Conserved Protein Domain Family
CbiD
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pfam01888: CbiD 
CbiD
CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.
Links
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Statistics
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PSSM-Id: 426494
Aligned: 298 rows
Threshold Bit Score: 192.611
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013547773       254 LHSGLTTGTCAAAAAVAATWDIfntA----L-K---------------Kr----pS-EFSIVLPNgETIP---------V 299 Bacteroid...
CAK26951            54 LDSGYTLPVWVAVAAVAALRQL---RgdpsAeRi-----------------------GLELLQPA-GQRE---------L 97  Synechoco...
Q7V9B0               1 ----mTLPVWVAAAARAATEAL---LgrpfSaS---------------Q--------LLELPDRD-EPLA---------V 40  Prochloro...
Q46I27               1 -mnqFTLPVWVVAAAKSATNIL---IgnkfRdK---------------E--------RIDLPNNE-KSIS---------V 43  Prochloro...
jgi:Riv7116_3799    33 plpGYTLPVFAVAAAKAALINL----------QryldsyldnnlekiaEkls---siSLDLL--D-GSAE---------I 87  Rivularia...
Q7NK51               2 SRTGYTLPVFAAAAARAALLHL----------I---------------Ekvpc-asvQLDLL--G-EQAA---------I 43  Gloeobact...
jgi:Oscil6304_4689   2 AKTGYTLPVFAVAAAKAALMVL----------Spg------------sEapk---tvTLDLM--P-ELVE---------I 44  Oscillato...
jgi:Sta7437_0074     2 ARTGYTLPVFAVAAAKAALLHL----------Q---------------EkmnaepIvTLDLL--P-ESAE---------I 44  Stanieria...
jgi:Syn7502_01932    1 mKTGYTLPVFAIAAAKAAILRL----------Anp------------sEnle---avYLDLL--D-AGLDselnsrigkI 52  Synechoco...
Q2JI70               9 RPRGYTLPVFAVASARAALHHLlgiPlekeGgRl-----------------------VVAVQAEP-QSLEar-----ihI 59  Synechoco...

WP_013547773       300 P---VEPqRNtlhsniskngdsifeisATVIKDAGDDPDITNGMKVVANVAipfhpnaplppklpsqqrydITVCGGEGI 376 Bacteroid...
CAK26951            98 PieaVAPfADgs-------------alAISRCDPGPGMDLTRGLAVWVRARwaepl-----------egacFQLQAGVGV 153 Synechoco...
Q7V9B0              41 SvtsAAVlAGgeq------------alAISHCDPGSGLDLTRGLEIWVCVQwqelvdde----lnvhseawLNLLAGKGV 104 Prochloro...
Q46I27              44 PissSALlDNgkr------------slAVSHCQSGLPLDITRGVEIWAYIQlskggfqskg-kvrngfpdwLDFHAGYGV 110 Prochloro...
jgi:Riv7116_3799    88 PieqVAVlDSdt-------------alGITLSNPGDNLDLTRNTPIWALVKffprrn--------piqeqiLTLEAGEGL 146 Rivularia...
Q7NK51              44 PieqVARlDAet-------------alGVTRSDPGDNLDLTRHTPVWAWVHlevg------------tgevLRLEAGEGL 98  Gloeobact...
jgi:Oscil6304_4689  45 PiyqVAQlDGts-------------alGITRSDPGDNLDLTRNTPIWARVTwtpr------------qsqpLILEAGEGL 99  Oscillato...
jgi:Sta7437_0074    45 PieqVASlDSts-------------alAITLSDPGDNLDLTRNTPIWAWVRlsqr------------vseaLIVEAGEGL 99  Stanieria...
jgi:Syn7502_01932   53 AiaqSAPlDQnt-------------alGMTISDPGDNLDLTAGTPVWAWVQlyeise--------asanpeIILEAGEGL 111 Synechoco...
Q2JI70              60 PveqVAAlEKtt-------------alAITRSDPGPHLDLTRDTPVWAWVRleerd----------pedppLILEAGEGL 116 Synechoco...

WP_013547773       377 GIITMPGlgldlGAPAINATPRKMIEDNVKRYLKQmgipqhPNpIVITISVPGGEEIAKRTFNPRLGIIGGISIIGTSGI 456 Bacteroid...
CAK26951           154 GRLVEG------GEVCLSGFARDLLQHNLAALVPA------DRsVALEVVLPQGRERALRTSNAAFGVVEGLALIGTQAE 221 Synechoco...
Q7V9B0             105 GTLGSG------GEACVSRFARELLSRNLYPLVPS------GRgLQLEVVLPRGRDLAARTSNAAFGVVDGLALIGTQAD 172 Prochloro...
Q46I27             111 GKFQSS------GQPCISQFARDLLCINLYPLLPK------GSsIKVEIILPEGKDRASKTSNEAFGVVDGLSLIGTQAE 178 Prochloro...
jgi:Riv7116_3799   147 GK--TAT-----GEAAIYSFARRLFDANLLPLIPE------DKtLTVKIILPQGRELAKRTSNEAFGILEGLSLLGTSGI 213 Rivularia...
Q7NK51              99 GR--TAA-----GEAAIYRYARQLMEANVAPLVPT------GRtATVRFILPEGRALALRTSNAAFGILEGLALLGTSGL 165 Gloeobact...
jgi:Oscil6304_4689 100 GK--TET-----GEPAIYHYARQLFERNLFPLIPE------DQtLIVSIILPEGRQLASRTSNAAFGILEGLALLGTSGI 166 Oscillato...
jgi:Sta7437_0074   100 GK--TVT-----GKPAIYNYARRLFEANLLPLIPQ------DQtVTVSIILPFGRQLAQRTSNEAFGILEGLSLLGTSGI 166 Stanieria...
jgi:Syn7502_01932  112 GK--TIT-----GEPAIYKLAKTLAQINLLHLLPP------HTsARIKFILPEGRSLAKRTSNAAFGILEGLALLGTRAV 178 Synechoco...
Q2JI70             117 GRRTD-------GSPAIYAYARRLFEINLLPGIPP------DCrLRVRIILPEGKLLAERTSNAAFGVLEGLALLGTRAE 183 Synechoco...

WP_013547773       457 VKPFSSEAFVSSIHKSMEVACAA-N-SPHIVISSGAKSEKYIKAyYpDLPAQAFVHYGNFIGETLNIANELKLPQLTLGL 534 Bacteroid...
CAK26951           222 VQRSAAPDQLQGALDELRQRAERpQgCPELVLVVGENGLDLAPR-L-GLPVEVLLKSGNWIGPLLAAAAEQGVQRLLLFG 299 Synechoco...
Q7V9B0             173 VQVSASPDQLQQTIEQLRRQSAAsDfCGAMTLVIGENGLDLARQ-L-GLAAQPLLKIGNWLGPVIVAAAEAGVEQLLLLG 250 Prochloro...
Q46I27             179 VQISASPDQLKNTKELLHHKCSEaKfDGCLTFVIGENGMDLAMK-Y-GLPANQIIKTGNWLGPLLVAAAENGVKKLLLFG 256 Prochloro...
jgi:Riv7116_3799   214 SQPLSAAVHLEEFRDVLREKVKT---HRNLVFCIGANGYSVAES-L-SIPESTIVPTGNWLGALLVEAGLYKAESVLLLG 288 Rivularia...
Q7NK51             166 SQPLSAADHLESFRAALRERAER---ERRLVFCIGAGGLQAAGR-L-GLDQGATVQTGNWIGALLVEAGMLGIESVLLLG 240 Gloeobact...
jgi:Oscil6304_4689 167 SQPLSAADHLDEFRQILQGKVKN---SPHLTFCIGNNGLGVAQR-L-GIPESAIVQTGNWIGALLVEAGLRGAQSVLLLG 241 Oscillato...
jgi:Sta7437_0074   167 SQPLSAADHLEAFRLDLQNKVQN---HANLVFCLGSNGMHVAKQ-L-CIPEETIVQTGNWIGAMLVEAGLRGANSVLLLG 241 Stanieria...
jgi:Syn7502_01932  179 SQPLSVEDKLEEFRANLQVKARQ---NPDLVFYIGANGYQTAQN-M-GFSPDQLVQTANWIGVMLIEAALLNVNSITLVG 253 Synechoco...
Q2JI70             184 VEPSSSVESLEQARQELQQKLER---HKHLIFCVGSHGQQVALR-Q-GIPEDQILRVANWIGPLLVEAALRGAESIHLIG 258 Synechoco...

WP_013547773       535 MIGKAVKLAEG 545 Bacteroides helcogenes
CAK26951           300 YHGKLLKLAGG 310 Synechococcus sp. RCC307
Q7V9B0             251 YHGKLVKLAGG 261 Prochlorococcus marinus str. MIT 9313
Q46I27             257 YHGKLIKLSGG 267 Prochlorococcus marinus str. NATL2A
jgi:Riv7116_3799   289 YQGKLIKLAGG 299 Rivularia sp. PCC 7116
Q7NK51             241 YQGKLVKLAAG 251 Gloeobacter violaceus PCC 7421
jgi:Oscil6304_4689 242 YQGKLIKLAGG 252 Oscillatoria acuminata PCC 6304
jgi:Sta7437_0074   242 YQGKLIKLAGG 252 Stanieria cyanosphaera PCC 7437
jgi:Syn7502_01932  254 YHGKLLKLAGG 264 Synechococcus sp. PCC 7502
Q2JI70             259 YHGKLIKLAGG 269 Synechococcus sp. JA-2-3B'a(2-13)
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