Conserved Protein Domain Family
PvlArgDC

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pfam01862: PvlArgDC 
Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)
Methanococcus jannaschii contains homologs of most genes required for spermidine polyamine biosynthesis. Yet genomes from neither this organism nor any other euryarchaeon have orthologues of the pyridoxal 5'-phosphate- dependent ornithine or arginine decarboxylase genes, required to produce putrescine. Instead,these organisms have a new class of arginine decarboxylase (PvlArgDC) formed by the self-cleavage of a proenzyme into a 5-kDa subunit and a 12-kDa subunit that contains a reactive pyruvoyl group. Although this extremely thermostable enzyme has no significant sequence similarity to previously characterized proteins, conserved active site residues are similar to those of the pyruvoyl-dependent histidine decarboxylase enzyme, and its subunits form a similar (alpha-beta)(3) complex. homologs of PvlArgDC are found in several bacterial genomes, including those of Chlamydia spp., which have no agmatine ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine. In these intracellular pathogens, PvlArgDC may function analogously to pyruvoyl-dependent histidine decarboxylase; the cells are proposed to import arginine and export agmatine, increasing the pH and affecting the host cell's metabolism. Phylogenetic analysis of Pvl- ArgDC proteins suggests that this gene has been recruited from the euryarchaeal polyamine biosynthetic pathway to function as a degradative enzyme in bacteria.
Statistics
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PSSM-Id: 426480
Aligned: 88 rows
Threshold Bit Score: 99.9457
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESQ11790                 5 VPTKMFFTKGVGHHL-N-------KLQSFEMALREAGVEKCNLVAVSSIFPPDCR--IISKEAGIKHLVPGQITYVVMAK 74  Desul...
WP_005577699             1 -mstiRIVWGSASAP-T-------AMSSYDGALADAGIENYNIVSVSSVIPADAD--VEAVGTAPDLGPAGERLTVVEAR 69  Natro...
jgi:Halru_0088           1 -mstIRVVWGSSTGP-T-------EMAAYDGALADAGIENYNLVAVSSVIPAGVP--VEAVGTAPDLGPAGERLTVVEGR 69  Halov...
PRJNA71415:HALLA_17250   1 -mstiRIVWGTASAP-T-------AMASYDAALAEAGVENYNLVAVSSVIPADTT--VEAVGTAPDLGPAGDRLTVVEAR 69  Halos...
jcvi:BFO_2923            9 IPNTFFMAKGSGDSDlEk------HAGSYHMALFDAGIADFNIMTYSSVIPATAH--LVTMDEV-DLPPFGSELKTIMAV 79  Tanne...
Q7MVX1                   9 IPNTFFITKGSGESDlEl------HAGSYHMALFDAGISDFNIMTYSSVLPATAH--LATMDEI-DLPPFGSELKTIMAV 79  Porph...
OFO53508                 9 TPSAFFVTKGSGESDlEl------HAGSYHMALYDAGINDYNIMVYSSILPKTAH--LVTMDEI-DLPPFGSEMKTIMSV 79  Porph...
O84378                   7 YPTLAFHTGGVGESD-DgmppqpfETFCYDSALLQAKIENFNIVPYTSVLPKELFgnILPVDQCTKFFKHGAVLEVIMAG 85  Chlam...
jgi:Daes_2597           33 IPTAYFATTGTGQSD-QgippdpyETFSYDLALLEAGIENFNVVYYTSVLPPEAF--EVSLDTVKPHIHHGSVLETIMAK 109 Pseud...
WP_012237201            11 VPLAYFVTSGYGDTD-YgggldpwHTGSFDLALAMGGIENFNIVVCSSVIPPEAY--EIPIEVAKPHFRHGAVMEVILAS 87  Soran...
ESQ11790                75 ESTNEPGR--MVSTAIGLAR-PKD----SKQYGYISEHHAFGhTQRKAADFAEDLAATMLATTLGIdldldkaw-derkq 146 Desul...
WP_005577699            70 ATTAGPGS---VSAALAWSQsSPDdaesERGPGLFYEAAG-----EIAPEDVEQRVRDGIASGQEL-------------- 127 Natro...
jgi:Halru_0088          70 ARAAGPTS---VSAGLGWVEs------iDEGPGLFYEAAG-----EADPDDVERRVREGIDAGADL-------------- 121 Halov...
PRJNA71415:HALLA_17250  70 ATTAGPGR---VSAGLGWSQs------vEDGPGLFYEAAG-----ETDSDDIETRVREGIESGQDL-------------- 121 Halos...
jcvi:BFO_2923           80 SHGYQDE---FISAGLVYAWmYKDenfdEKAGGLVCEVSG--------RYRIEELEARLIRVINDLhqrty-------sk 141 Tanne...
Q7MVX1                  80 SHGYQDE---FVSAGVVYAWmYKDenfdEKAGGLVCEVSG--------RYRIEELESRLIRVINDLhqkty-------sq 141 Porph...
OFO53508                80 SHGTQDE---FVSAGIVYAWmYADenfdEKIGGLVCEVNG--------RYRIEELEARLTRVIIDLhekty-------sq 141 Porph...
O84378                  86 RGATVTDGtqAIATGVGICW-GKDkn-gELIRGWAAEYVE-FfPTWIDDEIAESHAKMWLK--KSLqheldlrsiskhse 160 Chlam...
jgi:Daes_2597          110 AGGVKGD---TVCAGVGRVW-AKDks-gKAIGGFAAEYERVYaGETVDKATVEADARKQLT--ASLnhelsirglvrdge 182 Pseud...
WP_012237201            88 VNGRAGE---TVTAGLGRVR-VRDrstgACLGGFAAEYEG---------HDDAATAASTLR--RELegialrrygaaqvd 152 Soran...
ESQ11790               147 vykIDHrRSFVSRSIAQTArghKDGLYTTVVALAVML 183 Desulfofustis sp. PB-SRB1
WP_005577699           128 ---RDWeFDETQVAVENGSa--DAGSYTTAIVVAVYg 159 Natronobacterium gregoryi
jgi:Halru_0088         122 ---REWdLGEASVHVEQARa--DSGAYAAAVVVAAYg 153 Halovivax ruber XH-70
PRJNA71415:HALLA_17250 122 ---RDWdFSEPRVRVESAQa--ASGTYTTAVVLAVYg 153 Halostagnicola larsenii XH-48
jcvi:BFO_2923          142 fylGDLnFVTEGMTIE--------RRYGTALAALCFT 170 Tannerella forsythia 92A2
Q7MVX1                 142 yylGELnFITEGITIE--------KRYGTALAGLCFM 170 Porphyromonas gingivalis
OFO53508               142 yylGELnFVTEGITIE--------KRYGTALVGLCFM 170 Porphyromonas sp. HMSC077F02
O84378                 161 fqyFHNyINIR-------------KKFGFCLTALGFL 184 Chlamydia trachomatis D/UW-3/CX
jgi:Daes_2597          183 mrfNITsLVIE-------------RKYGMALSALGFV 206 Pseudodesulfovibrio aespoeensis Aspo-2
WP_012237201           153 lefDEPaIASRQVQ----------NKHGTAIAALCwl 179 Sorangium cellulosum
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