRTKVNASIGTSSDIIDYAAEVRKALAAQ 88  Geobacter lo...
CCK82130         26 -----------------LSESFILDHVAKGEIVIPCNPKRPGQkVTGIGTGLRTKVNASIGTSSDICDVNLEVAKAEAAQ 88  Desulfobacul...
C0QJ00           26 -----------------FNPEIIRTRVAAGEIVIPCNPNRTNQkVVGIGTGLRTKINASIGTSSDICSIENEVQKAIAIE 88  Desulfobacte...

WP_012420871    265 HWGADTVMDLSTGKNIHATREWILRNSPVPIGTVPIYQALEK---VGGKVADLSWEVFRDTLLEQARQGVDYVTVHAALL 341 Akkermansia ...
A2SU66           87 LAGADSLMELSTGGDFLDIRRRVCEQSNLSVGSVPLYQAFIEaarNKGGVVFMDEDDLFKITEQQAKLGTNFMAIHTGIN 166 Methanocorpu...
Q8TI28           87 KAGADTLMELGTGGDFLGIRKKVIDSISLSVGSVPLYQAFIEaarKYGSIVHMTEDELFNATEAQAKLGTNFMAIHTGIN 166 Methanosarci...
Q0W1F1           87 QAGADTLMELSTGGDFSEIRKKVCAATSLSVGSVPLYQAFIEaarKYGAVVHMKEDDLFRITEEQAKLGTNFMAIHTGIN 166 uncultured m...
WP_012609586     89 EAGADTLMELSVGGDLDKVRREVLAAVDLPVGNVPLYQAFCEaaeKYGDPNKLDSDMLFDIIEKQCADGISFMAVHCGIN 168 Desulfatibac...
WP_013258838     88 AAGADTLMELSVGGDLDKVRREVLAAVSLPVGNVPLYQAFAEaqrKYGDPNKLDEEMLFELIERQCADGIAFMAVHCGIN 167 Desulfarculu...
jgi:DaAHT2_1596  88 EEGADTLMELSVGGNLDEVRRRVLAATTLPVGNVPLYQAFCEasrRYGDPNKLDEELLFDLIEQQCADGISFMAIHCGIN 167 Desulfurivib...
WP_012471694     89 ESGADTLMELSVGGDLDRVRREVIAAVELPVGNVPLYQAFCDaarKYGDPNKLDPEELFDLIEQQCADGMAFMAVHCGIN 168 Geobacter lo...
CCK82130         89 EEGADTLMELSAAGDLDNVRQTVLANTDLAVGNVPLYQAFKEairKYKNPAKLDPEYLFDLIEKQLDDGLSFMAIHCGIN 168 Desulfobacul...
C0QJ00           89 EEGADTLMELSAGGNLDKVRQEVLKAVNLPVGNVPLYQAFKEtgrKYNDPSKLDPEFLFDLIERQLSDGLSFMAIHCGIN 168 Desulfobacte...

WP_012420871    342 LRFVNHTA---RRMTGIVSRGGSIMAQWSMIHEQENFLYSHWDEICSILAAYDIAVSIGDGLRPGSVADANDFAQLAELE 418 Akkermansia ...
A2SU66          167 YETVKRLKn-qGRHGGLVSRGGAFMTAWMLHNEMENPLYRRFDYLVEILKEHEVTLSFGNGMRAGACHDATDRAAIQELL 245 Methanocorpu...
Q8TI28          167 NITLDRLKa-hGRYGGLCSRGGAFMSSWMLHNEKENPLYANFDYLVEILKEHEVVLSTGNGMRAGAVHDATDRAQIQELI 245 Methanosarci...
Q0W1F1          167 RITVERLKk-qGRHGGLCSRGGAFMTAWMIHNDKENPLYSEFDYLLEILKKHEVTLSMGNGMRAGAVHDATDRAQIQELV 245 uncultured m...
WP_012609586    169 LYTIERLEkqgYRYGGLVSKGGASMVAWMKTNKRENPLYEEFDRVAAILKKYDVVLSLGNGLRAGAVADSFDRAMVQELL 248 Desulfatibac...
WP_013258838    168 LYTIERLErqnYRYGGLVSKGGAYMVAWMKANNRENPLYARFDRVVEILKKYDVVLSLGNGLRAGAIHDSFDRAMVQELL 247 Desulfarculu...
jgi:DaAHT2_1596 168 LYTIERLRkqgYRYGGLVSKGGTQMIAWMLANNRDNPLYTKFDRVVEILRRHDVVLSLGNGIRAGAIHDSSDRAQVAELV 247 Desulfurivib...
WP_012471694    169 RCTVERLQkqgYRYGGLVSKGGVSMVAWMLANNRENPLFEQFDRVAAILKKYDTVLSLGNGLRAGAIHDSSDRAQIQELV 248 Geobacter lo...
CCK82130        169 QYTIERLRkqgFRYGGLASKGGTYMVAWMDINKKENPLYEQFDRVCALMKKYDAVLSLGNGIRAGAIHDSHDRAQMAEMI 248 Desulfobacul...
C0QJ00          169 QYTIERLRkqgFRYGGLASKGGTFMVAWMDATGKENPLYEQFDRVCTLMKKYDAVLSLGNGIRAGAIHDSHDRAQMAEMI 248 Desulfobacte...

WP_012420871    419 VQGDLTMRAWKAGVQVMNEGPGHVPMHLIRENMSKQLEWCMEAPFYTLGPLVTDIAPGYDHITGAIGGAIIGQLGCAMLC 498 Akkermansia ...
A2SU66          246 INAELADQAHNAGVQCILEGPGHIPLDEIKTNVQLEKRVTNNKPFYMLGPLVTDIAPGYDDRVAAIGASVSSAAGADFIC 325 Methanocorpu...
Q8TI28          246 INSEVAEKAHQQGLQVIVEGPGHVPLDQIATNVKLMKEMSGHKPFYMLGPLVTDIAPGYDHIVTAIGASVSASYGCDFLC 325 Methanosarci...
Q0W1F1          246 MNSELSDQAYDFGVQVIVEGPGHVPLNEIEANVILMKRMSGNKPFYMLGPLVTDIAPGMDNIVAAIGASMSAAYGADFIC 325 uncultured m...
WP_012609586    249 INCELAELGRKMGCQMMVEGPGHVPMDEIEANIILQKRMSNNAPYYMLGPLPTDAGAGYDHVVAAIGASQSARYGADLIC 328 Desulfatibac...
WP_013258838    248 INCELAQLGREMGCQMLVEGPGHVPLDEIEANIILQKRMSDHAPYYMLGPIPCDVGAGLDHITAAIGAAQSARFGADLIC 327 Desulfarculu...
jgi:DaAHT2_1596 248 INCELAELGREMGCQMMVEGPGHVPLDEIEGNIQLQKRMSGDAPYYVLGPLPCDVGAGYDHVTAAVGAASSSRYGADLIC 327 Desulfurivib...
WP_012471694    249 FNCELAELGREMGCQMLVEGPGHVPLDEIEGNIKLQKRMSGDAPYYMLGPIPTDVAPGFDHITSAIGAAQSARYGADLIC 328 Geobacter lo...
CCK82130        249 INCELAEIGRNQGCQMMVEGPGHVPLDEIEGNIMLEKRMSGNAPYYVLGPIPCDTGAGYDHITAAIGAASSARFGADLIC 328 Desulfobacul...
C0QJ00          249 INCELAELGREQGCQMMVEGPGHVPLDEIQANIILEKRMSGNAPYYVLGPIPADTGAGYDHITSAIGAASSTWHGADLIC 328 Desulfobacte...

WP_012420871    499 YVTRKEHLGLPDREDVREGVVAYKLAAHAADLAKGHPSAQWRDNALAQARFEFRWEDQFNLSLDPQKARSFHDLTLPHan 578 Akkermansia ...
A2SU66          326 YVTPAEHLALPTPEEVYEGVMSSRIAAHVGDMVK-LPKTREADLEMGHARRDLDWERQYAVSINAEKARCIRNSRMPA-- 402 Methanocorpu...
Q8TI28          326 YVTPAEHLALPNLEDVITGVKTSRIAAHVGDMIKYPERARQWDLDMGRARRELDWEKMYSLAIDPEHARAVRNSRAPE-- 403 Methanosarci...
Q0W1F1          326 YVTPAEHLALPNVEDVKTGVMSARLAAHIGDMIKY--GKRDRDLEMAHARKNLDWNRMYELSLNPELAREIRSSRMPE-- 401 uncultured m...
WP_012609586    329 YITPAEHLALPNVDDVVEGVKVARLAVHIGDMGKLPEKTRMRDMDMSRARRDMDWEGQYANALFPEDARRIRDDRSPSc- 407 Desulfatibac...
WP_013258838    328 YITPAEHLALPNERDVIEGVKAARLAAYIGDTAKYPQKGRQRDMAMSKARRDSDWQKQYDLALFGDEAMAIRAERCPA-- 405 Desulfarculu...
jgi:DaAHT2_1596 328 YITPAEHLALPNEDDVREGVRVARLAVHMGDIVKLGERAKKRDRAMSRARRDMQWEQQFELGLFGRQAKEVRDSRSPG-- 405 Desulfurivib...
WP_012471694    329 YITPAEHLALPNEQDVREGVKAAKIAAYIGDMNKYPERMRERDKAMAKARRDLDWQKQFELALFPEDAKAIRASRIPE-- 406 Geobacter lo...
CCK82130        329 YITPAEHLALPDVNDVREGVRATRLAARIGDISKY-PDRRENEKQAAMARRDMRWNDLEKYLLFPEIARKTREERAPA-- 405 Desulfobacul...
C0QJ00          329 YITPAEHLALPTEADVREGVRATKLAVRIGDIAKY-PDRRENERLASMARRDMRWDDLEQHLLFPDIARKTRASRAPE-- 405 Desulfobacte...

WP_012420871    579 akKAHFCSMCGPDfCAMRLSQD 600 Akkermansia muciniphila
A2SU66          403 --DSDACTMCGDF-CAIKIVQK 421 Methanocorpusculum labreanum Z
Q8TI28          404 --DTDACTMCGNF-CALKIVNQ 422 Methanosarcina acetivorans C2A
Q0W1F1          402 --DKEACTMCGDY-CAVKIVQQ 420 uncultured methanogenic archaeon
WP_012609586    408 --DDKVCTMCGEF-CANRASGk 426 Desulfatibacillum aliphaticivorans
WP_013258838    406 --DEKVCTMCGEF-CANRggmk 424 Desulfarculus baarsii
jgi:DaAHT2_1596 406 --DQQTCTMCGEF-CAAKNAEA 424 Desulfurivibrio alkaliphilus AHT 2
WP_012471694    407 --DEATCTMCGNF-CASRGagk 425 Geobacter lovleyi
CCK82130        406 --QQETCTMCGDF-CAMKKGMe 424 Desulfobacula toluolica Tol2
C0QJ00          406 --DGGTCTMCGDF-CAMKKGNE 424 Desulfobacterium autotrophicum HRM2
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