1JNP


Conserved Protein Domain Family
TCL1_MTCP1
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pfam01840: TCL1_MTCP1 
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TCL1/MTCP1 family
Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.
Links
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Statistics
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PSSM-Id: 426467
Aligned: 17 rows
Threshold Bit Score: 133.65
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1JNP_B         1 MATQRAhrAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEK--------FQ--VILRQEDVTLG-EAMSPSQLVPYE 69  house mouse
6_pfamImport   1 MAELPSn-IHLTSHPTYLSIRGPLLYEDEKQHTWLNLVMDTEGV--------LQ--VRFLQVDIPSGhIPLTTSSLTSST 69 
XP_009247734   1 MAECPIlgEAVTDHPDRLWAWEKFVYLDEKQRAWLPLTIEIKDR--------LQlrVLLRQEDVVLG-SPMTPTQIGPSL 71  Sumatran orangutan
ERE84588       1 MAEEPVyrPETPQDPQRLWIWERHVYLDENKRSWLPIVLKTDEK--------FQ--VILCQQDVPLG-LAMIPEQLETYE 69  Chinese hamster
EDL81818       1 MANQLAyrPETPPHPDRLWLWEKHVYLDEFRRSWLPIVIKSNGK--------FQ--VIMRQKDVILG-DSMTPSQLVPYE 69  Norway rat
XP_002696811   1 MAEGAFfgAHTPLHPDHLWIWEKAVYVDENQRTWLPITIEIEGS--------LQ--VLMRQEDVPLG-DPVSPSQLGPYL 69  cattle
P56844         1 MADSVRf-PCMPFPPCFLVCTRDDIYEDEHGRQWVAAKVETSSHspycskieTCvtVHLWQMTTLFQ-EPSPDSLKTFNF 78  house mouse
P56842         1 MADSVHf-PWMPFPPRFLVCTRDDIYEDENGRQWVVAKVETSRSpygs-rieTCitVHLQHMTTIPQ-EPTPQQPINNNS 77  house mouse
P56845         1 MAAVSVd-PQRPL-PVLLVSVSLGIYEDEHHRVWIAVNVETSHSshgn-rieTCvtVHLQHMTTLPQ-EPTPQQPINNNS 76  house mouse
P56840         1 MAAAAFd-PLGPL-PVYLVSVRLGIYEDEHHRVWIVANVETSHSshgn-rrrTHvtVHLWKL--IPQ-QVIPFNPLNYDF 74  house mouse

1JNP_B        70 LPLMWQLYPKDRYRSADSMYWQILYHIKFRDVEDMLLELID 110 house mouse
6_pfamImport  70 IPLLWTLYPGNQYLDSKCRYWRIVHHVKENGVEEMILELME 110
XP_009247734  72 LPVMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLP 112 Sumatran orangutan
ERE84588      70 LPLIWQLYPGKKYQGSDSMLWQILYQIKFSGVKDMLLELME 110 Chinese hamster
EDL81818      70 LPLMWQLYPEERYRSSNSEFWQIVYHIKFKDDEDMLLELLD 110 Norway rat
XP_002696811  70 LPVMWQLYPGRRYRASDSSFWRIVYHIEIGGTEDMLLEQMP 110 cattle
P56844        79 LPRTWRLESRNTYRGADAMHWRLVNHSQFYGTEELVLMLDS 119 house mouse
P56842        78 LPTMWRLESMNTYTGTDGTYWRLLDHSQMGDTLQLILDIVI 118 house mouse
P56845        77 LPTMWRLESRNTYTGTDGTYWRLLDHSQMGDTVQLTLDIII 117 house mouse
P56840        75 LPTTWKLESRNIYWATDGTHWRLLDHSQLGDTEQLILMLVl 115 house mouse
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