2QH9


Conserved Protein Domain Family
DUF99

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pfam01949: DUF99 
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Protein of unknown function DUF99
This family includes uncharacterized archaebacterial proteins. Sequence and structure analysis to identify RNase H-like superfamily members, has clustered this family in endonuclease Clade V, thus suggesting endonuclease activity of these proteins.
Statistics
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PSSM-Id: 426526
Aligned: 91 rows
Threshold Bit Score: 146.473
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QH9_A           9 FLGIDDSF----DDRKCCVVGCVtCGGy-VEGFLYTEIDIDGLDATDKLISXVRRSkFREQIKCIFLPGITLGGFNLVDI 83  Archaeoglobus...
P61151           7 FIGIDDGYfvrnVHKKTKLIGAI-TKHtiLDGVLSREITIDGDDVSEKIIDMIKNSnHYYQIRGIILYGITFAGFNIADV 85  Nanoarchaeum ...
Q6LWU7           9 VIGIDDAPfn-kFDKEALIVGTYmRGNklVDEISFKKIEKDGFDSTEKILKIVKDk-HFTKINAIFLDGVTFGGFNIADI 86  Methanococcus...
Q58550          10 VIGFDDAPfn-kADKVCILIGTYmRGNriIDGIYFRKFKKDGMDVTEKIIDIVKEk-HYKKIKVIFLAGITFGGFNIADL 87  Methanocaldoc...
Q8TZ82          12 VLGIDDGYyg-peDDRALVVGVVmRGGqwIDGVMSTEVTVDGLDVTDRIAEMVNRSkHRPQLRVILTDGITFAGFNVLDI 90  Methanopyrus ...
Q0W5Y9          11 ILGIDDSPl---lSDRILVVGALlRGSgwVDGVLSTCVARDGTDAGERLAAMITGSkHYGQIRIVMLNGVTFGGFNVVDL 87  uncultured me...
BAI62018        12 ILGIDDSPl---lSKDILVVGAVmRGGdwLEGVVRTCITKDGLDATDKLAEMVTRSkHFGQIRVVMLNGVTMGGFNVVDM 88 
Q8TI87          13 VLGIDDSAl---lNEKVMIVGTVfRGGdwMDGVLRSEITRDGLDATEVISTMIKNSrHYAQLRIVMLDGVTYGGFNVVDI 89  Methanosarcin...
jgi:Mzhil_1814  13 ILGIDDSAl---iSDKIRIVGAFfRGGqwLDGVLSSMITRDGMDATDVIIDMVTSSkHYCQVRTIMLDGITYGGFNPIDI 89 
jgi:Metev_0127  19 VLGIDDSAl---lSDRIMIVGAVfRGGdwLDGVLRSEITRDGMDGTDTIIQMVKPSkHFVQLRVIMLDGITFGGFNPIDI 95 
2QH9_A          84 QRVYRETKIPVVVVXRRKPDxEEFDSAXR-NLENYelrRKIVEVAGEIHRIGD-----------IYIQTAGLTPSEAEKL 151 Archaeoglobus...
P61151          86 ELIYKNLGLPIIIVMERPPK-DIFYKAIEkYKPNG---IELIKKAGPIYKTKTpf-------gyTYYQVYGIDKDTASNI 154 Nanoarchaeum ...
Q6LWU7          87 VKIYNETKIPVIAVMEKEPDlLKMKSALKkYFFDFpekIEMLESFPKPEPFEN-----------IFIQCIGISFEDACKL 155 Methanococcus...
Q58550          88 WEINKETEKPVIVVIDKYPNkEKIFLALKkYFDDAderIKLINSFPEPEKMEN-----------IYVQYVGADKEFVKNV 156 Methanocaldoc...
Q8TZ82          91 KKLHEETGLPVISVIKRRPDvASVVSALS-NLDRTeerRKIVLRAGPVHSVKTrrd-----eppVYFQCAGVEPDVARVV 164 Methanopyrus ...
Q0W5Y9          88 KELHRATGLPVIAVMRHLPDmASIKAALD-NLPDPelrYQAILNAGPITEVQTpwr-----gqpVYIQCQGIETAAAAEL 161 uncultured me...
BAI62018        89 DVLSDKTGTPVISVMRRMPDmPSIRNALN-NLSEPdlrYGLILKAGKAVEVSTtrg------epVFIQYKGIDEASAVEI 161
Q8TI87          90 EELYRETGLPVIVVMRAYPDfEKIRAALR-HFSDGelrWEIIKKAGKIEKLVTekn-----gtpIYIQKAGIGLKSAEKI 163 Methanosarcin...
jgi:Mzhil_1814  90 VRVHRETDIPVIVVMRRCPDfDKIRLALT-HFDDGsqrFEIIKNGGKISRVHIsdyrianstspVYIQVSGISIEDASRI 168
jgi:Metev_0127  96 VKLNEETGLPVVAIMRKYPDfEKIESALK-YLPEPekrMDIIKKAGKIAEVTTyadq---rgspLYIQWSGLEEEDARRI 171
2QH9_A         152 VKASLIKGNXPEPVRISHLVASAII 176 Archaeoglobus fulgidus
P61151         155 INNLAIVSKIPEPARVAHMIARGVT 179 Nanoarchaeum equitans Kin4-M
Q6LWU7         156 IKKTRLRSKIPECLRISHLVGRGFL 180 Methanococcus maripaludis
Q58550         157 IKKTKLKSKIPECLRISHLIGRGFL 181 Methanocaldococcus jannaschii DSM 2661
Q8TZ82         165 LKRTATRHRLPEPIRVAHFIATGVT 189 Methanopyrus kandleri AV19
Q0W5Y9         162 VAATAIHSRLPEPLRLAHLIATGIV 186 uncultured methanogenic archaeon
BAI62018       162 VRSSSTHSRIPEPVRVAHLIATGIV 186
Q8TI87         164 VRLTSIRSNIPEPLRVAHLIATGII 188 Methanosarcina acetivorans C2A
jgi:Mzhil_1814 169 IQITCTRGNIPEPLRVAHLIATGIV 193
jgi:Metev_0127 172 VQQTSTRSNIPEPLRVAHLIATGIV 196
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