3TQT


Conserved Protein Domain Family
Dala_Dala_lig_N

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pfam01820: Dala_Dala_lig_N 
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D-ala D-ala ligase N-terminus
This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.
Statistics
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PSSM-Id: 426454
Aligned: 509 rows
Threshold Bit Score: 61.4656
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TQT_A          6 HISVLCGGQSTEHEISIQSAKNIVNTLda-akYLISVIFIDHvgrwyliDQPEMFLAHSPDHLVkegsarpi-------- 76   Coxiella burn...
XP_009416313  505 KVFVLFGGETSERQVSLMSGTNVWLNLqgygdLDVIPCLLAP-------ANGYGSAELKNADQQeicrtvwtlpyslvlr 577  wild Malaysia...
XP_006658994  426 KVFVIFGGDTSERQVSLMSGTNVWLNLqgfddLDVIPCLLTP-------GDEYSSHDQNINENSrdvwilpyslvlrhtt 498  malo sina
XP_006843685  497 KVFVIFGGETSERQVSLMSGTNVWLNLqnfddLEVTPCLLAP-------ANGYLSQGSEEKGNLtrtvwslpysvvlrht 569  Amborella tri...
EEF28594      499 KVFVLFGGDTSERQVSLMSGTNVWLKLqafddLDVTPCLLAP-------SNGQSSDDSFRAVWLlpyslvlrhtteevld 571  castor bean
NP_001326477  486 KVFVIFGGDTSERQVSVMSGTNVWVNLqryvdLNVTPCLLSP-------SLSNSLGASSNLDNRevwvlpysvvlrhtae 558  thale cress
XP_009135089  371 KVFVIFGGDTSERQVSVMSGTNVWMNLqrfadLKVTPCLLSP-------SLSNSSGAFPDKTESdldnrevwllpysvvl 443  field mustard
KRH00379      495 KVFVIFGGNTSERQVSLMSGTNVWLNLlafhdLEVTPCLLSP-------TSECASSVDIGKKADdvmnrtvlslpyslvl 567  soybean
XP_019077428  492 KVFVIFGGDTSERQVSLMSGTNVWLNLqafndLEVIPCLLAP-------TSGYSSKTDMDEKELdvrmktiwtlpyslvl 564  wine grape
XP_013749045  485 KVFVLFGGDTSERQVSVISGTNIWMNLqrfgdLKVTPCLLSS-------SLSNSMGPFPDKTESdldnrevwllpysvvl 557  rape
3TQT_A         77 ------------------------------------tiafgdaAKPWQSLNGDGRRYSAD-----------CVFPMVHGT 109  Coxiella burn...
XP_009416313  578 htteevlaaciea-vepdralltshlrdnvmselsaalskhywFSGFDINEELPANFTLEnwikhakesqsIVFIAVHGG 656  wild Malaysia...
XP_006658994  499 eevhaacieaie----permevtsrlrdqvmnelgqalskhdwFVGFDIANKQPIKYSLQqwinhvkeakaVVFIAVHGG 574  malo sina
XP_006843685  570 teevlaacmeai---epvraaltskyrdevmvellegltkhkwFSGFDISDAPPKRYVLEewiaqakevqaTVFIALHGG 646  Amborella tri...
EEF28594      572 acieaiepa---------qaaftshlrsqvtndlmeglkkhswFKGFDIADELPTIFSMKewiklakeiqaTVFIAVHGG 642  castor bean
NP_001326477  559 evlaacleave-----pvralftsllqkqvmedlmdgfknqswFAGFDITDELPRKYSLKewikhakeaqaTVFIAVHGG 633  thale cress
XP_009135089  444 rhtaeeilaecleaiepdralftsmlqkqvmedlmdglknqswFGGFDITDELPMKFSLRewiklakeaqaTVFIAVHGG 523  field mustard
KRH00379      568 rhtteevldacmeaieperaaitsdlrkkvmndlmeglkdhnwFTGFDIADDLPAKFSLRqwiklakevqaTIFIAVHGG 647  soybean
XP_019077428  565 rhtteevlaacieaiepdraaltselrnqvmndlmeglkkqhwFTGFDLADEPPVRYSVEqwvklakevqaTVFIAVHGG 644  wine grape
XP_013749045  558 rhtveevlaacmeaidpdrarftsllqqqvkeeimdalknqswFAGFDITDEVPMRFSLKdwvklakeseaIVFLSAHGG 637  rape
3TQT_A        110 QGEDGALQGLLELLNLPYVGA 130  Coxiella burnetii RSA 493
XP_009416313  657 IGEDGTLQSLLEAAGVPYTGP 677  wild Malaysian banana
XP_006658994  575 IGEDGTIQSLLESAGVPYTGP 595  malo sina
XP_006843685  647 IGEDGTLQSLLEASGVPYTGP 667  Amborella trichopoda
EEF28594      643 IGEDGTLQSMLEAQGVPYTGP 663  castor bean
NP_001326477  634 IGEDGTLQGLLEDEGVSYTGP 654  thale cress
XP_009135089  524 IGEDGTLQALLDDEGVAYTGP 544  field mustard
KRH00379      648 IGEDGTLQSLLDAEGVPYTGP 668  soybean
XP_019077428  645 MGEDGTLQFLLEAGGVPYTGP 665  wine grape
XP_013749045  638 IGEDGTMQALLEDEEVPYTGS 658  rape
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