Conserved Protein Domain Family
RB_B
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pfam01857: RB_B 
Retinoblastoma-associated protein B domain
The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.
Links
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Statistics
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PSSM-Id: 426478
Aligned: 77 rows
Threshold Bit Score: 116.487
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX76662       739 SLSLFFRKFYHLASVRLQDLCNRLELYEe---DLRKK--IWTCFEFSVMKHSDLMQDRHLDQILMCAVYVICKVT----- 808  common water...
EEH52586      1035 SLRIFFAKVMRLSARRLADLCDRLSLPS----SLTQQ--AYSLVEHALYDNTSLLYNRHLDQIILCAVYGTCKVNkdgal 1108 Micromonas p...
XP_001421627   745 ALRMFFAKVMHLAARRLGDLASRLNLST----DVTRD--IYALIEHVVYEQTNLVYNRHIDQIILVSVYGVCKASag--i 816  Ostreococcus...
EDP08606       814 llfeFLRKVLKLTSFRLALLCENFDFSPlegpEVNSK--VYEAIEHALYKQTHLFYNRHIDQIMLSTLYGYCKVHk---- 887  Chlamydomona...
XP_002954473   774 fcckvrKQVLKLAAFRLAVLCDNFDFSPlqrlDVNTKvwVYQTIEHALFFQTHLFYNRHIDQIILSALYGFCKVHr---- 849  Volvox carte...
CAP24856       737 TLRIFLKRTYFTAARRLQELTDRIAMAT----RPKSQ--CWSVFDYLLRNDTLIFMDRHLDQIILCCVFVIMRMH----- 805  Caenorhabdit...
EGT35439       665 TLRIFLKRVYFTAASRLQELTDRIGMGS----RGKSQ--CWSLFDYLLRSDTLIFMDRHIDHILLCCVFVIMKIN----- 733  Caenorhabdit...
10_pfamImport    1 TLRIFLKRTLFTGARRMQELTDRVSMGV----RAKSQ--CWSLFDYLLRNEPLIFMDRHLDQIILCAVYVILKIN----- 69  
G5EDT1         744 TLRIFLKRTYFTAARRLQDLTDRVSMGA----RAKSQ--CWSLFDYLLRNDTLIFMDRHLDQILLCCVFVIMKIN----- 812  Caenorhabdit...
XP_003111277   718 rvscacRRTYFTAARRLQELTDRVSMGT----RGKSQ--CWSLFDYLLRNDTLVFMDRHIDQIILCCVFVILRIN----- 786  Caenorhabdit...

EFX76662       809 -GRDKNFTDIMRCYRTQPHASSHVYRSVLLCTKARRGSASEEDdeaatgstvkvngdekkaetngekalppvrssstlpf 887  common water...
EEH52586      1109 kGKTVPFRDIIYHYQKQPQCREEVFWTVVMSQSDPELE------------------------------------------ 1146 Micromonas p...
XP_001421627   817 sSNSLQFKDIIYQYSKQPQSSEEIFWAVVLEQNDPELE------------------------------------------ 854  Ostreococcus...
EDP08606       888 -LSQVSFREIIAQYRKQPQAQQSIFRSVVIDQVLPTLQ------------------------------------------ 924  Chlamydomona...
XP_002954473   850 -LAQVSFREIIAHYRKQPQAQPSIFRSVVVEQSNPSLQVG-Q-------------------------------------- 889  Volvox carte...
CAP24856       806 -GSSITFHEIMGQYRRQSSSAMYVYRNVSVFRDQVDEDNPVPVnlketis------------------------------ 854  Caenorhabdit...
EGT35439       734 -ESPVTFQEILGQYRRQNSDASSVYRNVSVFYDQLDEENGEPIniketit------------------------------ 782  Caenorhabdit...
10_pfamImport   70 -VSGTTFLDLMAHYRRQAKDAVFVYRNVTIFSEQLEENGKVSVntketvm------------------------------ 118 
G5EDT1         813 -ESSMLFTEIMAQYRRQSANSLLVYRSVTVFQEQLNPENPQAVntketil------------------------------ 861  Caenorhabdit...
XP_003111277   787 -ESPITFTEILAQYRRQSTQAMQIYRHVPVFAQLLDGSNPSDLntketil------------------------------ 835  Caenorhabdit...

EFX76662       888 pqpsscpptptglagtsssfEYEDRGDLILFYNTVYVRRLQ 928  common water flea
EEH52586      1147 ---------------------VITQGDIIAFYNKVFVPAVK 1166 Micromonas pusilla CCMP1545
XP_001421627   855 ---------------------VVNRGDIISFYNKVFVGRVK 874  Ostreococcus lucimarinus CCE9901
EDP08606       925 ---------------------IQSRADIIGFYNAVFVPAMR 944  Chlamydomonas reinhardtii
XP_002954473   890 ---------------------VGRRADIIAFYNQVFVPCMK 909  Volvox carteri f. nagariensis
CAP24856       855 -------------erleappKSKTTVDVIKYYNIEFLERIK 882  Caenorhabditis briggsae
EGT35439       783 -------------erleaptRIKTEVDVIKYYNLEFRERIK 810  Caenorhabditis brenneri
10_pfamImport  119 -------------erlegpqKEKETVNLIRYYNLEFRDRIK 146 
G5EDT1         862 -------------erlegpqKEKTTVDIIKYYNIEFRDRIK 889  Caenorhabditis elegans
XP_003111277   836 -------------erleaprKFTCKVDIIKFYNIEFRDRIK 863  Caenorhabditis remanei
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