2NWU,2WNY,2OGK


Conserved Protein Domain Family
RNA_binding

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pfam01877: RNA_binding 
Click on image for an interactive view with Cn3D
RNA binding
PH1010 is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteriztic homodimer structure in the crystal. dimerization of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family. Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner.
Statistics
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PSSM-Id: 426487
Aligned: 93 rows
Threshold Bit Score: 58.7083
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NWU_A                 7 XVVAEVRPSEDVNKVLSAISNFFDFEkxnTrk------eG-IIDILVLEART----LKSLLKFHRVLRNERIlds-arKY 74  Sacchar...
goetting:Ngar_c17760  12 EVNLVLHATEDGNKVLQSIHDVLSVPlerFsvspseghyKnKILLLKAILSSqe-aGELARRIMSLLNSSDR------EH 84 
ABK76743               8 EIDVIIHATEDESLVYEALEEQLGIIqemitiqnltghyDnPITMVNCRLDKkn-aEAFVDRLSRGMAPGEF------TR 80 
P58828                10 KVSAAVYPTEDPEKVTKAISVLFTGIelqKepld--aaeSeKRVSPAFRLTGeg-gLDLLFTLHGLIRREAIidsirnKV 86  Methano...
WP_013899276           5 EISAAVNPTENCSRIMDGIDNIFPQIemeLkksa-----------gayNIIGhg-kLNSLERMHDLLRKEKIldt-arKE 71  Methano...
jgi:Metev_1837       184 EVSAVVNPTENETYVANALKNIFGDIeleTldtaq---------qhkkRLSGtg-dVETLKNLHEMFRKEKIldt-grMQ 252
WP_015325742           5 RISARVNPTETEEKVRTAVQSIFPTVdliYn--------AtDDTGLYGNVEGis-dLGGLLHLHHLLREEEIidt-arTQ 74  Methano...
Q12U54                 5 RVSVIVNPTENEGKVASATGNMFPEIeleMherk-----------ygnFLEGeg-dINSLKNIHDLFRKERIidt-arTQ 71  Methano...
jgi:Vdis_2042          7 DLEVNIHATEDLDRAINYLTRLLTDKapivve-vlyghyGnPIYRVQSSIRDkdlaMSIIRSICSSLVNRDY-------- 77 
WP_012310019           7 EISTMLYPSEVEERVRSLLLSLCDCEireer---vsshyGySFKVLTCNLSGer-aEELLRKVICSLSDFEL------SS 76  Candida...
2NWU_A                75 LXKGIEG-----NTIAFXIHKQAAAVGVLSFVDSdKesplgAIKFYIE 117 Saccharolobus solfataricus P2
goetting:Ngar_c17760  85 LSSSLPEysdekGNLYLRLDKQRIVQGKVSLSEA-D-----AIRIRFR 126
ABK76743              81 LASAPQSsg-----vHIRLDKQRLVRGRLEDVEg-G-----SVRIRIH 117
P58828                87 FSKGLSSe---gLLVRFLLNKQAAFVGIPSVPAEeEpl--gSIEVVIR 129 Methanosarcina acetivorans C2A
WP_013899276          72 LEKGQSSd---gSYTCILINKQVATVGHINFPATeEpl--gSIHLTIK 114 Methanosalsum zhilinae
jgi:Metev_1837       253 LEGGLSId---gLSTHFIINKQVASVGRMNFPADeEpl--gSIHVTIT 295
WP_015325742          75 FEVGMSRd---aPFTSFRISKFVAFVGRLNFPAGeEpl--gSIHITMS 117 Methanomethylovorans hollandica
Q12U54                72 IQKNRWGe---pEKTFFMINKQVATIGRLNFPAKeEpl--gSIQIEIN 114 Methanococcoides burtonii DSM 6242
jgi:Vdis_2042         78 LLKTLGNrvdgsGNVFLRLDKQEFARGRIVISDGdD-----VIRIRFR 120
WP_012310019          77 LLDNIERyv-egRHLYIRLSKQDLALGRFKIYEGdPg---gYIRIKFS 120 Candidatus Korarchaeum cryptofilum
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