1WSC


Conserved Protein Domain Family
AMMECR1
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pfam01871: AMMECR1 
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AMMECR1
This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.
Links
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Statistics
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PSSM-Id: 426484
Aligned: 330 rows
Threshold Bit Score: 105.612
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WSC_B          22 KIARDSI-AnklgilkinledylsslndpILNK-------------K-GLAFVTLEtyygnST--SLRGCIGYVEa-VAP 83  Sulfurisphaer...
jgi:Nther_0238  12 YLAREGL-Khylryekyl---eppeemppLFYT-------------K-RGTFVSLK-----EKddNLRGCIGTLEatQNN 68  Natranaerobiu...
jgi:Ilyop_0486  10 QVALSSImEnfakeek------ilsipdeL-KV-------------K-AACFVTLH-----KIngELRGCIGTLEpfREN 63  Ilyobacter po...
WP_014015214   291 RLARESI-Ayylkhhslm--tvpkdlpedL-QD-------------K-AGAFVSLH------KgsRLRGCIGTFLpmQMN 346 Megasphaera e...
jgi:Adeg_0218  290 QVARRAI-Eaylnrgerl---evkdippeF-AR-------------R-AGVFVSLK------KegMLRGCIGTVGptQPN 344 Ammonifex deg...
jgi:Desca_0253 305 RVARQSL-Tsyleghwkd--pasydvpeeF-AR-------------G-AGAFVSLK------KngHLRGCIGTTAptRAN 360 Desulfotomacu...
WP_013840417   305 QVARESL-Tsylqgqwkt--sdrypvpeaF-SE-------------A-AGAFVSLK------KdgHLRGCIGTTGptRAN 360 Desulfotomacu...
jgi:Haur_2866   15 VLARQAV-Nrfirqgel----lpvteplpSDQR-------------RsQGVYVSLI------KagQLRGCVGSVQpqQAS 70  Herpetosiphon...
WP_012469296    34 EYARATMiS--------------------RLEKrpapsppaitignQ-RACFVTFfv------krQVMACFGSFTprHAT 86  Geobacter lov...
Q2JLD6          98 ALARQAI-Ayyfatgqvl---pppeeippHWRR-------------S-AGVFVTVS------TegRPRGCWGSLDpsGED 153 Synechococcus...

1WSC_B          84 LKEIVSKAAIAAAFSDPRFPPLSKGEFDNIIIEVTVLTKPQEIdvenrwelpKK---IKVGEDGLIVE-YGiLYSGLLLP 159 Sulfurisphaer...
jgi:Nther_0238  69 LAQEIIQNAVSAGVRDPRFPPVKLTELDDIKVSVDIISPLEKVsg------lDQ---LDPSKYGLVVE-KGy-RRGVLLP 137 Natranaerobiu...
jgi:Ilyop_0486  64 LYEEIWGNAKSAAYDDPRFPPLREYELEEIEISVDVLEKAEKIdk------iEK---LDPKIYGVIVS-SRg-RRGVLLP 132 Ilyobacter po...
WP_014015214   347 IASEIIHNAVSAATRDPRFYPVSLDELKDIDISVDVLGQPEAVas------pAD---LDPKKYGVIVM-SHa-QTGLLLP 415 Megasphaera e...
jgi:Adeg_0218  345 IVEEVIENAISAATRDPRFEPVDPQEIEDLTISVDVLEEPEPVes------lAE---LDPKEYGVIVV-SGs-RRGLLLP 413 Ammonifex deg...
jgi:Desca_0253 361 VVQEVAYNAVSAGTEDPRFYPVRLDELDELTISVDVLMPPEPIdg------vDQ---LDVKKYGVIVR-RGa-RSGLLLP 429 Desulfotomacu...
WP_013840417   361 VVEEVAYNAVSAGTRDPRFYPVRPDELDDLAISVDVLLPPEPIqs------vDQ---LDVKKYGVIVR-RDr-RSGLLLP 429 Desulfotomacu...
jgi:Haur_2866   71 LAKEVIYMAVAAAVHDPRFRPVQLDELDQLSYIVDLVENLALL---------KNkaaHDPVAEGLRVQ-RG-RNQGVVLP 139 Herpetosiphon...
WP_012469296    87 LFDEISDNIRLALKNDSRATRLTPELARSASIQITFPGQPQPI---------SDwrqVDPQHEGLLVEaSD-GRGVAIVP 156 Geobacter lov...
Q2JLD6         154 LARATIRAAVGAVTRDWRYVPLQPGELESASIQVAIVRRVVPIasag-rspfAAveqVDPTRMGLFVR-SG-TRGAVLLP 230 Synechococcus...

1WSC_B         160 QVPXEYCWDEETFLAETCIKAGLEPdcWlNNKVKIKKFQGIIF 202 Sulfurisphaera tokodaii
jgi:Nther_0238 138 DLeg--inTPKEQLAISAQKAGLSPs---DSNLTLYRFEVTRF 175 Natranaerobius thermophilus JW/NM-WN-LF
jgi:Ilyop_0486 133 DIeg--vdSPEKQVSIAREKGGILPg---E-NADIYRFQVKRY 169 Ilyobacter polytropus DSM 2926
WP_014015214   416 DLeg--vdTVQQQIAIAKEKAGIPPq---I-RPDLYRFTVTRY 452 Megasphaera elsdenii
jgi:Adeg_0218  414 DIeg--vdTPEQQLAIARRKAGIGPh---E-PVEIYRFRVTRY 450 Ammonifex degensii KC4
jgi:Desca_0253 430 DLeg--idTPEQQVAVAKQKAGIGPd---E-PVQLERFEVVRY 466 Desulfotomaculum nigrificans CO-1-SRB
WP_013840417   430 DLeg--vdTPEQQVDIARQKAGIGPh---E-KITLERFGVVRy 466 Desulfotomaculum ruminis
jgi:Haur_2866  140 NTtg--itTFEQQRQLAYQRAGLEl----TISATLERFQVRRI 176 Herpetosiphon aurantiacus DSM 785
WP_012469296   157 GEARTAQYAWRSALQ----RLGLN---ErSSGIRLYRFKAEYi 192 Geobacter lovleyi
Q2JLD6         231 GEALTTEW----QLATAKRLAGIPv----DQPVELFRVEAELL 265 Synechococcus sp. JA-2-3B'a(2-13)
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